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Journals / Marmara Medical Journal / 2024 / Volume: 37 Issue: 3

Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome

Mehmet Altunova(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0001-5351-5022
Recep Gülmez(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0002-9956-8338
Hicaz Zincirkiran Ağuş(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0002-5882-0525
Tugba Aktemur(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0002-5578-432X
Serpil Öztürk(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0002-1967-6401
Ali Evsen(DICLE UNIVERSITY)0000-0002-3780-7137
Yusuf Demir(Cigli Training and Research Hospital)0000-0001-9167-493X
Uğur Köktürk(BULENT ECEVIT UNIVERSITY)0000-0003-0459-9295
Mehmet Köseoğlu(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0002-5138-6367
Gamze Babur Güler(Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital)0000-0003-1207-8692
Pages
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Publication Date
2024-10-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Careful management of this group may reduce morbidity and mortality.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Infective endocarditis (IE) is a severe condition characterized by high mortality rates.
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Key Findings & Data:We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up.
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Conclusion & Impact:Careful management of this group may reduce morbidity and mortality.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Infective endocarditis · Reinfection · Long-term mortality

Abstract

Objective: Infective endocarditis (IE) is a severe condition characterized by high mortality rates. We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up. Patients and Methods: We retrospectively analyzed 204 patients meeting modified Duke criteria for definite IE between 2009 and 2019. Early reinfection was defined as occurrence within 6 months, and late reinfection was defined as occurrence 6 months after the initial diagnosis. Results: Mean follow-up duration was 40.3 ± 26.4 months. Valve surgery was performed in 125 patients (69.8%), while 54 (30.2%) received medical therapy alone. Early reinfection was seen in 9 patients (5.1%), and late reinfection in 12 patients (6.7%). Staphylococci (41.9%), Streptococci (26.3%), and Enterococci (15.6%) were common pathogens. Peripheral limb emboli predicted reinfection (HR 4.118, 95% CI 1.471-11.528, p=0.007). Survival rates at 1, 2, and 5 years were 70.2%, 65.7%, and 57.3%, respectively. Age (HR 1.030, 95% CI 1.011 – 1.049, p=0.002), peripheral limb emboli (HR 2.994, 95% CI 1.509-5.940, p=0.002), and septic shock (HR 2.357, 95% CI 1.097-5.065, p=0.028) predicted mortality. Conclusion: Infective endocarditis mortality rates remain high regardless of reinfection. Peripheral limb emboli independently determine reinfection and mortality. Careful management of this group may reduce morbidity and mortality.

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Cite This Article

Altunova, M., Gülmez, R., Ağuş, H. Z., Aktemur, T., Öztürk, S., Evsen, A., Demir, Y., Köktürk, U., Köseoğlu, M., Güler, G. B. (2024). Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome. Marmara Medical Journal, Volume: 37 Issue: 3. https://doi.org/10.5472/marumj.1573453

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