Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 1

Rarely Observed Tonsil Diffuse Large B-Cell Lymphoma: A Case Report of 63-Year-Old Male Patient

Ömer Faruk Güzel(Muğla Eğitim ve Araştıma Hastanesi)0000-0001-7221-0152
Furkan Yavuz(MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0008-3889-726X
Pages
—
Publication Date
2026-04-29
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, non-Hodgkin lymphomas originating in the tonsils, particularly in the head and neck region, may present with non-specific symptoms, resulting in diagnostic delays.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Tonsil lymphomas represent an important subgroup of non-Hodgkin lymphomas in the head and neck region.
📊
Key Findings & Data:This case report describes the diagnostic process and management of Diffuse Large B-Cell Lymphoma (DLBCL) in a 63-year-old male patient.
💡
Conclusion & Impact:In conclusion, non-Hodgkin lymphomas originating in the tonsils, particularly in the head and neck region, may present with non-specific symptoms, resulting in diagnostic delays.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Diffuse Large B-Cell Lymphoma · Head and Neck Neoplasms · Tonsil

Abstract

Tonsil lymphomas represent an important subgroup of non-Hodgkin lymphomas in the head and neck region. They often present with non-specific symptoms such as sore throat and difficulty swallowing, which may lead to misdiagnosis and delayed treatment. This case report describes the diagnostic process and management of Diffuse Large B-Cell Lymphoma (DLBCL) in a 63-year-old male patient. The patient had a two-month history of persistent sore throat and dysphagia despite treatment. Physical examination revealed a significant mass in the right tonsil. Initial evaluation and incisional biopsy suggested squamous cell carcinoma; however, excisional biopsy confirmed the diagnosis of DLBCL. The non-specific presentation complicated the clinical assessment and contributed to delayed diagnosis. Diagnostic challenges of tonsil lymphomas are well documented; they are frequently confused with infections or carcinomas, and incisional biopsies may not provide sufficient specificity or sensitivity to guide therapy. This case emphasizes the importance of further investigation when symptoms do not resolve with initial treatment and demonstrates the critical role of excisional biopsy in establishing a definitive diagnosis. In conclusion, non-Hodgkin lymphomas originating in the tonsils, particularly in the head and neck region, may present with non-specific symptoms, resulting in diagnostic delays. Early recognition, biopsy, and a multidisciplinary management approach are essential for timely and effective treatment. This report highlights the need for clinical vigilance and appropriate diagnostic strategies to improve patient outcomes in tonsillar DLBCL.

Özet

Tonsil lenfomaları, baş ve boyun bölgesindeki non-Hodgkin lenfomaların önemli bir alt grubunu temsil etmektedir. Genellikle boğaz ağrısı ve yutma güçlüğü gibi spesifik olmayan semptomlarla başvurarak yanlış tanı ve tedavi gecikmesine yol açabilmektedirler. Bu olgu sunumu, 63 yaşındaki bir erkek hastada Diffüz Büyük B-Hücreli Lenfoma (DLBCL) tanı sürecini ve yönetimini detaylandırmaktadır. Hasta, tedaviye rağmen iki aydır devam eden boğaz ağrısı ve disfaji şikâyeti ile başvurmuştur. Fizik muayenede sağ tonsilde belirgin bir kitle saptanmıştır. İlk değerlendirme ve insizyonel biyopsi lezyonun skuamöz hücreli karsinom olabileceğini düşündürmüş; ancak eksizyonel biyopsi DLBCL tanısını doğrulamıştır. Spesifik olmayan klinik tablo, tanı sürecini zorlaştırmış ve tanının gecikmesine sebep olmuştur. Tonsil lenfomalarının tanısındaki güçlükler literatürde belirtilmiş olmakla beraber bu lenfomalar sıklıkla enfeksiyonlar veya karsinomlarla karıştırılmakta ve insizyonel biyopsiler her zaman tedaviye yönlendirmek için yeterli özgüllük veya duyarlılık sağlayamayabilmektedir. Bu olgu, semptomlar ilk tedaviye rağmen düzelmediğinde ileri araştırmanın önemini ve eksizyonel biyopsinin kesin tanı konulmasındaki kritik rolünü vurgulamaktadır. Sonuç olarak, tonsillerden kaynaklanan non-Hodgkin lenfomalar, özellikle baş ve boyun bölgesinde, spesifik olmayan semptomlarla kendini gösterebilir ve tanı gecikmelerine yol açabilir. Erken tanı, biyopsi ve multidisipliner bir yaklaşım, zamanında ve etkili tedavi için hayati öneme sahiptir. Bu rapor, tonsillerdeki DLBCL olgularında klinik dikkat ve uygun tanısal stratejilerin gerekliliğini ortaya koymaktadır.

🔖

Cite This Article

Güzel, Ö. F., Yavuz, F. (2026). Rarely Observed Tonsil Diffuse Large B-Cell Lymphoma: A Case Report of 63-Year-Old Male Patient. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 1. https://doi.org/10.47572/muskutd.1768187

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Storck K, Brandstetter M, Keller U, et al. Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 2019;15(1):1.
  2. Chi HS, Lee KW, Chiang FY, et al. Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. Kaohsiung J Med Sci. 2012;28(8):435-441.
  3. Silva TD, Ferreira CB, Leite GB, et al. Oral manifestations of lymphoma: a systematic review. Ecancermedicalscience. 2016;10:665.
  4. Marie E, Navallas M, Katz DS, et al. Non-Hodgkin lymphoma imaging spectrum in children, adolescents, and young adults. Radiographics. 2022;42(4):1214-1238.
  5. Lai YR, Chang YL, Lee CH, et al. Risk of non-Hodgkin lymphoma among patients with hepatitis B virus and hepatitis C virus in Taiwan: a nationwide cohort study. Cancers (Basel). 2022;14(3):583.
  6. Wang Q, De Luca A, Smith C, et al. Chronic hepatitis B and C virus infection and risk for non-Hodgkin lymphoma in HIV-infected patients: a cohort study. Ann Intern Med. 2017;166(1):9-17.
  7. Deng D, Wang Y, Liu W, et al. Oral and maxillofacial non-Hodgkin lymphomas: case report with review of literature. Medicine (Baltimore). 2017;96(35):e7890.
  8. Tuşaliu M, Mogoantă CA, Dobrea CM, et al. Clinical and histological aspects with therapeutic implications in head and neck lymphomas. Rom J Morphol Embryol. 2015;56(2):499-504.
  9. Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059-3068.
  10. Pfreundschuh M, Trümper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006;7(5):379-391.