Journals / Hacettepe Journal of Biology and Chemistry / 2016 / Volume: 44 Issue: 4

Multifunctional Electrospun Biocompatible Nanofiber Composites from Water Dispersion Blends of Folic Acid Conjugated PVP/Dextran/ODA-MMT Nanocomposites and Their Responses to Vero cells

Folik Asit Konjuge Edilmiş PVP/Dekstran/ODA-MMT Nanokompozitlerin Sulu Dispersiyon Karışımlarından Üretilen Çok Fonksiyonlu Elektroeğrilmiş Biyouyumlu Nanofiber Kompozitler ve Bunların Vero Hücreleriyle Etkileşimi

Murat Şimşek(Department of Biomedical Engineering, Faculty of Engineering, İnönü University, Malatya, Turkey.)
Zakir M.o. Rzayev(Department of Nanotechnology and Nanomedicine, The Institute of Science, Hacettepe University, Turkey.)
Ulviya Bunyatova(Department of Biomedical Engineering, Faculty of Engineering, Başkent University, Ankara, Turkey.)
Sevda Khalilova(Scientific Research Institute of Medicinal Prophylaxis, Ministry of Public Health, Baku-Sumgait, Azerbaijan.)
Mustafa Türk(Department of Bioengineering, Faculty of Engineering, Kırıkkale University, Kırıkkale, Turkey.)
Pages
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Publication Date
2016-11-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Cell culture studies showed that NFCs did not exhibit cytotoxicity significantly and also had a low degree of apoptotic and necrotic effects.

📌 3 Key Takeaways

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Objective & Hypothesis:This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofi- ber composites NFCs from water dispersion blends of the intercalated silicate layered nanocomposites of poly 2-vinyl-N-pyrrolidone /octadecyl amine-montmorillonite PVP/ODA-MMT and Dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites, as well as their folic acid FA conjugated derivatives by reactive electrospinning.
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Key Findings & Data:The chemical and physical structures, surface morphology and responses to Vero cells of NFCs were investigated.
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Conclusion & Impact:Cell culture studies showed that NFCs did not exhibit cytotoxicity significantly and also had a low degree of apoptotic and necrotic effects.
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:PVP · Dextran · Nanofiber

Abstract

This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofi- ber composites NFCs from water dispersion blends of the intercalated silicate layered nanocomposites of poly 2-vinyl-N-pyrrolidone /octadecyl amine-montmorillonite PVP/ODA-MMT and Dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites, as well as their folic acid FA conjugated derivatives by reactive electrospinning. The chemical and physical structures, surface morphology and responses to Vero cells of NFCs were investigated. Effects of matrix/partner polymer volume ratios, composition, organoclay and FA on the main important parameters of NFCs were evaluated. Cell culture studies showed that NFCs did not exhibit cytotoxicity significantly and also had a low degree of apoptotic and necrotic effects.

Özet

B u çalışma matris ve partner polimer nanokompozitler olarak poli 2-vinil-N-prolidon /okdadesil aminmontmorillonit PVP/ODA-MMT ve Dekstran/ODA-MMT sulu dispersiyon karışımlarından ve aynı zamanda bunların folik asit FA konjuge edilmiş türevlerinden kolloidal çok fonksiyonlu polimer nanofiber kompozitlerin NFC reaktif elektroeğirme yöntemi ile fabrikasyonunu ve karakterizasyonunu sunmaktadır. NFC’lerin kimyasal ve fiziksel yapıları, morfolojileri ve Vero hücrelerine olan cevapları araştırılmıştır. Matriks/partner polimer oranının, bileşiminin, organokilin ve FA’nın NFC’lerin ana parametreleri üzerindeki etkileri değerlendirilmiştir. Hücre kültür çalışmaları NFC’lerin önemli bir toksik bir etki sergilemediklerini ve ayrıca düşük seviyede apoptotik ve nekrotik etkiye sahip olduklarını göstermiştir

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Cite This Article

Şimşek, M., Rzayev, Z. M., Bunyatova, U., Khalilova, S., Türk, M. (2016). Multifunctional Electrospun Biocompatible Nanofiber Composites from Water Dispersion Blends of Folic Acid Conjugated PVP/Dextran/ODA-MMT Nanocomposites and Their Responses to Vero cells. Hacettepe Journal of Biology and Chemistry, Volume: 44 Issue: 4. https://ajindex.com/articles/1270773

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