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Journals / Türk Doğa ve Fen Dergisi / 2026 / Cilt: 14 Sayı: 1

The Potential Prognostic Value of Glutatione-S Transferase Izoenzymes in Non-small Cell Lung Cancer

Aydın Keskin(KIRIKKALE UNIVERSITY)0000-0003-2360-7692
Pınar Kaygın(KIRIKKALE UNIVERSITY)0000-0003-0127-1753
Kayhan Başak(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER)0000-0003-1960-8924
Fatma Çakmak Kazanci(Çerkezköy State Hospital)0000-0001-5064-0952
Sezen Yılmaz Sarıaltın(ANKARA UNIVERSITY, FACULTY OF PHARMACY)0000-0002-8387-4146
Onur Dirican(ISTANBUL GELISIM UNIVERSITY)0000-0003-0511-6611
Abbas Ali Husseini(ISTANBUL GELISIM UNIVERSITY)0000-0002-8861-7106
Muharrem Atlı(KIRIKKALE UNIVERSITY)0000-0002-2453-1370
Can Yılmaz(VAN YUZUNCU YIL UNIVERSITY)0000-0002-0028-6614
Serpil Oğuztüzün(KIRIKKALE UNIVERSITY)0000-0002-5892-3735
Pages
48–57
Publication Date
2025-03-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Çalışma, KHDAK'de GST izozimlerinin prognostik değerini desteklemektedir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:GST izozimlerinin prognostik değerini değerlendirmek için GST izozim düzeyleri ile tümör belirteçleri arasındaki korelasyonları araştırmak.
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Key Findings & Data:Bu retrospektif çalışmada adenokarsinom ve skuamöz hücreli karsinomu olan 40 hastanın klinik verileri analiz edilmiştir.
💡
Conclusion & Impact:Çalışma, KHDAK'de GST izozimlerinin prognostik değerini desteklemektedir.
🔬Design:Araştırma Makalesi
📍Scope:40 hasta
⚙️Variables:Lung cancer · Glutatione-S Transferase · Caspase-3

Abstract

GST izozimlerinin prognostik değerini değerlendirmek için GST izozim düzeyleri ile tümör belirteçleri arasındaki korelasyonları araştırmak. Bu retrospektif çalışmada adenokarsinom ve skuamöz hücreli karsinomu olan 40 hastanın klinik verileri analiz edilmiştir. Tümör ve komşu sağlıklı doku örnekleri, GST enzimlerinin (Sigma, Omega, Pi, Mu) ve kaspaz-3, Bcl-2, p38, p53'ün profilini çıkarmak için immünohistokimyasal olarak boyandı. Protein ekspresyon düzeyleri ile hasta özellikleri arasındaki ilişkiler incelenmiş ve GST enzimleri ile Kaspaz-3, Bcl-2, p38, p53 arasındaki korelasyonlar analiz edilmiştir. Tüm belirteçler için tümörlü ve sağlıklı dokular arasında anlamlı immünohistokimyasal farklılıklar bulunmuştur. GST enzimleri (GSTS, GSTO, GSTP, GSTM) ağırlıklı olarak tümörlü dokularda eksprese edilmiş, GSTO ve GSTP yüksek ekspresyon seviyeleri göstermiştir. SCC dokularıyla karşılaştırıldığında, GSTP ekspresyonu AC dokularında yaklaşık %30 daha yüksektir. Buna karşılık, GSTO ekspresyonu ikinci evre tümörlerde, özellikle de AC dokularında yaklaşık %25 oranında artmaktadır. Korelasyon analizi, tümör dokularında Bcl-2 ile kaspaz-3, p38, GSTS arasında, kaspaz-3 ile GSTP arasında ve p38 ile GSTM arasında anlamlı pozitif ilişkiler olduğunu ortaya koymuştur. Çalışma, KHDAK'de GST izozimlerinin prognostik değerini desteklemektedir.

Özet

GST izozimlerinin prognostik değerini değerlendirmek için GST izozim düzeyleri ile tümör belirteçleri arasındaki korelasyonları araştırmak. Bu retrospektif çalışmada adenokarsinom ve skuamöz hücreli karsinomu olan 40 hastanın klinik verileri analiz edilmiştir. Tümör ve komşu sağlıklı doku örnekleri, GST enzimlerinin (Sigma, Omega, Pi, Mu) ve kaspaz-3, Bcl-2, p38, p53'ün profilini çıkarmak için immünohistokimyasal olarak boyandı. Protein ekspresyon düzeyleri ile hasta özellikleri arasındaki ilişkiler incelenmiş ve GST enzimleri ile Kaspaz-3, Bcl-2, p38, p53 arasındaki korelasyonlar analiz edilmiştir. Tüm belirteçler için tümörlü ve sağlıklı dokular arasında anlamlı immünohistokimyasal farklılıklar bulunmuştur. GST enzimleri (GSTS, GSTO, GSTP, GSTM) ağırlıklı olarak tümörlü dokularda eksprese edilmiş, GSTO ve GSTP yüksek ekspresyon seviyeleri göstermiştir. SCC dokularıyla karşılaştırıldığında, GSTP ekspresyonu AC dokularında yaklaşık %30 daha yüksektir. Buna karşılık, GSTO ekspresyonu ikinci evre tümörlerde, özellikle de AC dokularında yaklaşık %25 oranında artmaktadır. Korelasyon analizi, tümör dokularında Bcl-2 ile kaspaz-3, p38, GSTS arasında, kaspaz-3 ile GSTP arasında ve p38 ile GSTM arasında anlamlı pozitif ilişkiler olduğunu ortaya koymuştur. Çalışma, KHDAK'de GST izozimlerinin prognostik değerini desteklemektedir.

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Cite This Article

Keskin, A., Kaygın, P., Başak, K., Kazanci, F. Ç., Sarıaltın, S. Y., Dirican, O., Husseini, A. A., Atlı, M., Yılmaz, C., Oğuztüzün, S. (2025). The Potential Prognostic Value of Glutatione-S Transferase Izoenzymes in Non-small Cell Lung Cancer. Türk Doğa ve Fen Dergisi, Cilt: 14 Sayı: 1, 48–57. https://doi.org/10.46810/tdfd.1585199

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