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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 49 Issue: 3

Tc-99m ile İşaretli Whey Proteinin Deney Hayvanlarındaki Biyodağılımı

Mert Akınlı(Manisa Celal Bayar University, Faculty of Arts and Science, Department of Chemistry)0000-0003-0653-9261
Volkan Tekin(Ege University, Institute of Nuclear Sciences, Department of Nuclear Applications)0000-0002-0264-3814
Fazilet Müftüler(Ege University, Institute of Nuclear Sciences, Department of Nuclear Applications)0000-0001-8184-9660
Gökçen Topal(Manisa Celal Bayar University, Department of Nuclear Medicine, School of Medicine)0000-0002-2268-8921
Yasemin Parlak(Manisa Celal Bayar University, Department of Nuclear Medicine, School of Medicine)0000-0002-3682-7611
Gül Gümüşer(Manisa Celal Bayar University, Department of Nuclear Medicine, School of Medicine)0000-0001-7103-2323
Uğur Avcıbaşı(Manisa Celal Bayar University, Faculty of Arts and Science, Department of Chemistry)0000-0002-3718-4195
Pages
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Publication Date
2021-05-17
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Sonuç olarak, bütün elde edilen sonuçlar Tc-99m ile işaretli Whey protein’in gelecekte meme, yumurtalık ve pankreas kanserlerinin teşhisinde kullanılabileceğini göstermiştir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Bu çalışmanın esas amacı Whey proteinin nükleer tıpta bir görüntüleme ajanı olarak kullanılıp kullanılamayacağını tespit etmektir.
📊
Key Findings & Data:Bunun için; Whey proteini kalay klorür indirgenme metodu kullanılarak Tc-99m ile işaretlenmiştir.
💡
Conclusion & Impact:Sonuç olarak, bütün elde edilen sonuçlar Tc-99m ile işaretli Whey protein’in gelecekte meme, yumurtalık ve pankreas kanserlerinin teşhisinde kullanılabileceğini göstermiştir.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Whey Proteini · Biyodağılım · 99mTc

Abstract

Bu çalışmanın esas amacı Whey proteinin nükleer tıpta bir görüntüleme ajanı olarak kullanılıp kullanılamayacağını tespit etmektir. Bunun için; Whey proteini kalay klorür indirgenme metodu kullanılarak Tc-99m ile işaretlenmiştir. Radyokromatografi çalışmalarında kağıt elektroforezi tekniği kullanılmıştır. Uygun hareketli faz olarak SF (serum fizyolojik) kullanılmıştır. Aynı zamanda Tc-99m ile işaretli Whey protein’in bağlanma verimi yaklaşık %95 olarak bulunmuştur. Daha sonra, sırasıyla lipofilite ve stabilite çalışmaları gerçekleştirilmiştir. Son olarak Albino Wistar sıçanlarda görüntüleme ve biyodağılım çalışmaları yapılmıştır. Sonuç olarak, bütün elde edilen sonuçlar Tc-99m ile işaretli Whey protein’in gelecekte meme, yumurtalık ve pankreas kanserlerinin teşhisinde kullanılabileceğini göstermiştir.

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Cite This Article

Akınlı, M., Tekin, V., Müftüler, F., Topal, G., Parlak, Y., Gümüşer, G., Avcıbaşı, U. (2021). Tc-99m ile İşaretli Whey Proteinin Deney Hayvanlarındaki Biyodağılımı. Hacettepe Journal of Biology and Chemistry, Volume: 49 Issue: 3. https://doi.org/10.15671/hjbc.656021

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