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Journals / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 54 Issue: 3

LC–MS/MS-Based Identification and ADMET Profiling of Vitamin and Antioxidant Compounds from Tenebrio molitor with Antibacterial and Antibiofilm Activities Against Foodborne Pathogens

Gıda Kaynaklı Patojenlere Karşı Antibakteriyel ve Antibiyofilm Aktiviteleri Olan Tenebrio molitor'dan Elde Edilen Vitamin ve Antioksidan Bileşiklerin LC–MS/MS Tabanlı Tanımlanması ve ADMET Profili Oluşturulması

Didem Berber(maltepe üniversitesi)0000-0001-5813-160X
Orçun Toksöz(MARMARA UNIVERSITY)0000-0002-4863-3232
Yavuz Turan(MARMARA UNIVERSITY)0000-0001-9727-040X
Dença Toker(MARMARA UNIVERSITY)0009-0003-1805-3063
Cenk Sesal(MARMARA UNIVERSITY)0000-0002-0737-0122
Pages
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Publication Date
2026-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results demonstrated that high abundance vitamin B1 and vitamin B2 as vitamins, and quercetin, luteolin, and apigenin as antioxidant compounds.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Edible insects have been highlighted as an alternative source for functional food formulations.
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Key Findings & Data:The results demonstrated that high abundance vitamin B1 and vitamin B2 as vitamins, and quercetin, luteolin, and apigenin as antioxidant compounds.
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Conclusion & Impact:Functional food ingredients can be analysed by computational analyses in the food R&D process.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tenebrio molitor · ADMET · LC-MS/MS

Abstract

Edible insects have been highlighted as an alternative source for functional food formulations. Tenebrio molitor, has been reported to be a more acceptable insect to humans. This study aimed to identify vitamins and antioxidant compounds present in T. molitor larvae by LC-MS/MS analysis. These compounds were analyzed for their Absorption, Distribution, Metabolism, Excretion, Toxicological (ADMET) profiles. Antibacterial and antibiofilm potential of extracts of T. molitor larvae against several foodborne pathogens were determined. The results demonstrated that high abundance vitamin B1 and vitamin B2 as vitamins, and quercetin, luteolin, and apigenin as antioxidant compounds. The extracts showed high levels of antibiofilm activity. Functional food ingredients can be analysed by computational analyses in the food R&D process.

Özet

Yenilebilir böcekler, fonksiyonel gıda formülasyonları için alternatif bir kaynak olarak öne çıkmaktadır. Tenebrio molitor’ün insanlar için daha kabul edilebilir bir böcek olduğu bildirilmiştir. Bu çalışma, LC–MS/MS analizi kullanarak T. molitor larvalarında bulunan vitaminleri ve antioksidan bileşikleri tanımlamak ve miktarlarını belirlemek amacıyla yapılmıştır. Bu bileşikler, Emilim, Dağılım, Metabolizma, Atılım ve Toksikolojik (ADMET) profilleri açısından analiz edildi. T. molitor larvalarının ekstraktlarının çeşitli gıda kaynaklı patojenlere karşı antibakteriyel ve antibiyofilm potansiyeli belirlenmiştir. Sonuçlar, vitaminler olarak yüksek miktarda vitamin B1 ve vitamin B2 ile antioksidan bileşikler olarak quercetin, luteolin ve apigenin bulunduğunu göstermiştir. Ekstraktlar, yüksek düzeyde antibiyofilm aktivitesi göstermiştir. Fonksiyonel gıda bileşenleri, gıda Ar-Ge sürecinde hesaplamalı analizlerle analiz edilebilir.

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Cite This Article

Berber, D., Toksöz, O., Turan, Y., Toker, D., Sesal, C. (2026). LC–MS/MS-Based Identification and ADMET Profiling of Vitamin and Antioxidant Compounds from Tenebrio molitor with Antibacterial and Antibiofilm Activities Against Foodborne Pathogens. Hacettepe Journal of Biology and Chemistry, Volume: 54 Issue: 3. https://doi.org/10.15671/hjbc.1834431

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