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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 35 Issue: 1

Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats

Ayşegül Akbay Yarpuzlu(Ankara University, Faculty of Health Education and Institute of Biotechnology, Department of Health Education, Ankara, TURKEY)
Yeşim Uğur(Hacettepe University, Faculty of Medicine, Department of Histology and Embryology, Ankara, TURKEY)
Ayşegül Nazikoğlu(Hacettepe University, Faculty of Medicine, Department of Histology and Embryology, Ankara, TURKEY)
Esin Asan(Hacettepe University, Faculty of Medicine, Department of Histology and Embryology, Ankara, TURKEY)
İlkay Yildiz(Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, TURKEY)
Pages
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Publication Date
2007-01-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team.
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Key Findings & Data:Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 .
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Conclusion & Impact:Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:AIDS · HIV-RT inhibitor · 2-phenoxymethyl-5-chlorobenzimidazole

Abstract

Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team. Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 . Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

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Cite This Article

Yarpuzlu, A. A., Uğur, Y., Nazikoğlu, A., Asan, E., Yildiz, İ. (2007). Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. Hacettepe Journal of Biology and Chemistry, Volume: 35 Issue: 1. https://ajindex.com/articles/1271179

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References (13)

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