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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 1

Relationship Between Serum Vitamin D Levels and Clinical Findings: What We Know and Unknown in Pediatric Cases

Serum D Vitamini Düzeyleri ile Klinik Bulgular Arasındaki İlişki: Pediatrik Olgularda Bildiklerimiz ve Bilmediklerimiz

Bünyamin Güney(MSKÜ Tıp Fakültesi Radyoloji AD)0000-0002-0853-4184
Gürbüz Akçay(PAMUKKALE UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-4682-9258
Pages
—
Publication Date
2026-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Vitamin D plays a crucial role in calcium homeostasis, influencing bone health and overall well-being.

📌 3 Key Takeaways

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Objective & Hypothesis:Vitamin D plays a crucial role in calcium homeostasis, influencing bone health and overall well-being.
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Key Findings & Data:Electronic medical records of 396 children (aged 3.5 days to 17.6 years) from the pediatric clinic of a private hospital were analyzed.
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Conclusion & Impact:Understanding these associations is essential for timely intervention and emphasizes the importance of assessing vitamin D status in children presenting with RRIs, night sweats, rib flare, and genu varum.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Night Sweats · Recurrent Respiratory Infections · Rib Flare

Abstract

Vitamin D plays a crucial role in calcium homeostasis, influencing bone health and overall well-being. Despite universal supplementation recommendations, vitamin D deficiency remains highly prevalent, particularly among pediatric populations. This study investigates the symptoms and clinical findings associated with vitamin D levels in children, focusing on recurrent respiratory infections (RRIs), night sweats, rib flare, and genu varum. Electronic medical records of 396 children (aged 3.5 days to 17.6 years) from the pediatric clinic of a private hospital were analyzed. Serum levels of vitamin D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase were evaluated, and symptomatic cases underwent further assessment. Among the patients, 76.26% exhibited low vitamin D levels. Symptoms such as night sweats and RRIs were correlated with vitamin D insufficiency and deficiency (80.28% and 80.87%, respectively). Specific clinical findings, including rib flare (75.12%) and genu varum (78.26%), were also associated with low vitamin D levels. The study revealed weak positive correlations between vitamin D levels and both calcium (r=0.287, p<0.001) and phosphorus levels (r=0.211, p<0.001), a weak negative correlation with parathyroid hormone levels (r=−0.219, p<0.001), and no significant correlation with alkaline phosphatase levels (r=0.083, p=0.100). This study highlights a significant association between low vitamin D levels and specific symptoms and clinical findings in pediatric patients. Understanding these associations is essential for timely intervention and emphasizes the importance of assessing vitamin D status in children presenting with RRIs, night sweats, rib flare, and genu varum.

Özet

D vitamini, kalsiyum homeostazında önemli bir rol oynar ve hem kemik sağlığını hem de genel refahı etkiler. Evrensel takviye önerilerine rağmen, D vitamini eksikliği özellikle pediatrik popülasyonlarda yaygınlığını korumaktadır. Bu çalışma, çocuklarda D vitamini düzeyleriyle ilişkili semptom ve klinik bulguları araştırmakta, özellikle tekrarlayan solunum yolu enfeksiyonları, gece terlemeleri, arcus costalis belirginliği ve genu varuma odaklanmaktadır. Özel bir hastanenin çocuk kliniğinden 396 çocuğun (yaş aralığı: 3,5 gün–17,6 yıl) elektronik kayıtları incelendi. D vitamini, paratiroid hormonu, kalsiyum, fosfor ve alkalen fosfataz düzeyleri değerlendirildi; semptomatik çocuklar ayrıca analiz edildi. Hastaların %76,26’sında düşük D vitamini düzeyleri saptandı. Gece terlemeleri ve tekrarlayan solunum yolu enfeksiyonları gibi semptomlar, sırasıyla %80,28 ve %80,87 oranında D vitamini yetersizliği veya eksikliği ile ilişkiliydi. Arcus costalis belirginliği (%75,12) ve genu varum (%78,26) gibi klinik bulgular da düşük D vitamini düzeyleriyle ilişkilendirildi. D vitamini düzeylerinin kalsiyum (r=0,287, p<0,001) ve fosfor (r=0,211, p<0,001) düzeyleriyle zayıf pozitif, paratiroid hormonu ile zayıf negatif korelasyon gösterdiği; alkalen fosfataz düzeyleriyle ise anlamlı bir ilişki bulunmadığı saptandı (r=0,083, p=0,100). Bu çalışma, pediatrik hastalarda düşük D vitamini düzeyleri ile belirli semptom ve klinik bulgular arasındaki önemli ilişkiyi ortaya koymakta ve tekrarlayan solunum yolu enfeksiyonları, gece terlemeleri, arcus costalis belirginliği ve genu varum ile başvuran çocuklarda D vitamini durumunun değerlendirilmesinin önemine dikkat çekmektedir.

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Cite This Article

Güney, B., Akçay, G. (2026). Relationship Between Serum Vitamin D Levels and Clinical Findings: What We Know and Unknown in Pediatric Cases. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 1. https://doi.org/10.47572/muskutd.1705748

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