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Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 8 Sayı: 2

Antimicrobial Investigation and Synthesis of Novel 1H-Pyrazole-4- (5H)-yl Diazene Derivatives

Yeni 1H-Pirazol-4-(5H)-il Diazen Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin İncelenmesi

Havva Kurt0000-0002-2951-1934
Adnan Çetin0000-0001-6487-9489
Sedat Bozarı0000-0001-5265-2236
Pages
223–229
Publication Date
2018-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

None of the doses showed any antibacterial activity compared to the control.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, firstly, ethyl 1-(4-bromophenyl)-2-(1,3,5-triphenyl-1H-pyrazol-4-(5H)-ylidene) hydrazine (1), which has starting material, was synthesized.
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Key Findings & Data:A series of new 1H-pyrazol-4-yl diazene (2a-h) derivatives were synthesized from reaction the obtained starting material and various hydrazines.
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Conclusion & Impact:None of the doses showed any antibacterial activity compared to the control.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Antimikrobiyal · hidrazin · hidrazon

Abstract

In this study, firstly, ethyl 1-(4-bromophenyl)-2-(1,3,5-triphenyl-1H-pyrazol-4-(5H)-ylidene) hydrazine (1), which has starting material, was synthesized. A series of new 1H-pyrazol-4-yl diazene (2a-h) derivatives were synthesized from reaction the obtained starting material and various hydrazines. The synthesized compounds were confirmed by spectral methods such as elemental analysis, IR and NMR. Antibacterial activity of the compounds were investigated by disc diffusion method against to Gram (+) and Gram (-) bacteria. Gentamicin and Cefotaxime antibiotics were used as the control group. None of the doses showed any antibacterial activity compared to the control.

Özet

Bu çalışmada, ilk olarak başlangıç maddesi olan etil 1-(4-bromofenil)-2-(1,3,5-trifenil-1H-pirazol-4-(5H)-

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Cite This Article

Kurt, H., Çetin, A., Bozarı, S. (2018). Antimicrobial Investigation and Synthesis of Novel 1H-Pyrazole-4- (5H)-yl Diazene Derivatives. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 8 Sayı: 2, 223–229. https://doi.org/10.21597/jist.428383

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