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Journals / Marmara Medical Journal / 2026 / Volume: 38 Issue: 1

Vitamin D3 has antifibrotic effects on rats with epidural fibrosis

Pınar Kuru Bektaşoğlu(Fatih Sultan Mehmet Education and Research Hospital)0000-0001-9889-9955
Jülide Hazneci(Fatih Sultan Mehmet Education and Research Hospital)0000-0003-2763-2748
Adnan Somay(Fatih Sultan Mehmet Education and Research Hospital)0000-0002-8613-8566
Ali Börekci(Fatih Sultan Mehmet Education and Research Hospital)0000-0002-3687-7934
Bora Gürer(ISTINYE UNIVERSITY)0000-0003-1500-6184
Pages
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Publication Date
2025-01-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: One unfavorable outcome of spinal operations is epidural fibrosis.
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Key Findings & Data:In this study, using a rat laminectomy model, we sought to examine any potential antifibrotic benefits of vitamin D3.
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Conclusion & Impact:Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Epidural fibrosis · Laminectomy · Vitamin D3

Abstract

Objective: One unfavorable outcome of spinal operations is epidural fibrosis. Recurrent back pain and radiculopathy could negatively impact the patient’s quality of life. In this study, using a rat laminectomy model, we sought to examine any potential antifibrotic benefits of vitamin D3. Patients and Methods: Control, local, and systemic vitamin D3 groups (n = 6 rats per group) were randomly assigned. Laminectomy alone was carried out in the control group. Vitamin D3 application onto the dura was done in the local D3 group. Intraperitoneal delivery of the systemic vitamin D3 was carried out in the systemic vitamin D3 group. Epidural fibrosis was studied macroscopically and histopathologically four weeks later. Results: The macroscopic epidural fibrosis score was lower in the local and systemic vitamin D3 groups compared to the control group (p<0.001, for both groups). Comparing the local and systemic vitamin D3 groups to the control group, fibrosis thickness was significantly decreased (p<0.01, for both groups). Conclusion: Vitamin D3 could be an alternative treatment for preventing spinal epidural fibrosis.

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Cite This Article

Bektaşoğlu, P. K., Hazneci, J., Somay, A., Börekci, A., Gürer, B. (2025). Vitamin D3 has antifibrotic effects on rats with epidural fibrosis. Marmara Medical Journal, Volume: 38 Issue: 1. https://doi.org/10.5472/marumj.1629001

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