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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 54 Issue: 2

Synthesis and Characterization of s-Triazine Derivatives Containing Theophylline Group, and Some Transition Metal Complexes

Teofilin Grubu İçeren s-Triazin Türevlerinin ve Bazı Geçiş Metal Komplekslerinin Sentezi ve Karakterizasyonu

Ahmet Caymaz(Karabuk University, Faculty of Engineering and Natural Sciences)0009-0005-3771-5856
Ahmed Hamdi Mirghani(Karabuk University, Faculty of Engineering and Natural Sciences)0009-0005-8730-9573
Şaban Uysal(Karabuk University, Faculty of Engineering and Natural Sciences)0000-0003-1061-6143
Pages
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Publication Date
2026-03-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The structures of the complexes were characterized using FTIR, magnetic susceptibility, ICP-OES, and TGA methods.

📌 3 Key Takeaways

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Objective & Hypothesis:In this paper, two novel theophylline-substituted s-triazine ligands and their trinuclear complexes were synthesized.
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Key Findings & Data:Theophylline-7-acetic acid (I) was reacted with thionyl chloride, resulting in chlorination of the acidic moiety to afford 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetyl chloride (II).
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Conclusion & Impact:The structures of the complexes were characterized using FTIR, magnetic susceptibility, ICP-OES, and TGA methods.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Theophylline · Teophylline-7-acetic acid · s-Triazine

Abstract

In this paper, two novel theophylline-substituted s-triazine ligands and their trinuclear complexes were synthesized. Theophylline-7-acetic acid (I) was reacted with thionyl chloride, resulting in chlorination of the acidic moiety to afford 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetyl chloride (II). This compound was reacted separately with o-phenylenediamine and p-phenylenediamine in the presence of AlCl₃ as a catalyst in dichloromethane at -10°C for 24 h. As a result of these reactions, compounds III and IV were obtained. Compounds III and IV were then separately reacted with 2,4,6-tri(p-formylphenoxy)-1,3,5-triazine (TRIPOD) in ethanol, yielding the s-triazine-cored tripodal ligands ACL1 and ACL2. Tripodal transition metal complexes (ACC1-ACC8) were obtained by reacting ACL1 and ACL2 with various transition metal salts (MCl2.nH2O, M=Mn2+, Co2+, Ni2+, and Cu2+). The structures of all obtained ligands were elucidated by 1H and 13C NMR, FTIR, and elemental analysis methods. The structures of the complexes were characterized using FTIR, magnetic susceptibility, ICP-OES, and TGA methods.

Özet

Bu çalışmada, iki yeni teofilin sübstitüe s-triazin ligandı ve bunların trinükleer kompleksleri sentezlendi. Teofilin-7-asetik asit (I), tiyonil klorür ile reaksiyona sokularak asidik kısmın klorlanmasıyla 2-(1,3-dimetil-2,6-diokso-2,3-dihidro-1H-purin-7(6H)-il)asetil klorür (II) elde edildi. Bu bileşik, AlCl3 katalizörlüğünde diklorometan içinde -10°C'de 24 saat boyunca ayrı ayrı o-fenilendiamin ve p-fenilendiamin ile reaksiyona sokuldu. Bu reaksiyonlar sonucunda III ve IV bileşikleri elde edildi. Daha sonra III ve IV bileşikleri, etanol içinde ayrı ayrı 2,4,6-tri(p-formilfenoksi)-1,3,5-triazin (TRIPOD) ile reaksiyona sokularak s-triazin çekirdekli üç ayaklı ligandlar ACL1 ve ACL2 elde edildi. Tripodal geçiş metal kompleksleri (ACC1-ACC8), ACL1 ve ACL2'nin çeşitli geçiş metal tuzları (MCl2.nH2O, M=Mn2+, Co2+, Ni2+ ve Cu2+) ile reaksiyonu sonucu elde edildi. Elde edilen tüm ligandların yapıları 1H ve 13C NMR, FTIR ve elementel analiz yöntemleriyle aydınlatıldı. Komplekslerin yapıları ise FTIR, manyetik duyarlılık, ICP-OES ve TGA yöntemleri kullanılarak karakterize edildi.

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Cite This Article

Caymaz, A., Mirghani, A. H., Uysal, Ş. (2026). Synthesis and Characterization of s-Triazine Derivatives Containing Theophylline Group, and Some Transition Metal Complexes. Hacettepe Journal of Biology and Chemistry, Volume: 54 Issue: 2. https://doi.org/10.15671/hjbc.1770103

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