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Journals / Marmara Medical Journal / 2025 / Volume: 38 Issue: 3

Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004 Study

Selnur Özkurt(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-0702-2830
Bedriye Doğan(İnönü University)0000-0002-8726-3801
Nagehan Özyılmaz(Samsun University)0000-0002-8453-0089
Aslı Aykaç(Near East University)0000-0002-4885-5070
Büşra Ertaş(Marmara University)0000-0001-8374-1098
Ali Şen(Marmara University)0000-0002-2144-5741
Cemile Ceylan(Yeditepe University)0000-0001-6423-8956
Feriha Ercan(Marmara University)0000-0003-2339-5669
Beste Atasoy(Marmara University)0000-0003-1320-9105
Pages
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Publication Date
2025-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model.
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Key Findings & Data:Materials and Methods: Female rats (n=30) were divided into four groups.
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Conclusion & Impact:Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Bladder · Kidney · Myrtus communis

Abstract

Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days. Ionizing radiation (IR) groups were organized as follows: “IR group (IR)” (n=8) received oral SF for four days starting on the day of administration; “MC treatment group (MC-tx)” (n=8) received oral MC for four days beginning on the day of irradiation; and “MC pretreatment group (MC-Ptx)” (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC was administered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats were sacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting to assess mitochondrial apoptosis. Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower in the MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01). Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic and therapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.

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Cite This Article

Özkurt, S., Doğan, B., Özyılmaz, N., Aykaç, A., Ertaş, B., Şen, A., Ceylan, C., Ercan, F., Atasoy, B. (2025). Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004 Study. Marmara Medical Journal, Volume: 38 Issue: 3. https://ajindex.com/articles/1286358

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