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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 19 Issue: 3

A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis

Suzan Demir Pektaş(YILDIRIM BEYAZIT ÜNİVERSİTESİ)
Emine Tuğba Alataş(YILDIRIM BEYAZIT UNIVERSITY)
Gürsoy Doğan(MUGLA SITKI KOCMAN UNIVERSITY)
Salim Neşelioğlu(YILDIRIM BEYAZIT UNIVERSITY)
Özcan Erel(YILDIRIM BEYAZIT UNIVERSITY)
Pages
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Publication Date
2018-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This finding may be responsible for diffuse destruction of hair follicle in the pathogenesis of AA.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress.
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Key Findings & Data:Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder.
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Conclusion & Impact:This finding may be responsible for diffuse destruction of hair follicle in the pathogenesis of AA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Alopecia areata · oxidative stress · thioldisulphide homeostasis

Abstract

Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder. The control and study groups were compared with respect to native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios. The relationships between demographic and lesion characteristics, native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were studied. Results: The mean age of AA patients was 37.5 years. Fifty-eight (58%) patients were male, and the median body mass index was 24 kg/m2. Median age was significantly higher in the AA group (p 0.05). Conclusion: The thiol/disulphide homeostasis shifted towards oxidative stress, and a decrease in thiols and an increase in disulphides were found in the AA patients. This finding may be responsible for diffuse destruction of hair follicle in the pathogenesis of AA.

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Cite This Article

Pektaş, S. D., Alataş, E. T., Doğan, G., Neşelioğlu, S., Erel, Ö. (2018). A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis. Meandros Medical And Dental Journal, Volume: 19 Issue: 3. https://doi.org/10.4274/meandros.48303

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