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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 1

The Correlation Between Interictal EEG and Prognosis in Epileptic Patients

Epileptik Hastalarda İnteriktal EEG ile Prognoz Arasındaki İlişki

Arif Tolga Sönmez(Etlik Şehir Hastanesi)0000-0003-3621-0141
Yasemin Biçer Gömceli(USKUDAR UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5043-0891
Gülnihal Kutlu(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0002-9325-4151
Pages
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Publication Date
2026-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In Group 2 (<1 seizure/month), seizure counts assessed at the 6th and 12th months also decreased significantly. iiEEG improvements were significant at the 1st, 3rd, and 6th months in the overall cohort, and differences at the 9th and 12th months favored Group 1.

📌 3 Key Takeaways

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Objective & Hypothesis:Epilepsy is a clinical condition characterized by increased excitability of cortical neurons in the brain.
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Key Findings & Data:Patients were monitored with serial EEG recordings at 1, 3, 6, 9, and 12 months and classified into two groups based on seizure frequency.
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Conclusion & Impact:In Group 2 (<1 seizure/month), seizure counts assessed at the 6th and 12th months also decreased significantly. iiEEG improvements were significant at the 1st, 3rd, and 6th months in the overall cohort, and differences at the 9th and 12th months favored Group 1.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:EEG Monitoring · Interictal EEG · Neurophysiology

Abstract

Epilepsy is a clinical condition characterized by increased excitability of cortical neurons in the brain. Electroencephalogram (EEG) detects the brain’s electrical activity and can reveal epileptogenic electrical foci. This study evaluated the relationship between interictal EEG (iiEEG) abnormalities and prognosis in newly diagnosed epilepsy patients with abnormal initial iiEEG. Patients were monitored with serial EEG recordings at 1, 3, 6, 9, and 12 months and classified into two groups based on seizure frequency. Group 1 (≥1 seizure/month) showed significant improvement in both seizure frequency and iiEEG findings over time. In Group 2 (<1 seizure/month), seizure counts assessed at the 6th and 12th months also decreased significantly. iiEEG improvements were significant at the 1st, 3rd, and 6th months in the overall cohort, and differences at the 9th and 12th months favored Group 1. These results suggest that the prognostic value of iiEEG varies according to baseline seizure frequency and may be particularly informative in patients with higher seizure burden.

Özet

Epilepsi, beyindeki kortikal nöronların artmış uyarılabilirliği ile karakterize edilen klinik bir durumdur. Elektroensefalogram (EEG), beynin elektriksel aktivitesini kaydeder ve epileptojenik odakları ortaya çıkarabilir. Bu çalışma, başlangıç interiktal EEG’si (iiEEG) anormal olan yeni tanı epilepsi hastalarında iiEEG anormallikleri ile prognoz arasındaki ilişkiyi değerlendirmiştir. Hastalar 1., 3., 6., 9. ve 12. aylarda seri EEG kayıtlarıyla izlenmiş ve nöbet sıklıklarına göre iki gruba ayrılmıştır. Grup 1’de (≥1 nöbet/ay) zaman içinde hem nöbet sıklığında hem de iiEEG bulgularında anlamlı düzelme gözlenmiştir. Grup 2’de (<1 nöbet/ay) ise 6. ve 12. aylarda değerlendirilen toplam nöbet sayılarında anlamlı azalma saptanmıştır. Tüm kohortta iiEEG bulgularındaki düzelme 1., 3. ve 6. aylarda anlamlı bulunmuş; 9. ve 12. aylardaki iiEEG değişiklikleri ise Grup 1 lehine belirgin farklılık göstermiştir. Bu sonuçlar, iiEEG’nin prognostik değerinin tanı anındaki nöbet sıklığına göre değiştiğini ve özellikle yüksek nöbet yükü olan hastalarda daha anlamlı bilgiler sağlayabileceğini düşündürmektedir.

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Cite This Article

Sönmez, A. T., Gömceli, Y. B., Kutlu, G. (2026). The Correlation Between Interictal EEG and Prognosis in Epileptic Patients. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 1. https://doi.org/10.47572/muskutd.1655753

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