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Journals / Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2025 / Cilt: 29 Sayı: 3

Ruthenium-NHC Catalysed N-Alkylation of Pyrrolidine with Alcohols

Pirolidinin Alkollerle Rutenyum-NHC Katalizli N-Alkilasyonu

Nazan Kaloğlu(ADIYAMAN ÜNİVERSİTESİ, TEKNİK BİLİMLER MESLEK YÜKSEKOKULU)0000-0003-3547-4209
Pages
528–537
Publication Date
2025-12-25
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All ruthenium-NHC complexes showed very good catalytic activity under the tested conditions and the targeted N-alkylpyrrolidine products were obtained with high selectivity.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, two new half-sandwich type ruthenium-NHC complexes with the general formula [RuCl2(η6-p-cymene)(NHC)] containing N-heterocyclic carbene (NHC) ligands were synthesised.
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Key Findings & Data:The ruthenium-NHC complexes were used as catalysts in the N-alkylation of pyrrolidine and various alcohol derivatives by hydrogen borrowing strategy.
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Conclusion & Impact:All ruthenium-NHC complexes showed very good catalytic activity under the tested conditions and the targeted N-alkylpyrrolidine products were obtained with high selectivity.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Kataliz · Rutenyum · Pirolidin

Abstract

In this study, two new half-sandwich type ruthenium-NHC complexes with the general formula [RuCl2(η6-p-cymene)(NHC)] containing N-heterocyclic carbene (NHC) ligands were synthesised. The structures of the synthesised complexes were characterised by spectroscopic and analytical methods. The ruthenium-NHC complexes were used as catalysts in the N-alkylation of pyrrolidine and various alcohol derivatives by hydrogen borrowing strategy. The catalytic reactions were carried out in the presence of 1 mol% catalyst loading at 120 °C for 16 h in a solvent-free reaction medium. All ruthenium-NHC complexes showed very good catalytic activity under the tested conditions and the targeted N-alkylpyrrolidine products were obtained with high selectivity.

Özet

Bu çalışmada, N-heterosiklik karben (NHC) ligandı içeren, [RuCl2(η6-p-simen) (NHC)] genel formülüne sahip yarı sandviç tipi iki yeni rutenyum-NHC kompleksi sentezlendi. Sentezlenen komplekslerin yapıları spektroskopik ve analitik yöntemlerle karakterize edildi. Rutenyum-NHC kompleksleri, pirolidin ve çeşitli alkol türevlerinin hidrojen ödünç alma yöntemiyle N-alkilasyonunda katalizör olarak kullanıldı. Katalitik tepkimeler, %1 mol katalizör yüklemesi varlığında 120 °C'de, 16 saatte ve çözücüsüz tepkime ortamında gerçekleştirildi. Tüm rutenyum-NHC kompleksleri, test edilen koşullar altında oldukça iyi katalitik aktivite gösterdi ve hedeflenen N-alkilpirolidin ürünleri yüksek seçicilikte elde edildi.

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Cite This Article

Kaloğlu, N. (2025). Ruthenium-NHC Catalysed N-Alkylation of Pyrrolidine with Alcohols. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 29 Sayı: 3, 528–537. https://doi.org/10.19113/sdufenbed.1607703

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