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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 2

The Impact of Statin Use on the Outcomes of Platelet-Rich Plasma (PRP) Therapy in Patients with Early (I–II) Stage Knee Osteoarthritis

Statin Kullanımının Erken(I-II) Evre Diz Osteoartriti olan Hastalarda Uygulanan PRP Tedavisinin Sonuçlarına Etkisi

Mustafa Cem Özkan0009-0001-2847-1854
Oğuzhan Erciyes(Marmaris Devlet Hastanesi)0000-0001-7146-2382
Taner Bertan(Çaldıran Devlet Hastanesi)0009-0000-5736-1366
Umut Canbek(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0003-1741-7059
Ulaş Akgün(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0002-5298-6559
Fatih İlker Can(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0001-5880-5336
Emre Gültaç(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0003-1943-2199
Nevres Aydoğan(MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE)0000-0002-1837-2676
Pages
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Publication Date
2026-08-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Regardless of statin use, PRP treatment was found to improve patients’ clinical and functional scores.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:There are studies indicating that both statins and Platelet-Rich Plasma (PRP) have effects on inflammation and the arthritis process.
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Key Findings & Data:Between January 2018 and August 2020, the medical records of all patients who underwent PRP treatment for stage I–II knee osteoarthritis were retrospectively reviewed.
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Conclusion & Impact:Regardless of statin use, PRP treatment was found to improve patients’ clinical and functional scores.
🔬Design:Review & Systematic Survey
📍Scope:2018 Verileri
⚙️Variables:Early stage knee osteoarthritis · Gonarthrosis · PRP

Abstract

There are studies indicating that both statins and Platelet-Rich Plasma (PRP) have effects on inflammation and the arthritis process. The aim of our study was to investigate the effect of statin use on the clinical and functional outcomes of PRP treatment in patients with early-stage knee osteoarthritis. Between January 2018 and August 2020, the medical records of all patients who underwent PRP treatment for stage I–II knee osteoarthritis were retrospectively reviewed. Patients who did not use statins and received PRP treatment for knee osteoarthritis were designated as Group 1, while patients who used statins for hypercholesterolemia and received PRP treatment for knee osteoarthritis were designated as Group 2. Patient demographics, radiological images, and clinical records were retrospectively analyzed. The clinical and functional effects of PRP treatment were compared between the two groups. A total of 70 patients aged 40–70 years with stage I–II knee osteoarthritis were included in the study. In the EQ5D5L quality of life scale, a statistically significant difference was observed between the two groups before PRP treatment (p = 0.036). No statistically significant difference was observed in any other parameters examined. Our study investigated whether statin use had a positive or negative effect on PRP treatment; no significant difference was found in terms of functional and clinical results. Regardless of statin use, PRP treatment was found to improve patients’ clinical and functional scores.

Özet

Hem Statinlerin hem de PRP’(Plateletten Zengin Plazma) nin inflamasyon ve artrit süreci üzerine etikleri olduğunu gösteren çalışmalar mevcuttur. Çalışmamızın amacı statin kullanımının erken evre diz osteoartriti olan hastalarda uygulanan PRP tedavisinin klinik ve fonksiyonel sonuçları üzerine etkisinin incelenmesidir. Ocak 2018- Ağustos 2020 tarihleri arasında evre I-II diz osteoartriti nedeniyle PRP uygulanan tüm hastaların tıbbi kayıtları retrospektif olarak incelendi. Statin kullanmayan ve diz osteoartrit nedeniyle PRP tedavisi alan hastalar grup 1, hiperkolesterolemi nedeniyle statin kullanırken diz osteoartrit nedeniyle PRP tedavisi alan hastalar grup 2 olarak belirlendi. Hasta dosyaları taranarak hastaların demografik verileri, radyolojik görüntüleri ve klinik kayıtları retrospektif incelendi. İki grup arasında PRP tedavisinin klinik ve fonksiyonel etkisi karşılaştırıldı. Çalışmaya 40-70 yaş aralığında evre I-II diz osteoartriti olan toplam 70 hasta dahil edildi. Diz osteoartriti yaşam kalitesi ölçeği olan EQ5D5L’de PRP tedavisi öncesi iki grup arasında istatistiksel olarak anlamlı farklılık gözlenmiştir (p=0.036). Bunun dışında bakılan tüm parametrelerde anlamlı bir farklılık gözlenmemiştir. Çalışmamızda statin kullanımının PRP tedavisi üzerine pozitif veya negatif etkisi olup olmadığı araştırılmış; fonksiyonel ve klinik sonuçlar açısından anlamlı bir fark bulunmamıştır. Araştırmamızda PRP tedavisinin statin kullanımından bağımsız olarak hastaların klinik ve fonksiyonel değerlerinde artış sağladığı görüldü.

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Cite This Article

Özkan, M. C., Erciyes, O., Bertan, T., Canbek, U., Akgün, U., Can, F. İ., Gültaç, E., Aydoğan, N. (2026). The Impact of Statin Use on the Outcomes of Platelet-Rich Plasma (PRP) Therapy in Patients with Early (I–II) Stage Knee Osteoarthritis. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 2. https://doi.org/10.47572/muskutd.1783740

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