Journals / Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi / 2026 / Cilt: 15 Sayı: 1

Lavender Oil and Genetic Interaction: A Review on Health from an Epigenetic Perspective

Lavanta Yağı ve Genetik Etkileşim: Epigenetik Perspektiften Sağlık Üzerine Bir İnceleme

Ümit Karakaş(BAYBURT ÜNİVERSİTESİ)0000-0001-9321-5876
Pages
69–76
Publication Date
2025-01-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this direction, elucidating the biological mechanisms of lavender oil may make it a more effective tool in treating diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Lavender oil is an essential oil extracted from the lavender plant, an important member of the Lamiaceae family, and is characterized by various therapeutic effects.
📊
Key Findings & Data:Considering the critical role of miRNAs in regulating gene expression, the potential of lavender oil to modulate genetic mechanisms, especially by affecting miRNAs associated with stress, depression, and inflammation, is a significant research area.
💡
Conclusion & Impact:In this direction, elucidating the biological mechanisms of lavender oil may make it a more effective tool in treating diseases.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Lavanta Yağı · Terapötik Etkiler · miRNA

Abstract

Objective: Lavender oil is an essential oil extracted from the lavender plant, an important member of the Lamiaceae family, and is characterized by various therapeutic effects. Historically, it has found a wide range of uses from ancient civilizations to the present day due to its antibacterial, anti-inflammatory, anxiolytic, antifungal, and wound-healing properties. Linalool and linalyl acetate, the main components of lavender oil, have sedative effects on the nervous system, reducing inflammation and oxidative stress, and can help treat various chronic diseases. Studies have shown that lavender oil has a wide spectrum of effects ranging from neurological disorders to cancer. However, how these effects are realized at the molecular level has yet to be fully understood. Method: The content of the study was created by combinations of the keywords ‘lavender oil,’ ‘miRNA,’ ‘epigenetic’, and ‘gene expression’ and searches from PubMed, Google Scholar, Web of Science, and Science Direct databases. Results: In recent years, the effects of essential oils at the genetic and epigenetic levels have been emphasized, and their possible interactions with miRNAs have been examined. Considering the critical role of miRNAs in regulating gene expression, the potential of lavender oil to modulate genetic mechanisms, especially by affecting miRNAs associated with stress, depression, and inflammation, is a significant research area. However, the need for more literature in this field draws attention. A better understanding of the therapeutic effects of lavender oil will be possible with the increase of molecular studies focusing specifically on its effects on miRNAs. Conclusion: Future studies may solidify the place of lavender oil in molecular biology and expand clinical use. In this direction, elucidating the biological mechanisms of lavender oil may make it a more effective tool in treating diseases.

Özet

Amaç: Lavanta yağı, Lamiaceae ailesinin önemli bir üyesi olan lavanta bitkisinden elde edilen ve çeşitli terapötik etkilerle öne çıkan bir uçucu yağdır. Tarihsel olarak, antik medeniyetlerden günümüze kadar antibakteriyel, antienflamatuar, anksiyolitik, antifungal ve yara iyileştirici özellikleri nedeniyle geniş bir kullanım alanı bulmuştur. Lavanta yağının temel bileşenleri olan linalool ve linalil asetat, sinir sistemi üzerinde yatıştırıcı etkiler gösterirken, inflamasyonu ve oksidatif stresi azaltarak çeşitli kronik hastalıkların tedavisine yardımcı olabilmektedir. Yapılan araştırmalar, lavanta yağının nörolojik bozukluklardan kansere kadar uzanan geniş bir etki spektrumu olduğunu ortaya koymuş, ancak bu etkilerin moleküler düzeyde nasıl gerçekleştiği henüz tam olarak anlaşılmamıştır. Çalışmanın amacı güncel literatürü mikroRNA’lar çerçevesinde derlemektir. Yöntem: Çalışmanın içeriği “Lavanta yağı”, “miRNA”, “epigenetik”, “gen ifadesi” anahtar kelimelerinin kombinasyonları ile PubMed, Google akademik, Web of science ve Science direct veri tabanlarından yapılan taramalarla oluşturulmuştur. Bulgular: Son yıllarda, esansiyel yağların genetik ve epigenetik düzeydeki etkileri üzerinde durulmakta ve miRNA'lar ile olası etkileşimleri incelenmektedir. miRNA'ların gen ekspresyonunun düzenlenmesindeki kritik rolü göz önüne alındığında, lavanta yağının özellikle stres, depresyon ve inflamasyonla ilişkili miRNA'ları etkileyerek genetik mekanizmaları modüle etme potansiyeli büyük bir araştırma alanı olarak karşımıza çıkmaktadır. Ancak, bu alandaki literatür eksikliği dikkat çekmektedir. Lavanta yağının terapötik etkilerinin daha iyi anlaşılması, özellikle miRNA'lar üzerindeki etkilerine odaklanan moleküler çalışmaların artmasıyla mümkün olacaktır. Sonuç: Gelecekteki çalışmalar, lavanta yağının moleküler biyolojideki yerini sağlamlaştırabilir ve klinik kullanımı genişletebilir. Bu doğrultuda, lavanta yağının biyolojik mekanizmalarını aydınlatmak, onu hastalıkların tedavisinde daha etkili bir araç haline getirebilir.

🔖

Cite This Article

Karakaş, Ü. (2025). Lavender Oil and Genetic Interaction: A Review on Health from an Epigenetic Perspective. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, Cilt: 15 Sayı: 1, 69–76. https://doi.org/10.31020/mutftd.1587332

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (24)

  1. Salahudin H, et al. Lavender. In: Zia-Ul-Haq M, Abdulkreem AL-Huqail A, Riaz M, Farooq Gohar U, eds. Essentials of Medicinal and Aromatic Crops. Springer International Publishing; 2023;965-982. doi:10.1007/978-3-031-35403-8_37
  2. Hedayati S, et al. Recent developments in the encapsulation of lavender essential oil. Advances in Colloid and Interface Science Published online 2024;103229. doi:https://doi.org/10.1016/j.cis.2024.103229
  3. Parkash V, Singh H. Lavandula angustifolia L.(lavender): An important aromatic medicinal shrub and its in vitro micro-propagation for conservation. Journal of Agricultural Technology 2013;9(3):91-702.
  4. Khan SU, et al. Lavender Plant: Farming and Health Benefits. CMM 2024;24(6):702-711. doi:10.2174/1566524023666230518114027
  5. Nayik GA, Ansari MJ. Essential Oils: Extraction, Characterization and Applications. Academic Press; 2023. Accessed November 14, 2024. https://doi.org/10.1016/B978-0-323-91740-7.00009-8 6. Yenikalaycı A, Bozarı S, Kurt F. Lavanta (Lavandula X intermedia Emeric Ex Loisel) Bitkisinin Gölgede ve Güneşte Kurutulmasının Uçucu Yağ Kalitesi Üzerine Etkisi. DOFEBD 2023;6(1):1-9. doi:10.57244/dfbd.1215782 7. Malloggi E, et al. Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects. Applied Psych Health & Well 2022;14(2):663-690. doi:10.1111/aphw.12310 8. Pokajewicz K, et al. Lavandula x intermedia—a bastard lavender or a plant of many values? Part ii. Biological activities and applications of lavandin. Molecules 2023;28(7):2986. doi:https://doi.org/10.3390/molecules28072986
  6. Erland LAE, Mahmoud SS. Chapter 57 - Lavender (Lavandula angustifolia) Oils. In: Preedy VR, ed. Essential Oils in Food Preservation, Flavor and Safety. Academic Press; 2016;501-508. doi:10.1016/B978-0-12-416641-7.00057-2
  7. Chen L, et al. Beta-Myrcene as a Sedative–Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice. Pharmaceuticals 2024;17(9):1161. doi:https://doi.org/10.3390/ph17091161
  8. Bavarsad NH, et al. Aromatherapy for the brain: Lavender’s healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer’s disease: A review article. Heliyon. Published online 2023. doi:https://doi.org/10.1016/j.heliyon.2023.e18492
  9. Donelli D, et al. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine 2019;65:153099. doi:https://doi.org/10.1016/j.phymed.2019.153099
  10. Duan J, et al. Therapeutic effects and mechanism of action of lavender essential oil on atopic dermatitis by modulating the STAT3/RORγt pathway. Arabian Journal of Chemistry 2024;17(2):105525. doi:https://doi.org/10.1016/j.arabjc.2023.105525
  11. Xie Q, Wang Y, Zou GL. Protective effects of lavender oil on sepsis-induced acute lung injury via regulation of the NF-κB pathway. Pharmaceutical Biology 2022;60(1):968-978. doi:10.1080/13880209.2022.2067570
  12. Prashar A, Locke IC, Evans CS. Cytotoxicity of lavender oil and its major components to human skin cells. Cell Proliferation 2004;37(3):221-229. doi:10.1111/j.1365-2184.2004.00307.x
  13. Shaheen ZK, Al-Ali AA, Al-Asadi SA. Anti-cancer activity of lavender oil and Newcastle disease virus on human glioblastoma: an in vitro study. J Basrah Res(Sci) 2023;49(1):1-12. doi:https://doi.org/10.56714/bjrs.49.1.1
  14. Gezici S. Promising anticancer activity of lavender (Lavandula angustifolia Mill.) essential oil through induction of both apoptosis and necrosis. Annals of Phytomedicine 2018;7(2):38-45. doi:10.21276/ap.2018.7.2.5
  15. Ez Zoubi Y, Bousta D, Farah A. A Phytopharmacological review of a Mediterranean plant: Lavandula stoechas L. Clin Phytosci 2020;6(1):9. doi:10.1186/s40816-019-0142-y
  16. Maitisha G, et al. Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer. Heliyon 2023;9(11). doi:https://doi.org/10.1016/j.heliyon.2023.e21759
  17. Ramsey JT, et al.Lavender products associated with premature thelarche and prepubertal gynecomastia: case reports and endocrine-disrupting chemical activities. The Journal of Clinical Endocrinology & Metabolism 2019;104(11):5393-5405. doi:10.1210/jc.2018-01880
  18. Aoe M, et al. Lavender essential oil and its main constituents inhibit the expression of TNF-α-induced cell adhesion molecules in endothelial cells. Acta Medica Okayama 2017;71(6):493-503. https://ousar.lib.okayama-u.ac.jp/en/55586
  19. Zhao Q, et al. Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review. Journal of ethnopharmacology 2023;301:115829. doi:https://doi.org/10.1016/j.jep.2022.115829
  20. Faridzadeh A, et al. Neuroprotective potential of aromatic herbs: rosemary, sage, and lavender. Frontiers in Neuroscience 2022;16:909833. doi:10.3389/fnins.2022.909833
  21. Goel H, Goel A. MicroRNA and Rare Human Diseases. Genes 2024;15(10):1243. doi:https://doi.org/10.3390/genes15101243
  22. Piletič K, Kunej T. MicroRNA epigenetic signatures in human disease. Archives of toxicology 2016;90(10):2405-2419. doi:https://doi.org/10.1007/s00204-016-1815-7
  23. Seyhan AA. Trials and tribulations of MicroRNA therapeutics. International Journal of Molecular Sciences 2024;25(3):1469. doi:https://doi.org/10.3390/ ijms25031469
  24. Fung TK, et al. Therapeutic effect and mechanisms of essential oils in mood disorders: Interaction between the nervous and respiratory systems. International Journal of Molecular Sciences 2021;22(9):4844. doi:https://doi.org/ 10.3390/ijms22094844