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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 26 Issue: 1

Comparison of chromosome analysis, factor V Leiden, and prothrombin G20210A mutation results according to the number of pregnancy losses in recurrent pregnancy loss

Tekrarlayan gebelik kayıplarında gebelik kaybı sayısına göre kromozom analizi, faktör V Leiden ve protrombin G20210A mutasyon sonuçlarının karşılaştırılması

Hande Özkalaycı(Bolu Abant Izzet Baysal Training And Research Hospital)0000-0002-8520-623X
Mehmet Kocabey(Hatay Training And Research Hospital)0000-0001-9565-6907
Pages
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Publication Date
2025-03-20
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Due to the limited number of patients, a meta-analysis of this result with other case series in Turkey would be beneficial.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Recurrent pregnancy loss is defined as the loss of two or more pregnancies in some sources, or three or more in others, before 20-24 weeks of gestation.
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Key Findings & Data:We aimed to reveal the frequency of parental chromosome abnormalities, Prothrombin G20210A mutations (PGM), and Factor V Leiden (FVL) in couples presenting with recurrent pregnancy losses and to test whether there is a significant difference between two and more than two pregnancy losses.
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Conclusion & Impact:Due to the limited number of patients, a meta-analysis of this result with other case series in Turkey would be beneficial.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Thrombophilia · Recurrent pregnancy loss · Prothrombin

Abstract

Objective: Recurrent pregnancy loss is defined as the loss of two or more pregnancies in some sources, or three or more in others, before 20-24 weeks of gestation. The causes being investigated include parental chromosomal abnormalities and hereditary thrombophilia. We aimed to reveal the frequency of parental chromosome abnormalities, Prothrombin G20210A mutations (PGM), and Factor V Leiden (FVL) in couples presenting with recurrent pregnancy losses and to test whether there is a significant difference between two and more than two pregnancy losses. Materials and Methods: A total of 171 couples who presented to the Medical Genetics outpatient clinics of two tertiary hospitals located in Bolu and Hatay provinces due to a history of recurrent pregnancy loss were evaluated. Demographic data, medical and family history, chromosomal analysis results of the couples, and FVL and PGM results of the women were recorded. Results: We detected chromosomal abnormalities in 2.9% of those evaluated. Factor V Leiden frequency was found to be 11.5% and PGM frequency was 3%. No statistically significant distinction was obtained between the groups, categorized as those with two and more than two pregnancy losses, in terms of the occurrence of chromosomal abnormalities (p=0.65), FVL (p=0.58), and PGM (p=0.65). Conclusion: A similar approach to requesting a test can be taken for both patient groups. Due to the limited number of patients, a meta-analysis of this result with other case series in Turkey would be beneficial.

Özet

Amaç: Tekrarlayan gebelik kaybı, bazı kaynaklarda iki veya daha fazla, bazılarında ise üç veya daha fazla gebeliğin 20-24. gebelik haftasından önce kaybedilmesi olarak tanımlanmaktadır. Araştırılan nedenler arasında ebeveyn kromozom anormallikleri ve kalıtsal trombofili yer almaktadır. Tekrarlayan gebelik kayıpları ile başvuran çiftlerde ebeveyn kromozom anormallikleri, Protrombin G20210A mutasyonları (PGM) ve Faktör V Leiden (FVL) sıklığını ortaya koymayı, iki ve ikiden fazla gebelik kayıpları arasında anlamlı bir fark olup olmadığını test etmeyi amaçladık. Gereç ve Yöntem: Bolu ve Hatay illerinde bulunan iki üçüncü basamak hastanenin Tıbbi Genetik polikliniklerine tekrarlayan gebelik kaybı öyküsü nedeniyle başvuran toplam 171 çift değerlendirildi. Çiftlerin demografik verileri, tıbbi ve soygeçmişleri, kromozomal analiz sonuçları, kadınların FVL ve PGM sonuçları kaydedildi. Bulgular: Değerlendirilenlerin %2,9'unda kromozomal anormallikler tespit ettik. Faktör V Leiden frekansı %11,5, PGM frekansı ise %3 olarak bulundu. İki ve ikiden fazla gebelik kaybı yaşayan gruplar arasında kromozomal anormallikler (p=0,65), FVL (p=0,58) ve PGM (p=0,65) görülme sıklığı açısından istatistiksel olarak anlamlı bir farklılık elde edilmedi. Sonuç: Her iki hasta grubu için de test isteme konusunda benzer bir yaklaşım izlenebilir. Hasta sayısının sınırlı olması nedeniyle, bu sonucun Türkiye'deki diğer vaka serileriyle meta-analizinin yapılması faydalı olacaktır.

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Cite This Article

Özkalaycı, H., Kocabey, M. (2025). Comparison of chromosome analysis, factor V Leiden, and prothrombin G20210A mutation results according to the number of pregnancy losses in recurrent pregnancy loss. Meandros Medical And Dental Journal, Volume: 26 Issue: 1. https://doi.org/10.69601/meandrosmdj.1570237

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