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Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 16 Sayı: 1

Synthesis, Characterization and Carbonic Anhydrase Inhibitor Properties of Metal Complexes of 4-sulfamoylbenzoic Acid

Tevfik Emre Kaya(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0009-0001-9717-5784
Nagihan Kaya(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0009-0001-0146-4961
Şüheda Özkul(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0000-0002-2638-3922
Burak Yildiz(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0000-0002-0869-1091
Ekrem Tunca(DUMLUPINAR ÜNİVERSİTESİ)0000-0001-7556-8379
Halil İlkimen(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0000-0003-1747-159X
Pages
221–232
Publication Date
2026-03-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was determined that complex 6 was 2200 times more selective for hCA I, while complex 4 was 8 times more selective for hCA II.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Six new complexes of 4-sulfamoylbenzoic acid (Hsba) {[Mg(sba)2].2H2O (1), [M(sba)2(H2O)x].yH2O, M = Mn2+, x = 4, y = 2 (2); M = Fe2+ (3), Co2+ (4), x = 4, y = 0; M = Ni2+ (5), Cu2+ (6), x = 2, y = 0} have been prepared.
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Key Findings & Data:The structures of the metal complexes (1-6) have been proposed based on data obtained from analytic and spectroscopic studies.
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Conclusion & Impact:It was determined that complex 6 was 2200 times more selective for hCA I, while complex 4 was 8 times more selective for hCA II.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:4-sulfamoylbenzoic acid · Metal complexes · Carbonic anhydrase

Abstract

Six new complexes of 4-sulfamoylbenzoic acid (Hsba) {[Mg(sba)2].2H2O (1), [M(sba)2(H2O)x].yH2O, M = Mn2+, x = 4, y = 2 (2); M = Fe2+ (3), Co2+ (4), x = 4, y = 0; M = Ni2+ (5), Cu2+ (6), x = 2, y = 0} have been prepared. The structures of the metal complexes (1-6) have been proposed based on data obtained from analytic and spectroscopic studies. The structures of the synthesized metal complexes were observed to be linear for 1, octahedral for 2-4, and tetrahedral for 5 and 6. In the next stage of the study, the inhibitory effects of the Mg(Ac)2, FeSO4.7H2O, Mn(Ac)2.4H2O, Co(Ac)2.4H2O, Ni(Ac)2.4H2O, Cu(Ac)2.2H2O, Hsba and synthesized metal complexes (1-6) on hCA I and hCA II isoenzymes were investigated in vitro. In general, the compounds significantly inhibited hCA I and hCA II. It was determined that complex 6 was 2200 times more selective for hCA I, while complex 4 was 8 times more selective for hCA II.

Özet

Six new complexes of 4-sulfamoylbenzoic acid (Hsba) {[Mg(sba)2].2H2O (1), [M(sba)2(H2O)x].yH2O, M = Mn2+, x = 4, y = 2 (2); M = Fe2+ (3), Co2+ (4), x = 4, y = 0; M = Ni2+ (5), Cu2+ (6), x = 2, y = 0} have been prepared. The structures of the metal complexes (1-6) have been proposed based on data obtained from analytic and spectroscopic studies. The structures of the synthesized metal complexes were observed to be linear for 1, octahedral for 2-4, and tetrahedral for 5 and 6. In the next stage of the study, the inhibitory effects of the synthesized metal complexes on hCA I and hCA II isoenzymes were investigated in vitro. In general, the compounds significantly inhibited hCA I and hCA II. It was determined that the 6 complex was 2200 times more selective for hCA I, while the 4 complex was 8 times more selective for hCA II.

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Cite This Article

Kaya, T. E., Kaya, N., Özkul, Ş., Yildiz, B., Tunca, E., İlkimen, H., *, E. T. (2026). Synthesis, Characterization and Carbonic Anhydrase Inhibitor Properties of Metal Complexes of 4-sulfamoylbenzoic Acid. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 16 Sayı: 1, 221–232. https://doi.org/10.21597/jist.1701182

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