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Journals / Eurasian Journal of Medicine and Oncology / 2019 / Cilt: 3 - Sayı: 1

Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in Rats

AHMET MİDİ
ALİ KUMANDAŞ
HÜSAMETTİN EKİCİ
Feyzanur BAYRAKTAR
Kübra KARAPİRLİ
SİYAMİ KARAHAN
MUSTAFA TÜRK
H. Emel ÖZYÜREK
Pages
37–42
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: This study showed that AHA is a highly effective hemostatic agent in controlling bleeding compared to the control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Bleeding control is crucial in preventing negative consequences by reducing blood loss in surgical operations.
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Key Findings & Data:Methods: In these study 5–7 weeks-old 64 rats were used.
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Conclusion & Impact:Conclusion: This study showed that AHA is a highly effective hemostatic agent in controlling bleeding compared to the control group.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Bleeding control is crucial in preventing negative consequences by reducing blood loss in surgical operations. The aim of this study is to evaluate the hemostatic effect of a new herbal hemostatic agent called Algan Hemostatic Agent (AHA) in an uncontrolled bleeding model made by liver laceration. Methods: In these study 5–7 weeks-old 64 rats were used. Rats were randomly divided into 8 groups each consisting of eight rats (4 groups heparinize and 4 groups non-heparinize). The experimental liver laceration was performed, and physiological serum impregnated gauze was applied to the control group for hemorrhage control, AHA liquid form impregnated gauze, AHA gel, and AHA powder form were applied to experimental groups, respectively. Results: The shortest bleeding time was found in the AHA powder group. The AHA powder form stopped the bleeding in the heparinize group for a mean of 4 s, the non-heparinized group for 2 s. This was followed by the gel group and the liquid group. The bleeding time was significantly shorter in the all AHA group compared to the control group. Conclusion: This study showed that AHA is a highly effective hemostatic agent in controlling bleeding compared to the control group.

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Cite This Article

MİDİ, A., KUMANDAŞ, A., EKİCİ, H., BAYRAKTAR, F., KARAPİRLİ, K., KARAHAN, S., TÜRK, M., ÖZYÜREK, H. E. (2019). Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in Rats. Eurasian Journal of Medicine and Oncology, Cilt: 3 - Sayı: 1, 37–42. https://ajindex.com/articles/126026

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References (14)

  1. Romano F, Franciosi C, Caprotti R, Uggeri F. Hepatic surgery using the ligasure vessel sealing system. World J Surg 2005;29:110–2
  2. Kopelman D, Klein Y, Zaretsky A, Ben-Izhak O, Michaelson M, Hashmonai M, et al. Cryohemostasis of uncontrolled hemorrhage from liver injury. Cryobiology 2000;40:210–7
  3. Carmona RH, Lim RC Jr. Clark GC. Morbidity and mortality in hepatic trauma. A 5 year study. Am J Surg 1982;144:88–94
  4. Laurent C, Blanc JF, Nobili S, Sa Cunha A, le Bail B, Bioulac-Sage P, et al. Prognostic factors and longterm survival after hepatic resection for hepatocellular carcinoma originating from noncirrhotic liver. J Am Coll Surg 2005;201:656–62
  5. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: Analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397–406
  6. Ruitenbeek K, Ayez N, Verhoef C, de Wilt JH, Bottema J, Rijken AM, et al. Safety and efficacy of a novel, dry powder fibrin sealant for hemostasis in hepatic resection. Dig Surg 2014;31:422–7
  7. Gage AA, Baust J. Mechanisms of tissue injury in cryosurgery. Cryobiology 1998;37:171–86
  8. Ersoy G, Kaynak MF, Yilmaz O, Rodoplu U, Maltepe F, Gokmen N, et al. Hemostatic effects of microporous polysaccharide hemosphere in a rat model with severe femoral artery bleeding. Adv Ther 2007;24:485–92
  9. Saiura A, Yamamoto J, Koga R, Sakamoto Y, Kokudo N, Seki M, et al. Usefulness of ligaSure for liver resection: Analysis by randomized clinical trial. Am J Surg 2006;192:41–5
  10. Davidson BR, Burnett S, Javed MS, Seifalian A, Moore D, Doctor N, et al. Experimental study of a novel fibrin sealant for achieving haemostasis following partial hepatectomy. Br J Surg 2000;87:790–5
  11. CoStasis Multi-center Collaborative Writing Committee. A novel collagen-based composite offers effective hemostasis for multiple surgical indications: Results of a randomized controlled trial. Surgery 2001;129:445–50
  12. Nakajima Y, Shimamura T, Kamiyama T, Matsushita M, Sato N, Todo S, et al. Control of intraoperative bleeding during liver resection: Analysis of a questionnaire sent to 231 Japanese hospitals. Surg Today 2002;32:48–52
  13. Akarsu C, Kalaycı MU, Yavuz E, Ozkara S, Gökçek B, Ozdenkaya Y, et al. Comparison of the hemostatic efficiency of ankaferd blood stopper and fibrin glue on a liver laceration model in rats. Ulus Travma Acil Cerrahi Derg 2011;17:308–12
  14. Jackson MR. New and potential uses of f