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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 2 Issue: 2

Is Neurogenous Hyperplasia A Cause of Appendiceal Obliteration ? (A retrospective study of 1397 cases)

NÖROJENİK HİPERPLAZİ APPENDİKS OBLİTERASYONU NEDENİ MİDİR ? ( 1397 olgunun retrospektif incelemesi )

Gülden Diniz
Melek Üstün
Gülden Çengel
Mine Tunakan
Pages
—
Publication Date
2001-08-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, andthatmost cases ofso-calledfibrous obliteration actuallyrepresentneurogenicappendicopathy.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: In this study the presence of neural tissue components was investigated in appendectomy specimens with an obliterated appendix.
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Key Findings & Data:Material and method: Retrospective analysis of 1379 consecutive routine appendectomy specimens revealed 66 cases as "obliterated appendix" (an incidence of 4,2%).
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Conclusion & Impact:Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, andthatmost cases ofso-calledfibrous obliteration actuallyrepresentneurogenicappendicopathy.
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:obliterated appendix · fibrous obliteration · neurogenous hyperplasia

Abstract

Aim: In this study the presence of neural tissue components was investigated in appendectomy specimens with an obliterated appendix. Relationship of the neural tissue presence with other appendical lesions such as carcinoid tumors and acute appendicitis was also evaluated. Material and method: Retrospective analysis of 1379 consecutive routine appendectomy specimens revealed 66 cases as "obliterated appendix" (an incidence of 4,2%). Only 38 appropriate cases have been included in this study. Results: By light microscopy, obliteration was located centrally in the appendix without nodule formation. Loose proliferation of spindle cells, usually in a myxoid background, and with entrapped fat tissue was frequently observed. The spindle cells were positive for S-100 protein in 18 of 38 cases (47,3 %). Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, andthatmost cases ofso-calledfibrous obliteration actuallyrepresentneurogenicappendicopathy.

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Cite This Article

Diniz, G., Üstün, M., Çengel, G., Tunakan, M. (2001). Is Neurogenous Hyperplasia A Cause of Appendiceal Obliteration ? (A retrospective study of 1397 cases). Meandros Medical And Dental Journal, Volume: 2 Issue: 2. https://ajindex.com/articles/1291464

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References (14)

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  9. Petras RE, Goldblum JR. Appendix. In: Danjanov I, Linder J ( eds). Anderson's Pathology, 10 ed. Missouri: Mosby- Year Book, 1996: 1728- 40.
  10. Olsen BS, Holck S. Neurogenous hyperplasia leading to appendiceal obliteration: an Ýmmunohistochemical study of 237 cases. Histopathology 1987, 11: 843- 49.
  11. Stanley WM, Cherwitz D, Hagen K, Snover DC. Neuromas of Appendix: A light- Microscopic, Immunohistochemical and Electron- Microscopic Study of 20 Cases. Am J Surg Pathol 1986; 10: 811-15.
  12. Cooper HS. Intestinal Neoplasms. In: Sternberg SS ( ed ). Diagnostic Surgical Pathology, 3 ed. NewYork: LippincottWilliams &Wilkins, 1999: 1413- 67.
  13. Crawwford JM. The Gastrointestinal Tract. In: Cotran RS, Kumar V, Robbins SL (eds).Pathologic Basis Of Disease, 5 ed. Philadelphia: WB Saunders Com, 1994: 755-829.
  14. Ashley DJB. Tumors Of Gastrointestinal HormoneSecreting Cells. In: Ashley DJB (ed). Ewans!' Histological Appearances of Tumors, 4 ed. NewYork: Churchill Livingstone 1990: 333- 53