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Journals / Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi / 2026 / Cilt: 41 Sayı: 2

Antioxidant, Anti-inflammatory, and Anti-aging Effects of a Synergistic Herbal Formulation

Sinerjik Bir Bitkisel Formülasyonun Antioksidan, Antienflamatuar ve Yaşlanma Karşıtı Etkileri

Hasan Basri Karayel(Dumlupınar üni. Gediz MYO)
Serhat Karaman(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0003-4554-1364
Yakup Budak(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0001-7108-5548
Pages
535–547
Publication Date
2025-08-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The triple combination exhibited superior activity to single extracts and may be a safe and compelling candidate for skin health.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Abstract: This study investigated the dermatological effects of a synergistic phytocomplex prepared from ethanolic extracts of Achillea millefolium, Symphytum officinale, and Matricaria chamomilla.
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Key Findings & Data:Bioactive components were analyzed, and the formulated serum's antioxidant, anti-inflammatory, and anti-aging (collagenase, elastase inhibition) potential was evaluated.
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Conclusion & Impact:The triple combination exhibited superior activity to single extracts and may be a safe and compelling candidate for skin health.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Antioksidan Aktivite · Cilt Sağlığı · Achillea millefolium

Abstract

Abstract: This study investigated the dermatological effects of a synergistic phytocomplex prepared from ethanolic extracts of Achillea millefolium, Symphytum officinale, and Matricaria chamomilla. Bioactive components were analyzed, and the formulated serum's antioxidant, anti-inflammatory, and anti-aging (collagenase, elastase inhibition) potential was evaluated. Physicochemical stability, structural characterization (FTIR), and in vitro release studies were performed. Multifunctional serum (MFS) showed no cytotoxic effect in human dermal fibroblast (HDF) and keratinocyte (HaCaT) cells. The triple combination exhibited superior activity to single extracts and may be a safe and compelling candidate for skin health.

Özet

Öz: Bu çalışmada Achillea millefolium, Symphytum officinale ve Matricaria chamomilla'nın etanolik ekstrelerinden hazırlanan sinerjik bir fitokompleksin dermatolojik etkileri araştırılmıştır. Biyoaktif bileşenler analiz edilmiş ve formüle edilen serumun antioksidan, anti-enflamatuar ve yaşlanma karşıtı (kolajenaz, elastaz inhibisyonu) potansiyeli değerlendirilmiştir. Fizikokimyasal stabilite, yapısal karakterizasyon (FTIR) ve in vitro salım çalışmaları gerçekleştirilmiştir. Çok fonksiyonlu serum (MFS) insan dermal fibroblast (HDF) ve keratinosit (HaCaT) hücrelerinde sitotoksik etki göstermemiştir. Üçlü kombinasyon, tekli ekstraktlardan daha üstün aktivite sergilemiştir ve cilt sağlığı için güvenli ve cazip bir aday olabilir.

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Cite This Article

Karayel, H. B., Karaman, S., Budak, Y. (2025). Antioxidant, Anti-inflammatory, and Anti-aging Effects of a Synergistic Herbal Formulation. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, Cilt: 41 Sayı: 2, 535–547. https://ajindex.com/articles/1266660

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