Journals / Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi / 2026 / Cilt: 14 Sayı: 1

Persistence, distribution, accumulation and health effects of forever chemicals (Per- and Polyfluoroalkyl Substances) in the environment

Per- ve Polifloroalkil maddelerin (sonsuz kimyasalların) çevredeki kalıcılığı, yayılımı, birikimi ve sağlığa etkileri

Pages
412–423
Publication Date
2025-01-15
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

This study addresses the persistence, mobility, transport and accumulation of PFASs in the environment and highlights the potential risks to human health and the importance of monitoring and control measures to be taken accordingly.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Per- and polyfluoroalkyl substances (PFAS) are widely used synthetic chemicals that accumulate persistently in the environment due to their high stability.
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Key Findings & Data:More than 4700 types of PFASs have been produced globally and long-chain types are more persistent than short-chain types, but the toxic risks they may pose in both groups may be similar.
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Conclusion & Impact:This study addresses the persistence, mobility, transport and accumulation of PFASs in the environment and highlights the potential risks to human health and the importance of monitoring and control measures to be taken accordingly.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Ekotoksik · Hareketlilik · Kalıcı kirleticiler

Abstract

Per- and polyfluoroalkyl substances (PFAS) are widely used synthetic chemicals that accumulate persistently in the environment due to their high stability. These substances, which are structurally diverse thanks to their short and long-chain compounds containing a fluorinated hydrophobic tail and a hydrophilic functional group, are used in many industrial and consumer products due to their oil and water repellent properties; however, they carry bioaccumulation and toxicity risks. More than 4700 types of PFASs have been produced globally and long-chain types are more persistent than short-chain types, but the toxic risks they may pose in both groups may be similar. Since their first production in the 1940s, PFASs, which have begun to accumulate in environmental compartments (air-water-soil-biota) and can bioaccumulate in plants and animals, have been understood to have adverse effects on human health, such as cancer, hormonal disorders, and the immune system. Therefore, the control of PFASs and the development of environmental monitoring strategies have gained importance. There are many challenges in detecting, removing and controlling PFASs from the environment that need to be carefully addressed. For future sustainability, PFASs need to be reduced at source, primarily by limiting current PFAS production and shifting consumption patterns towards environmentally friendly products. It is of great importance for understanding and appropriately controlling the future impacts of these forever substances that analytical techniques for measuring PFASs become widespread on a global scale, that PFASs and their by-products are monitored, exposure and toxicity levels are revealed, risk assessments are made and PFASs are managed by providing control at every level from their sources to their disposal. This study addresses the persistence, mobility, transport and accumulation of PFASs in the environment and highlights the potential risks to human health and the importance of monitoring and control measures to be taken accordingly.

Özet

Per- ve polifloroalkil maddeler (PFAS) her alanda yaygın kullanılan ve yüksek kararlılıkları nedeniyle de çevrede kalıcı halde biriken sentetik kimyasallardır. Florlanmış hidrofobik bir kuyruk ve hidrofilik bir fonksiyonel grup içeren kısa ve uzun zincirli bileşikleri sayesinde yapısal olarak çok çeşitli olan bu maddeler, yağ ve su itici özellikleri nedeniyle birçok endüstriyel ve tüketici ürününde yer almakta; ancak canlılarda biyobirikim ve toksisite riskleri taşımaktadır. Küresel ölçekte 4700’den fazla türü üretilmiş olan PFAS'ların uzun zincirli türleri kısa zincirlilere göre daha kalıcıdır, ancak iki grubunda oluşturabileceği toksik riskler benzer olabilmektedir. 1940’lardaki ilk üretiminden bu yana çevresel ortamlarda (hava-su-toprak-biyota) birikmeye başlayan, bitkilerde ve hayvanlarda biyokümüle olabilen PFAS’ların, insan sağlığı üzerinde kanser, hormonal bozukluklar ve bağışıklık sistemi üzerinde olumsuz etkiler sergilediği anlaşılmıştır. Bu nedenle PFAS'ların kontrolü ve çevresel izleme stratejilerinin geliştirilmesi önem kazanmıştır. PFAS’ların tespitinde, çevreden uzaklaştırılmasında ve kontrolünde dikkatle ele alınması gereken birçok zorluk bulunmaktadır. Gelecekte sürdürülebilirlik açısından, öncelikle mevcut PFAS üretimi sınırlandırılıp tüketim alışkanlıkları çevre dostu ürünlere kaydırılarak PFAS’ların kaynakta azaltılması gereklidir. PFAS’ların ölçülmesiyle ilgili analitik tekniklerin küresel ölçekte yaygınlaşması ve geliştirilmesi, PFAS’ların ve yan ürünlerinin izlenmesi, maruziyet ve toksisite seviyelerinin ortaya çıkarılması, risk değerlendirmelerinin yapılması, PFAS’ların kaynaklarından bertarafına kadar her kademede kontrol sağlanarak yönetilmesi, bu sonsuz maddelerin gelecekteki etkilerinin anlaşılabilmesi ve uygun şekilde kontrol edilmesi açısından büyük önem taşımaktadır. Bu çalışma, PFAS'ların çevredeki kalıcılığını, hareketliliğini, taşınım ve birikimini ele alarak insan sağlığı üzerindeki potansiyel riskleri ve bu doğrultuda alınması gereken izleme ve kontrol önlemlerinin önemini vurgulamaktadır.

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Cite This Article

Yurtsever, M. (2025). Persistence, distribution, accumulation and health effects of forever chemicals (Per- and Polyfluoroalkyl Substances) in the environment. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi, Cilt: 14 Sayı: 1, 412–423. https://doi.org/10.28948/ngumuh.1537421

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References (87)

  1. H. Rekik, H., Pichon, L., M.A. El Khakani, P. Drogui, Per-and polyfluoroalkyl (PFAS) Eternal pollutants: sources, environmental impacts and treatment processes. Chemosphere, 142044, 2024. https://doi.org /10.1016/j.chemosphere.2024.142044
  2. A.B. Lindstrom, M.J. Strynar, E.L. Libelo, Polyfluorinated compounds: past, present, and future, Environmental Science & Technology, 45(19), 7954-7961, 2011. https://doi.org/10.1021/es2011622
  3. S. Shabanian, S.K. Lahiri, M. Soltani, K. Golovin, Durable water-and oil-repellent textiles without long-or short-chain perfluoroalkylated substances. Materials Today Chemistry, 34, 101786, 2023. https://doi.org/10.1016/j.mtchem.2023.101786
  4. M. Mohseni, S.K. Lahiri, A.V. Nadaraja, U. Sundararaj, K. Golovin, Durable and comfortable superoleophobic fabrics utilizing ultra-short-chain fluorinated surface chemistry. Chemical Engineering Journal, 471, 144726, 2023. https://doi.org/10.1016/j.c ej.2023.144726
  5. K.E. Pelch, A. Reade, C.F. Kwiatkowski, F.M. Merced-Nieves, H. Cavalier, K. Schultz, J. Varshavsky, The PFAS-Tox Database: A systematic evidence map of health studies on 29 per-and polyfluoroalkyl substances. Environment International, 167, 107408, 2022. https://doi.org/10.1016/j.envint.20 22.107408
  6. EPA, PFAS Strategic Roadmap: EPA's Commitments to Action 2021-2024, https://www.epa.gov/pfas/pfas-strategic-roadmap-epas-commitments-action-2021-2024, Erişim Tarihi: 10/05/2024.
  7. V. Gómez, M. Torres, P. Karásková, P. Přibylová, J. Klánová, K. Pozo, Occurrence of perfluoroalkyl substances (PFASs) in marine plastic litter from coastal areas of Central Chile. Marine Pollution Bulletin, 172, 112818, 2021. https://doi.org/10.1016/j.marpolbul.20 21.112818
  8. OECD, Classification of per-and polyfluoroalkyl substances (PFASs), 2021, https://www.oecd.org/che micalsafety/portal-perfluori nated-chemicals/aboutpfa ss/Figure1-classification-of-per-and-polyfluoroalkyl-substances%20-PFASs.pdf, Erişim Tarihi: 12/01/2024.
  9. Geosyntec Consultants of North Carolina, Assessment of the Chemical and Spatial Distribution of PFAS in the Cape Fear River, Project Number TR0726, 2018, https://www.chemours.com/en//media/files/corporate/ pfas-characterization-quarterly-report-january-2020.p df, Erişim Tarihi: 10 Ocak 2024.
  10. J.P. Antle, M.A. LaRock, Z. Falls, C. Ng, G.E. Atilla-Gokcumen, D.S. Aga, S.M. Simpson, Building Chemical Intuition about Physicochemical Properties of C8-Per-/Polyfluoroalkyl Carboxylic Acids through Computational Means. ACS ES&T Engineering, 4(1), 196-208, 2023. https://doi.org/10.1021/acsestengg.3c0 0267
  11. A. He, Y. Liang, F. Li, Y. Lu, C. Liu, J. Li, G. Jiang, Vital environmental sources for multitudinous fluorinated chemicals: new evidence from industrial byproducts in multienvironmental matrices in a fluorochemical manufactory. Environmental Science & Technology, 56(23), 16789-16800, 2022. https://doi. org/10.1021/acs.est.2c04372
  12. D. Zhang, J. Li, X. Li, M. Wang, Y. Zhong, G. Chen, Y. Zhang, Phytoremediation of fluoroalkylethers (ether-PFASs): A review on bioaccumulation and ecotoxicological effects. Science of The Total Environment, 865, 161260, 2023. https://doi.org/10.1016/j.scitotenv.2022.161260
  13. F.A. Zeidabadi, E.B. Esfahani, M. Mohseni, Effects of Water Matrix on Per-and Poly-fluoroalkyl Substances (PFAS) Treatment: Physical-separation and Degradation Processes—A review. Journal of Hazardous Materials Advances, 100322, 2023. https:// doi.org/10.1016/j.hazadv.2023.100322
  14. M. Ateia, M. Arifuzzaman, S. Pellizzeri, M.F. Attia, N. Tharayil, J.N. Anker, T. Karanfil, Cationic polymer for selective removal of GenX and short-chain PFAS from surface waters and wastewaters at ng/L levels. Water Research, 163, 114874, 2019. https://doi.org/10.1016 /j.watres.2019.114874
  15. G. Munoz, J. Liu, S.V. Duy, S. Sauvé, Analysis of F-53B, Gen-X, ADONA, and emerging fluoroalkylether substances in environmental and biomonitoring samples: A review. Trends in Environmental Analytical Chemistry, 23, e00066, 2019. https://doi. org/10.1016/j.teac.2019.e00066
  16. R. Dhore, G.S. Murthy, Per/polyfluoroalkyl substances production, applications, and environmental impacts. Bioresource Technology, 341, 125808, 2021. https:// doi.org/10.1016/j.biortech.2021.125808
  17. C.F. Kwiatkowski, D.Q. Andrews, L.S. Birnbaum, T.A. Bruton, J.C. DeWitt, D.R. Knappe, A. Blum, Scientific basis for managing PFAS as a chemical class. Environmental Science & Technology Letters, 7(8), 532-543, 2020. https://doi.org/10.1021/acs.estlett.0c00 255
  18. M. Dadashi Firouzjaei, E. Zolghadr, S. Ahmadalipour, N. Taghvaei, F. Akbari Afkhami, S. Nejati, M.A. Elliott, Chemistry, abundance, detection and treatment of per-and polyfluoroalkyl substances in water: a review. Environmental Chemistry Letters, 20(1), 661-679, 2022. https://doi.org/10.1007/s10311-021-01340-6
  19. A. Habib, E.N. Landa, K.L. Holbrook, W.S. Walker, W.Y. Lee, Rapid, efficient, and green analytical technique for determination of fluorotelomer alcohol in water by stir bar sorptive extraction. Chemosphere, 338, 139439, 2023. https://doi.org/10.1016/j.chemos phere.2023.139439
  20. M.N. Goukeh, T. Abichou, Y. Tang, Measurement of fluorotelomer alcohols based on solid phase microextraction followed by gas chromatography-mass spectrometry and its application in solid waste study. Chemosphere, 345, 140460, 2023. https://doi.org/10. 1016/j.chemosphere.2023.140460
  21. B. Ameduri, Fluoropolymers: A special class of per-and polyfluoroalkyl substances (PFASs) essential for our daily life. Journal of Fluorine Chemistry, 267, 110117, 2023. https://doi.org/10.1016/j.jfluchem.2023.110117
  22. K.R. Miner, H. Clifford, T. Taruscio, M. Potocki, G. Solomon, M. Ritari, P.A. Mayewski, Deposition of PFAS 'forever chemicals' on Mt. Everest. Science of the Total Environment, 759, 144421, 2021. https://doi.org/10.1016/j.scitotenv.2020.144421
  23. T. Zhou, X. Li, H. Liu, S. Dong, Z. Zhang, Z. Wang, Q. Wang, Occurrence, fate, and remediation for per-and polyfluoroalkyl substances (PFAS) in sewage sludge: A comprehensive review. Journal of Hazardous Materials, 133637, 2024. https://doi.org/10.1016/j.jhaz mat.2024.133637
  24. A. Sanchez-Vidal, M. Llorca, M. Farré, M. Canals, D. Barceló, P. Puig, A. Calafat, Delivery of unprecedented amounts of perfluoroalkyl substances towards the deep-sea. Science of The Total Environment, 526, 41-48, 2015. https://doi.org/10.1016/j.scitotenv.2015.04.080
  25. D. Zhang, J. Li, X. Li, M. Wang, Y. Zhong, G. Chen, Y. Zhang, Phytoremediation of fluoroalkylethers (ether-PFASs): A review on bioaccumulation and ecotoxicological effects. Science of The Total Environment, 865, 161260, 2023. https://doi.org/10.1016/j.scitotenv.2022.161260
  26. Y. Shen, L. Wang, Y. Ding, S. Liu, Y. Li, Z. Zhou, Y. Liang, Trends in the analysis and exploration of per-and polyfluoroalkyl substances (PFAS) in environmental matrices: A review. Critical Reviews in Analytical Chemistry, 1-25, 2023. https://doi.org/10. 1080/10408347.2023.2231535
  27. A.F. Peritore, E. Gugliandolo, S. Cuzzocrea, R. Crupi, D. Britti, Current Review of Increasing Animal Health Threat of Per-and Polyfluoroalkyl Substances (PFAS): Harms, Limitations, and Alternatives to Manage Their Toxicity. International Journal of Molecular Sciences, 24(14), 11707, 2023. https://doi.org/10.3390/ijms2414 11707
  28. F.G. Torres, G.E. De-la-Torre, Per-and polyfluoroalkyl substances (PFASs) in consumable species and food products. Journal of Food Science and Technology, 60(9), 2319-2336, 2023. https://doi.org/10.1007/s1319 7-022-05545-7
  29. T. Groffen, H. Keirsebelik, H. Dendievel, M. Falcou-Préflo, L. Bervoets, J. Schoelynck, Are Chinese mitten crabs (Eriocheir sinensis) suitable as biomonitor or bioindicator of per-and polyfluoroalkyl substances (PFAS) pollution?. Journal of Hazardous Materials, 464, 133024, 2024. https://doi.org/10.1016/j.jhazmat. 2023.133024
  30. C. Vendl, M.D. Taylor, J. Bräunig, L. Ricolfi, R. Ahmed, M. Chin, S. Nakagawa, Profiling research on PFAS in wildlife: Systematic evidence map and bibliometric analysis. Ecological Solutions and Evidence, 5(1), e12292, 2024. https://doi.org/10.1002/ 2688-8319.12292
  31. S. Tartu, S. Bourgeon, J. Aars, M. Andersen, K. Lone, B.M. Jenssen, H. Routti, Diet and metabolic state are the main factors determining concentrations of perfluoroalkyl substances in female polar bears from Svalbard. Environmental Pollution, 229, 146-158, 2017. https://doi.org/10.1016/j.envpol.2017.04.100
  32. K. Lee, J.J. Alava, P. Cottrell, L. Cottrell, R. Grace, I. Zysk, S. Raverty, Emerging Contaminants and New POPs (PFAS and HBCDD) in Endangered Southern Resident and Bigg's (Transient) Killer Whales (Orcinus orca): In Utero Maternal Transfer and Pollution Management Implications. Environmental Science & Technology, 57(1), 360-374, 2022. https://doi.org/10. 1021/acs.est.2c04126
  33. M. Marín-García, C. Fàbregas, C. Argenté, J. Díaz-Ferrero, C. Gómez-Canela, Accumulation and dietary risks of perfluoroalkyl substances in fish and shellfish: A market-based study in Barcelona. Environmental Research, 237, 117009, 2023. https://doi.org/10.1016/ j.envres.2023.117009
  34. K.E. Hopkins, M.A. McKinney, A. Saini, R.J. Letcher, N.K. Karouna-Renier, K.J. Fernie, Characterizing the Movement of Per-and Polyfluoroalkyl Substances in an Avian Aquatic-Terrestrial Food Web. Environmental Science & Technology, 57(48), 20249-20260, 2023. https://doi.org/10.1021/acs.est.3c06944
  35. S.E. George, T.R. Baker, B.B. Baker, Nonlethal detection of PFAS bioaccumulation and biomagnification within fishes in an urban-and wastewater-dominant Great Lakes watershed. Environmental Pollution, 321, 121123, 2023. https:// doi.org/10.1016/j.envpol.2023.121123
  36. L. Lesmeister, F.T. Lange, J. Breuer, A. Biegel-Engler, E. Giese, M. Scheurer, Extending the knowledge about PFAS bioaccumulation factors for agricultural plants a review. Science of The Total Environment, 766, 142640, 2021. https://doi.org/10.1016/j.scitotenv.2020.142640
  37. W. Nassazzi, T.C. Wu, J. Jass, F.Y. Lai, L. Ahrens, Phytoextraction of per-and poly-fluoroalkyl substances (PFAS) and the influence of supplements on the performance of short-rotation crops. Environmental Pollution, 122038, 2023. https://doi.org/10.1016/j.env pol.2023.122038
  38. E. Kavusi, B.S.K. Ansar, S. Ebrahimi, R. Sharma, S.S. Ghoreishi, K. Nobaharan, T. Astatkie, Critical review on phytoremediation of polyfluoroalkyl substances from environmental matrices: Need for global concern. Environmental Research, 217, 114844, 2023. https:// doi.org/10.1016/j.envres.2022.114844
  39. R. Ghisi, T. Vamerali, S. Manzetti, Accumulation of perfluorinated alkyl substances (PFAS) in agricultural plants: A review. Environmental Research, 326-341, 2019. https://doi.org/10.1016/j.envres.2018.10.02 3
  40. M.C.S. Costello, L.S. Lee, Sources, fate, and plant uptake in agricultural systems of per-and polyfluoroalkyl substances. Current Pollution Reports, 1-21, 2020. https://doi.org/10.1007/s40726-020-00168 -y
  41. Z. Liu, Y. Lu, Y. Shi, P. Wang, K. Jones, A.J. Sweetman, K. Khan, Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China. Environment International, 106, 37-47, 2017. https://doi.org/10.1016/j.envint.2017.05.014
  42. H. Jin, G. Shan, L. Zhu, H. Sun, Y. Luo, Perfluoroalkyl acids including isomers in tree barks from a Chinese fluorochemical manufacturing park: implication for airborne transportation. Environmental Science & Technology, 52(4), 2016-2024, 2018. https://doi.org /10.1021/acs.est.7b06241
  43. M. Berthou, V. Gérard, M. Pélingre, A. Bagard, T.L. Batteux, G. Losfeld, Is it raining PFAS in France? An analysis of 52 PFAS at nanogram per liter levels in French rainwaters during autumn season. Journal of Environmental Quality, 53(1), 123-132, 2024. https:// doi.org/10.1002/jeq2.20525
  44. O. Adu, X. Ma, V.K. Sharma, Bioavailability, phytotoxicity and plant uptake of per-and polyfluoroalkyl substances (PFAS): A review. Journal of Hazardous Materials, 447, 130805, 2023. https:// doi.org/10.1016/j.jhazmat.2023.130805
  45. S.E. Fenton, A. Ducatman, A. Boobis, J.C. DeWitt, C. Lau, C. Ng, S.M. Roberts, Per-and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research. Environmental Toxicology and Chemistry, 40(3), 606-630, 2021. https://doi.org/10.1002/etc.4890
  46. A. Podder, A.A. Sadmani, D. Reinhart, N.B. Chang, R. Goel, Per-and poly-fluoroalkyl substances (PFAS) as a contaminant of emerging concern in surface water: a transboundary review of their occurrences and toxicity effects. Journal of Hazardous Materials, 419, 126361, 2021. https://doi.org/10.1016/j.jhazmat.2021.126361
  47. EPA, Our Current Understanding of Human Health and Environmental Risks from PFAS, 2023, https://www.epa.gov/pfas/our-current-und erstanding-human-health-and-environmental-risks-pfas Erişim Tarihi: 18/03/2024.
  48. F.M. Hekster, R.W. Laane, P. De Voogt, Environmental and toxicity effects of perfluoroalkylated substances. Reviews of Environmental Contamination and Toxicology, vol 179. Springer, New York, NY. https://doi.org/10.1007/ 0-387-21731-2_4
  49. K. Nahar, N.A. Zulkarnain, R.K. Niven, A review of analytical methods and technologies for monitoring per-and polyfluoroalkyl substances (PFAS) in water. Water, 15(20), 3577, 2023. https://doi.org/10.3390/w1 5203577
  50. Z. Abunada, M.Y. Alazaiza, M.J. Bashir, An overview of per-and polyfluoroalkyl substances (PFAS) in the environment: Source, fate, risk and regulations. Water, 12(12), 2020. https://doi.org/10.3390/w1212359 0
  51. CDC, National Health and Nutrition Examination Survey, 2023, https://www.cdc.gov/nchs/nhanes/index.htm Erişim Tarihi: 05/11/2023.
  52. A.M. Calafat, L.Y. Wong, Z. Kuklenyik, J.A. Reidy, L.L. Needham, Polyfluoroalkyl chemicals in the US population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environmental Health Perspectives, 115(11), 1596-1602, 2007. https://doi.org/10.1289/ehp.1059
  53. J.M. Graber, C. Alexander, R.J. Laumbach, K. Black, P.O. Strickland, P.G. Georgopoulos, C.P. Weisel, Per-and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013-2014 NHANES. Journal of Exposure Science & Environmental Epidemiology, 29(2), 172-182, 2019. https://doi.org/10.1038/s41370-018-0096-z
  54. I. Rosato, T. Bonato, T. Fletcher, E. Batzella, C. Canova, Estimation of per-and polyfluoroalkyl substances (PFAS) half-lives in human studies: A systematic review and meta-analysis. Environmental Research, 117743, 2023. https://doi.org/10.1016/j.envr es.2023.117743
  55. K. Abraham, B.H. Monien, Transdermal absorption of 13C4-perfluorooctanoic acid (13C4-PFOA) from a sunscreen in a male volunteer—What could be the contribution of cosmetics to the internal exposure of perfluoroalkyl substances (PFAS)?. Environment International, 169, 107549, 2022. https://doi.org/10.1016/j.envint.2022.107549
  56. J. Marchiandi, W. Alghamdi, S. Dagnino, M.P. Green, B.O. Clarke, Exposure to endocrine disrupting chemicals from beverage packaging materials and risk assessment for consumers. Journal of Hazardous Materials, 465, 133314, 2024. https://doi.org/10.1016/j.jhazmat.2023.133314
  57. H.P. Susmann, L.A. Schaider, K.M. Rodgers, R.A. Rudel, Dietary habits related to food packaging and population exposure to PFASs. Environmental Health Perspectives, 127(10), 107003, 2019. https://doi.org /10.1289/EHP40
  58. IPEN, Single-Use Food Packaging in 17 Countries Contains PFAS “Forever Chemicals”, 2023, https://ipen.org/news/single-use-food-packaging-17-countries-contains-pfas- Erişim Tarihi: 23/05/2024
  59. R.A. Wicker, To Dye For: How Toxic Fashion Is Making Us Sick—and How We Can Fight Back, Penguin Publishing Group, ISBN: 0593422619, 9780593422618, USA, 2023.
  60. Q. Sun, T. Wang, X. Zhan, S. Hong, L. Lin, P. Tan, J.S. Khim, Legacy and novel perfluoroalkyl substances in raw and cooked squids: Perspective from health risks and nutrient benefits. Environment International, 108024, 2023. https://doi.org/10.1016/j.envint.2023. 108024
  61. J.T. Thompson, B. Chen, J.A. Bowden, T.G. Townsend, Per-and polyfluoroalkyl substances in toilet paper and the impact on wastewater systems. Environmental Science & Technology Letters, 10(3), 234-239, 2023. https://doi.org/10.1021/acs.estlett.3c00 094
  62. D.K. Essumang, A. Eshun, J.N. Hogarh, J.K. Bentum, J.K. Adjei, J. Negishi, S. Masunaga, Perfluoroalkyl acids (PFAAs) in the Pra and Kakum River basins and associated tap water in Ghana. Science of the Total Environment, 579, 729-735, 2017. https://doi.org/10. 1016/j.scitotenv.2016.11.035
  63. Y. Shiwaku, P. Lee, P. Thepaksorn, B. Zheng, A. Koizumi, K.H. Harada, Spatial and temporal trends in perfluorooctanoic and perfluorohexanoic acid in well, surface, and tap water around a fluoropolymer plant in Osaka, Japan. Chemosphere, 164, 603-610, 2016. https://doi.org/10.1016/j.chemosphere.2016.09.006
  64. D. Cserbik, M. Casas, C. Flores, A. Paraian, L.S. Haug, I. Rivas, C.M. Villanueva, Concentrations of per-and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy. Journal of Exposure Science & Environmental Epidemiology, 34(1), 90-96, 2024. https://doi.org/10.1038/s41370-02 3-00581-7
  65. J. Li, W. Duan, Z. An, Z. Jiang, L. Li, M. Guo, H. Guo, Legacy and alternative per-and polyfluoroalkyl substances spatiotemporal distribution in China: human exposure, environmental media, and risk assessment. Journal of Hazardous Materials, 135795, 2024. https://doi.org/10.1016/j.jhazmat.2024.135795
  66. European Environment Agency (EEA), Zero Pollution: Cross-Cutting Stories, PFAS, https://www.eea.europa. eu/publications/zero-pollutioncross-cutting-stories/pfa s Erişim Tarihi: 12/12/2023.
  67. B. Göckener, T. Weber, H. Rüdel, M. Bücking, M. Kolossa-Gehring, Human biomonitoring of per-and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019. Environment International, 145, 106123, 2020. https://doi.org/10.1016/j.envint.20 20.106123
  68. C. Schröter-Kermani, J. Müller, H. Jürling, A. Conrad, C. Schulte, Retrospective monitoring of perfluorocarboxylates and perfluorosulfonates in human plasma archived by the German Environmental Specimen Bank. International Journal of Hygiene and Environmental Health, 216(6), 633-640, 2013. https://doi.org/10.1016/j.ijheh.2012.08.004
  69. J.M. Conley, C.S. Lambright, N. Evans, M.J. Strynar, J. McCord, B.S. McIntyre, L.E. Gray Jr, Adverse maternal, fetal, and postnatal effects of hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague-Dawley rats. Environmental Health Perspectives, 127(3), 037008, 2019. https://doi.org/10.1289/EHP437
  70. J.C. Rae, L. Craig, T.W. Slone, S.R. Frame, L.W. Buxton, G.L. Kennedy, Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague-Dawley rats. Toxicology Reports, 2, 939-949, 2015. https://doi.org/10.1016/j.toxrep.2015.06.001
  71. National Toxicology Program (NTP), NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (HsdDawley SD) Rats, Toxicity Report 97, 2022. https://www.ncbi.nlm.nih.gov/books/ NBK551546/ https://doi.org/10.22427/NTP-TOX-97
  72. B.J. Henry, J.P. Carlin, J.A. Hammerschmidt, R.C. Buck, L.W. Buxton, H. Fiedler, O. Hernandez, A critical review of the application of polymer of low concern and regulatory criteria to fluoropolymers. Integrated Environmental Assessment and Management, 14(3), 316-334, 2018. https://doi.org/10.1002/ieam.4035
  73. S.H. Korzeniowski, R.C. Buck, R.M. Newkold, A.E. Kassmi, E. Laganis, Y. Matsuoka, S. Musio, A critical review of the application of polymer of low concern regulatory criteria to fluoropolymers II: fluoroplastics and fluoroelastomers. Integrated Environmental Assessment and Management, 19(2), 326-354, 2023. https://doi.org/10.1002/ieam.4646
  74. G.O. Sebe, E.V. Anyaogu, A.D.A.R.C. Ntomchukwu, S.O. Oghenerhoro, O.E. Jonathan, Health Impacts and Mechanisms of Per-and Polyfluoroalkyl Substances (PFAS) from Epidemiological to Toxicological. J. of Biosciences and Medicines, 11(12), 218-240, 2023. https://doi.org/10.4236/jbm.2023.1112018
  75. M. Nian, K. Luo, F. Luo, R. Aimuzi, X. Huo, Q. Chen, J. Zhang, Association between prenatal exposure to PFAS and fetal sex hormones: are the short-chain PFAS safer?. Environmental Science & Technology, 54(13), 8291-8299, 2020. https://doi.org/10.1021/acs.est.0c02444
  76. K. Lucas, L.G. Gaines, T. Paris-Davila, L.A. Nylander-French, Occupational exposure and serum levels of per-and polyfluoroalkyl substances (PFAS): A review. American Journal of Industrial Medicine, 66(5), 379-392, 2023. https://doi.org/10.1002/ajim.23454
  77. J. John, F. Coulon, P.V. Chellam, Detection and treatment strategies of per-and polyfluoroalkyl substances (PFAS): Fate of PFAS through DPSIR framework analysis. Journal of Water Process Engineering, 45, 102463, 2022. https://doi.org/10.1016/j.jwpe.2021.102463
  78. B. Saawarn, B. Mahanty, S. Hait, S. Hussain, Sources, occurrence, and treatment techniques of per-and polyfluoroalkyl substances in aqueous matrices: A comprehensive review. Environmental Research, 214, 114004, 2022. https://doi.org/10.1016/j.envres.2022. 114004
  79. N. Rhakho, S. Yadav, M. Jinagi, A. Altaee, M. Saxena, A.H. Jadhav, A.K. Samal, Mitigating PFAS Contaminants in Water: A Comprehensive Survey of Remediation Strategies. Journal of Environmental Chemical Engineering, 113425, 2024. https://doi.org /10.1016/j.jece.2024.113425
  80. S. Shabanian, S.K. Lahiri, M. Soltani, K. Golovin, Durable water-and oil-repellent textiles without long-or short-chain perfluoroalkylated substances. Materials Today Chemistry, 34, 101786, 2023. https://doi.org/10.1016/j.mtchem.2023.101786
  81. B. Ameduri, Fluoropolymers: A special class of per-and polyfluoroalkyl substances (PFASs) essential for our daily life. Journal of Fluorine Chemistry, 267, 110117, 2023. https://doi.org/10.1016/j.jfluchem.2023.110117
  82. K.R. Miner, H. Clifford, T. Taruscio, M. Potocki, G. Solomon, M. Ritari, P.A. Mayewski, Deposition of PFAS 'forever chemicals' on Mt. Everest. Science of the Total Environment, 759, 144421, 2021. https://doi.org/10.1016/j.scitotenv.2020.144421
  83. L. Lesmeister, F.T. Lange, J. Breuer, A. Biegel-Engler, E. Giese, M. Scheurer, Extending the knowledge about PFAS bioaccumulation factors for agricultural plants a review. Science of The Total Environment, 766, 142640, 2021. https://doi.org/10.1016/j.scitotenv.2020.142640
  84. CDC, National Health and Nutrition Examination Survey, 2023, https://www.cdc.gov/nchs/nhanes/index.htm Erişim Tarihi: 05/11/2023.
  85. I. Rosato, T. Bonato, T. Fletcher, E. Batzella, C. Canova, Estimation of per-and polyfluoroalkyl substances (PFAS) half-lives in human studies: A systematic review and meta-analysis. Environmental Research, 117743, 2023. https://doi.org/10.1016/j.envr es.2023.117743
  86. B.J. Henry, J.P. Carlin, J.A. Hammerschmidt, R.C. Buck, L.W. Buxton, H. Fiedler, O. Hernandez, A critical review of the application of polymer of low concern and regulatory criteria to fluoropolymers. Integrated Environmental Assessment and Management, 14(3), 316-334, 2018. https://doi.org/10.1002/ieam.4035
  87. M. Nian, K. Luo, F. Luo, R. Aimuzi, X. Huo, Q. Chen, J. Zhang, Association between prenatal exposure to PFAS and fetal sex hormones: are the short-chain PFAS safer?. Environmental Science & Technology, 54(13), 8291-8299, 2020. https://doi.org/10.1021/acs.est.0c02444