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Journals / Türk Doğa ve Fen Dergisi / 2025 / Cilt: 14 Sayı: 4

Investigation of Toxicity and Pharmacokinetic Profiles of Some Frequently Used Drugs in the Emergency Departments

Acil Servislerde Sık Kullanılan Bazı İlaçların Toksisite ve Farmakokinetik Profillerinin Araştırılması

Serhat Karaman(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0003-4554-1364
Pages
203–208
Publication Date
2025-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Finally, the highest LD50 values are obtained for Captopril (2078 mg/kg) and Pheniramine maleate (343 mg/kg).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this paper, pharmacokinetic profiles and toxicity values, also known as ADME parameters, for some drugs frequently used in hospital emergency services, such as Thiocolchicoside, Pheniramine maleate, Captopril, Dexketoprofen, and Paracetamol, were obtained by in silico research methods.
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Key Findings & Data:With the study results, some critical parameters, such as intestinal-renal absorption of drugs, effects on the central nervous system, binding percentages to plasma proteins, and pure water solubility, were determined.
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Conclusion & Impact:Finally, the highest LD50 values are obtained for Captopril (2078 mg/kg) and Pheniramine maleate (343 mg/kg).
🔬Design:Araştırma Makalesi
📍Scope:2078 Verileri
⚙️Variables:Sık kullanılan önemli acil servis ilaçları · in silico tahminler · ADMET

Abstract

In this paper, pharmacokinetic profiles and toxicity values, also known as ADME parameters, for some drugs frequently used in hospital emergency services, such as Thiocolchicoside, Pheniramine maleate, Captopril, Dexketoprofen, and Paracetamol, were obtained by in silico research methods. With the study results, some critical parameters, such as intestinal-renal absorption of drugs, effects on the central nervous system, binding percentages to plasma proteins, and pure water solubility, were determined. In addition, organ and cell toxicities of each drug were determined in silico, and LD50 values were reported. According to the obtained results, the highest HIA absorption drug is dexketoprofen. Also, paracetamol has the greatest diffusion throughout the circulatory system between all drugs. Finally, the highest LD50 values are obtained for Captopril (2078 mg/kg) and Pheniramine maleate (343 mg/kg).

Özet

Bu çalışmada, hastane acil servislerinde sıklıkla kullanılan Tiyokolşikosid, Feniramin maleat, Kaptopril, Deksketoprofen ve Parasetamol gibi bazı ilaçların farmakokinetik profilleri ve toksisite değerleri, diğer adıyla ADME parametreleri, in silico araştırma yöntemleri ile elde edilmiştir. Çalışma sonuçları ile ilaçların intestinal-renal emilimi, merkezi sinir sistemi üzerindeki etkileri, plazma proteinlerine bağlanma yüzdeleri ve saf suda çözünürlük gibi bazı kritik parametreler belirlenmiştir. Ayrıca her ilacın organ ve hücre toksisiteleri in silico olarak belirlenmiş ve LD50 değerleri raporlanmıştır. Elde edilen sonuçlara göre en yüksek HIA emilimli ilaç deksketoprofendir. Ayrıca parasetamol tüm ilaçlar arasında dolaşım sistemi boyunca en büyük difüzyona sahiptir. Son olarak en yüksek LD50 değerleri Kaptopril (2078 mg/kg) ve Feniramin maleat (343 mg/kg) için elde edilmiştir.

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Cite This Article

Karaman, S. (2025). Investigation of Toxicity and Pharmacokinetic Profiles of Some Frequently Used Drugs in the Emergency Departments. Türk Doğa ve Fen Dergisi, Cilt: 14 Sayı: 4, 203–208. https://doi.org/10.46810/tdfd.1603524

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