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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 24 Issue: 1

Evaluation of Cytotoxicity and Antibacterial Effect of Different Types of Mineral Trioxide Aggregate

Özge Ünlü(ISTANBUL ATLAS UNIVERSITY)
Edibe Egil(ISTANBUL AYDIN UNIVERSITY)
Mehmet Derici(KIRKLARELI UNIVERSITY)
Seda Kuşoğlu(USKUDAR UNIVERSITY)
Pages
—
Publication Date
2023-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to our study, NeoMTA and RetroMTA may be recommended for clinical applications in comparison with the conventional AngelusMTA.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Mineral trioxide aggregate (MTA) has been used as a filling material in endodontic procedures over decades.
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Key Findings & Data:Materials and Methods: Cytotoxicity assay was performed on 3T3 fibroblast cell lines were determined using yellow tetrazolium 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, while the antimicrobial activity was tested with the broth microdilution method.
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Conclusion & Impact:Conclusion: According to our study, NeoMTA and RetroMTA may be recommended for clinical applications in comparison with the conventional AngelusMTA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mineral trioxide aggregate · MTA · cytotoxicity

Abstract

Objective: Mineral trioxide aggregate (MTA) has been used as a filling material in endodontic procedures over decades. The newer formulations of MTA were launched in the dental market and their cytotoxic, proliferative and antimicrobial effects need to be revealed. This study compared the possible cytotoxic and proliferative effects on fibroblasts and the antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, and Enterococcus faecalis of four different MTAs in the dental market. Materials and Methods: Cytotoxicity assay was performed on 3T3 fibroblast cell lines were determined using yellow tetrazolium 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, while the antimicrobial activity was tested with the broth microdilution method. Results: RetroMTA, AngelusMTA, and NeoMTA demonstrated a proliferative effect on 3T3 cells, suggesting induction in tissue repair. Moreover, NeoMTA showed the highest antimicrobial activity against all strains tested. Conclusion: According to our study, NeoMTA and RetroMTA may be recommended for clinical applications in comparison with the conventional AngelusMTA.

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Cite This Article

Ünlü, Ö., Egil, E., Derici, M., Kuşoğlu, S. (2023). Evaluation of Cytotoxicity and Antibacterial Effect of Different Types of Mineral Trioxide Aggregate. Meandros Medical And Dental Journal, Volume: 24 Issue: 1. https://doi.org/10.4274/meandros.galenos.2021.54036

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