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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 39 Issue: 2

Glucose 6-Phosphate Dehydrogenase Activatory Properties of Some Organic Compounds and Amino Acids

Bazı Organik Bileşikler ve Amino Asitlerin Glukoz 6-Fosfat Dehidrogenaz Aktivatör Özellikleri

Zafer Ömer Özdemir(Yıldız Technical University, Department of Bioengineering, Davutpaşa Campus, İstanbul, Turkey)
Murat Şentürk(Ağrı İbrahim Çeçen University, Faculty of Art and Science, Department of Chemistry, Ağrı, Turkey)
Deniz Ekinci(Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany)
Pages
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Publication Date
2011-04-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For this purpose, initially erythrocyte glucose 6-phosphate dehydrogenase was managed to be purified 812-fold in a yield of 40.6% by using 2’,5’-ADP Sepharose 4B affinity gel. 4’- Methylsulfonyl acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine exhibited activatory effects on the enzyme. % Activity values for these compounds were determined by plotting activity percentage versus [Activator].

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to assess activatory potentials of 4’- Methylsulfonyl - acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine on human erythrocyte glucose 6-phosphate dehydrogenase.
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Key Findings & Data:The aim of this study was to assess activatory potentials of 4’- Methylsulfonyl - acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine on human erythrocyte glucose 6-phosphate dehydrogenase.
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Conclusion & Impact:For this purpose, initially erythrocyte glucose 6-phosphate dehydrogenase was managed to be purified 812-fold in a yield of 40.6% by using 2’,5’-ADP Sepharose 4B affinity gel. 4’- Methylsulfonyl acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine exhibited activatory effects on the enzyme. % Activity values for these compounds were determined by plotting activity percentage versus [Activator].
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:Activator · amino acid · enzyme

Abstract

The aim of this study was to assess activatory potentials of 4’- Methylsulfonyl - acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine on human erythrocyte glucose 6-phosphate dehydrogenase. For this purpose, initially erythrocyte glucose 6-phosphate dehydrogenase was managed to be purified 812-fold in a yield of 40.6% by using 2’,5’-ADP Sepharose 4B affinity gel. 4’- Methylsulfonyl acetophenone, 4- methylsulfonyl phenylacetic acid, tyrosine and phenylalanine exhibited activatory effects on the enzyme. % Activity values for these compounds were determined by plotting activity percentage versus [Activator].

Özet

Bu çalışmanın amacı 4- metilsülfonil -asetofenon, 4- metilsülfonil fenilasetik asit, tirozin ve fenilalaninin insan eritrosit glukoz 6-fosfat dehidrogenaz üzerindeki aktivatör potansiyelini değerlendirmektir. Bu amaçla, öncelikle eritrosit glukoz 6-fosfat dehidrogenaz 2’,5’-ADP Sepharose 4B afinite jeli kullanılarak 812-kat, %40.6 verimle elde edildi. 4- Metilsülfonil fenilasetik asit, tirozin ve fenilalaninin enzim üzerinde aktivatör etkileri gösterdi. Bu bileşikler için % aktivite-[Aktivatör] grafiği kullanılarak % aktivite değerleri belirlendi.

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Cite This Article

Özdemir, Z. Ö., Şentürk, M., Ekinci, D. (2011). Glucose 6-Phosphate Dehydrogenase Activatory Properties of Some Organic Compounds and Amino Acids. Hacettepe Journal of Biology and Chemistry, Volume: 39 Issue: 2. https://ajindex.com/articles/1271052

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