SavedAdd your journal

Journals / Marmara Medical Journal / 2026 / Volume: 16 Issue: 3

HYPERIMMUNOGLOBUUN E SYNDROME (JOB'S SYNDROME) IN A-22-MONTH OLD GIRL AND IVIG TREATMENT

Sibel Aka
Sami Yazar
Ömer Ceran
Pages
—
Publication Date
2016-12-03
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Key Words: Hyperimmunoglobulin E syndrome, Job’s syndrome

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hyperimmunoglobulin E syndrome is a rare disorder characterized by pruritic dermatitis, recurrent staphylococcal skin abscesses and extremely elevated concentrations of immunoglobulin E in serum.
📊
Key Findings & Data:We report a patient who has pruritic vesiculopapules, recurrent episodes of skin abscesses on the scalp and face, and respiratory problems from the age of ten days (severe cough, wheezing, acute otitis media, pneumonia).
💡
Conclusion & Impact:Key Words: Hyperimmunoglobulin E syndrome, Job’s syndrome
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hyperimmunoglobulin E syndrome is a rare disorder characterized by pruritic dermatitis, recurrent staphylococcal skin abscesses and extremely elevated concentrations of immunoglobulin E in serum. We report a patient who has pruritic vesiculopapules, recurrent episodes of skin abscesses on the scalp and face, and respiratory problems from the age of ten days (severe cough, wheezing, acute otitis media, pneumonia). She was diagnosed as Hyper-lgE syndrome and treated with IVIG along with antibiotics. Key Words: Hyperimmunoglobulin E syndrome, Job’s syndrome

Özet

Hyperimmunoglobulin E syndrome is a rare disorder characterized by pruritic dermatitis, recurrent staphylococcal skin abscesses and extremely elevated concentrations of immunoglobulin E in serum. We report a patient who has pruritic vesiculopapules, recurrent episodes of skin abscesses on the scalp and face, and respiratory problems from the age of ten days (severe cough, wheezing, acute otitis media, pneumonia). She was diagnosed as Hyper-lgE syndrome and treated with IVIG along with antibiotics. Key Words: Hyperimmunoglobulin E syndrome, Job’s syndrome

🔖

Cite This Article

Aka, S., Yazar, S., Ceran, Ö. (2016). HYPERIMMUNOGLOBUUN E SYNDROME (JOB'S SYNDROME) IN A-22-MONTH OLD GIRL AND IVIG TREATMENT. Marmara Medical Journal, Volume: 16 Issue: 3. https://ajindex.com/articles/1287231

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Chamlin SL, McCalmont TH, Cunningham BB, et al. Cutaneous manifestations of hyper-lgE syndrome in infants and children. J Fediatr 2002;141:572-575.
  2. Davis SD, Schaller S, Wedgewood FU. Job's syndrome: Recurrent 'Cold staphylococcal abscesses. Lancet 1996;i: 1013-1015.
  3. Buckley RM, Wray BB, Belmaker E. Extreme hyperimmunoglobulin E and undue susceptibility to infection. Pediatrics 1972;49:59-70.
  4. Donabedian H, Oallin Jl. The hyperimmunoglobulin E syndrome, recurrent infection (Job's) syndrome: A review of the HIM experience and the literature. Medicine 1983;62:195-208.
  5. Moneret-Vautrin DA, Kanny G, Thinus G. Myperimmunoglobulin E syndrome with recurrent infections (Job's syndrome). Rev Med Intern 1999;20:133-140.
  6. Shirafuji Y, Matsuura H, Sato A, et al. Myperimmunoglobulin E syndrome: a sign of TM1/TM2 imbalance? Eur J Dermatol 1999;9: 129-131.
  7. Grimbacher B, Holland SM, Gallin Jl, et al. Hyper-lg E syndrome with recurrent infections—an autosomal dominant multisystem disorder. M Engl J Med 1999; 340:692-702.
  8. Pherwani AV, Madnani MA.
  9. Hyperimmunoglobulin E syndrome. Indian Pediatrics 2001;38:1029-1034.
  10. Buckley RH. Immunodeficiency with
  11. thrombocytopenia and eczama (Wiskott- Aldrich Syndrome). In: Behrman RE, Kliegman RM, Arvin AM, eds. Melson Textbook of Pediatrics, 15th. ed. USA: W.B. Saunders
  12. Company, 1996:576.
  13. Waldfahrer F, Pah! S, Federspil PA, Iro H. Hyper-lg E syndrome with EMT manifestations. Overview and case report of successful therapy with high dosage i.v. immunoglobulin. HMO 1999;47:1063-1068.
  14. Bilora E, Petrobelli F, Boccioletti V, Pomerri E. Moderate-dose intravenous immunoglobulin treatment of Job's syndrome. A case report. Minerva Med 2000;91:113-1 16.
  15. Gennery AR, Flood TJ, Abinun M, Cant AJ. Bone marrow transplantation does not correct the hyper-lg E syndrome. Bone