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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 45 Issue: 2

Synthesis and Biological Evaluation of New 2-Ethoxy-6-[ 4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl iminomethyl]phenyl 4-nitro-benzoate Derivatives

Yeni 2-Etoksi-6-[ 4,5-dihidro-1H-1,2,4-triazol-5-on-4-il iminometil]fenil 4-nitrobenzoat Türevlerinin Sentezi ve Biyolojik Değerlendirmesi

Haydar Yüksek(Department of Chemistry, Faculty of Science and Letters, Kafkas University, Kars, Turkey)
Faruk Kardaş(Education Faculty, Erzincan University, Erzincan, Turkey.)
Sevda Manap(Department of Chemistry, Faculty of Science and Letters, Kafkas University, Kars, Turkey)
Muzaffer Alkan(Education Faculty, Kafkas University, Kars, Turkey.)
Önder Albayrak(Department of Chemistry, Faculty of Science and Letters, Kafkas University, Kars, Turkey.)
Murat Beytur(Department of Chemistry, Faculty of Science and Letters, Kafkas University, Kars, Turkey)
Özlem Gürsoy-kol(Department of Chemistry, Faculty of Science and Letters, Kafkas University, Kars, Turkey)
Pages
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Publication Date
2017-06-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, these new compounds were screened for their antimicrobial activities.

📌 3 Key Takeaways

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Objective & Hypothesis:In the present study, 3-alkyl aryl -4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-2- 4- nitrobenzoxy -benzaldehyde 2 to afford 2-ethoxy-6-[ 3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl iminomethyl]phenyl 4-nitrobenzoates 3 .
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Key Findings & Data:The structures of new nine compounds were established from the elemental analyses, IR, 1H NMR and 13C NMR spectral data.
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Conclusion & Impact:In addition, these new compounds were screened for their antimicrobial activities.
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:Schiff base · Synthesis · Acetylation

Abstract

In the present study, 3-alkyl aryl -4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-2- 4- nitrobenzoxy -benzaldehyde 2 to afford 2-ethoxy-6-[ 3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl iminomethyl]phenyl 4-nitrobenzoates 3 . The structures of new nine compounds were established from the elemental analyses, IR, 1H NMR and 13C NMR spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. In addition, these new compounds were screened for their antimicrobial activities.

Özet

B u 4-nitrobenzoksi -benzaldehid 2 ile reaksiyona sokularak 2-etoksi-6-[ 3-alkil/aril-4,5-dihidro- 1H-1,2,4triazol-5-on-4-il iminometil]fenil 4-nitrobenzoat 3 bileşikleri elde edildi. Yeni dokuz adet bileşiğin yapısı elementel analiz ve IR, 1H NMR ve 13C NMR spektrum verileri ile aydınlatıldı. Sentezlenen bileşiklerin in vitro potansiyel antioksidan aktiviteleri üç farklı yöntemle analiz edildi. Ayrıca, yeni bileşiklerin antimikrobiyal aktiviteleri incelendi

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Cite This Article

Yüksek, H., Kardaş, F., Manap, S., Alkan, M., Albayrak, Ö., Beytur, M., Gürsoy-kol, Ö. (2017). Synthesis and Biological Evaluation of New 2-Ethoxy-6-[ 4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl iminomethyl]phenyl 4-nitro-benzoate Derivatives. Hacettepe Journal of Biology and Chemistry, Volume: 45 Issue: 2. https://ajindex.com/articles/1270737

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