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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 11 Issue: 1

Prolidase Enzyme Activity in Endometrial Polyps and Its Relationship with Oxidative Stress

Endometriyal Poliplerde Prolidaz Enzim Aktivitesi ve Oksidatif Stres ile İlişkisi

Farida Hajıbayli(Haliç University Avcılar Hospital, Obstetrics and Gynecology Department)0000-0001-7760-0088
Mehmet Ferdi Kıncı(Tepecik Education and Research Hospital, Obstetrics and Gynecology Department)0000-0002-6798-4281
Burak Sezgin(MUGLA SITKI KOCMAN UNIVERSITY)0000-0003-2938-5816
Burcu Kasap(MUGLA SITKI KOCMAN UNIVERSITY)0000-0002-1768-5320
Ercan Saruhan(MUGLA SITKI KOCMAN UNIVERSITY)0000-0001-6416-1442
Ahmet Akın Sivaslıoğlu(İzmir Ekonomi University Medical Point Hospital, Obstetrics and Gynecology Department)0000-0003-3711-0118
Pages
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Publication Date
2024-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We believe that our study, when supported by studies with larger patient groups, may be a useful marker for a more detailed understanding of the pathogenesis and clinical follow-up of patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Endometrial polyp (EP) is a condition that is often encountered in obstetrics and gynecology clinic practices.
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Key Findings & Data:Thirty-five patients who were histopathologically diagnosed with EP and 35 patients with abnormal uterine bleeding (AUB) without pathology as a result of endometrial sampling were included in the control group.
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Conclusion & Impact:We believe that our study, when supported by studies with larger patient groups, may be a useful marker for a more detailed understanding of the pathogenesis and clinical follow-up of patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Endometrial Polyp · Oxidative Stress · Prolidase Enzyme Activity

Abstract

Endometrial polyp (EP) is a condition that is often encountered in obstetrics and gynecology clinic practices. In our study, we aimed to reveal the relationship between prolidase enzyme activity (PEA) and Oxidative Stress (OS) in patients with endometrial polyps. Thirty-five patients who were histopathologically diagnosed with EP and 35 patients with abnormal uterine bleeding (AUB) without pathology as a result of endometrial sampling were included in the control group. Serum TOS, OSI, tissue PEA, and endometrial thickness values were found to be statistically significantly higher in the EP group compared to the control group. We believe that our study, when supported by studies with larger patient groups, may be a useful marker for a more detailed understanding of the pathogenesis and clinical follow-up of patients.

Özet

Endometrial polip (EP) kadın hastalıkları ve doğum kliniği pratiğinde sıklıkla karşılaşılan bir durumdur. Biz çalışmamızda endometrial polip tanısı olan hastaların prolidaz enzim aktivitesi ve oksidatif stres (OS) ile ilişkisini ortaya çıkarmayı amaçladık. Araştırmaya dahil edilme kriterlerini karşılayan histopatolojik olarak EP tanısı konan 35 hasta ile endometrial örnekleme sonucunda patoloji tespit edilmeyen 35 anormal uterin kanaması (AUK) olan kontrol grubu hastası dahil edilmiştir. EP ve kontrol grupları arasında TAS, TOS, OSI, prolidaz ve endometrium kalınlığı değerleri karşılaştırıldığında EP grubunda, kontrol grubuna göre TOS, OSI, prolidaz ve endometrial kalınlık değerleri istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Çalışmamız, daha geniş hasta grupları ile yapılan çalışmalarla desteklendiğinde patogenezin daha ayrıntılı anlaşılması ve klinik olarak hasta takibinde yararlı bir belirteç olabileceği görüşündeyiz.

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Cite This Article

Hajıbayli, F., Kıncı, M. F., Sezgin, B., Kasap, B., Saruhan, E., Sivaslıoğlu, A. A. (2024). Prolidase Enzyme Activity in Endometrial Polyps and Its Relationship with Oxidative Stress. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 11 Issue: 1. https://doi.org/10.47572/muskutd.1370002

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