Journals / Eurasian Journal of Medicine and Oncology / 2019 / Cilt: 3 - Sayı: 3

Her-2 Discordance Between Primer and Metastasis in Atypical Presentation of Metastatic Breast Cancer at the Time of Diagnosis: A Case Report

Pages
231–235
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Breasts and the gastrointestinal tract are the most common sites of the primary tumor.Several studies have carried out retrospective analyses comparing the ER, PR, and HER2 status of primary tumors and paired metastasis.We reported that HER2 discordance between primary and metastatic lesion in a 70-years old, postmenopausal woman who was diagnosed as invasive ductal carcinoma (IDC) with bone and endometrial metastases at the time of diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Breast cancer (BC) is the most common female cancer, the second most common cause of cancer death in women, and the main cause of death in women ages 40–59.The most common sites of BC metastases are liver, lung and bones.
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Key Findings & Data:Metastases to the female genital tract from extragenital cancers are rare.
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Conclusion & Impact:Breasts and the gastrointestinal tract are the most common sites of the primary tumor.Several studies have carried out retrospective analyses comparing the ER, PR, and HER2 status of primary tumors and paired metastasis.We reported that HER2 discordance between primary and metastatic lesion in a 70-years old, postmenopausal woman who was diagnosed as invasive ductal carcinoma (IDC) with bone and endometrial metastases at the time of diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Breast cancer (BC) is the most common female cancer, the second most common cause of cancer death in women, and the main cause of death in women ages 40–59.The most common sites of BC metastases are liver, lung and bones. Metastases to the female genital tract from extragenital cancers are rare. Breasts and the gastrointestinal tract are the most common sites of the primary tumor.Several studies have carried out retrospective analyses comparing the ER, PR, and HER2 status of primary tumors and paired metastasis.We reported that HER2 discordance between primary and metastatic lesion in a 70-years old, postmenopausal woman who was diagnosed as invasive ductal carcinoma (IDC) with bone and endometrial metastases at the time of diagnosis.

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Cite This Article

ÖNER, İ., ŞEN, E., GEDİK, G. K., KELEŞ, B., UĞURLUOĞLU, C., ATA, Ö. (2019). Her-2 Discordance Between Primer and Metastasis in Atypical Presentation of Metastatic Breast Cancer at the Time of Diagnosis: A Case Report. Eurasian Journal of Medicine and Oncology, Cilt: 3 - Sayı: 3, 231–235. https://ajindex.com/articles/125645

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References (10)

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin 2009
  2. 225–49. 2. Famoriyo A, Sawant S, BanWeld PJ. Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer on tamoxifen therapy. Arch Gynecol Obstet 2004
  3. 192–3. 3. Piura B, Yanai-Inbar I, Rabinovich A, Zalmanov S, Goldstein J. Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol 1999
  4. 57–61. 4. Karvouni E, Papakonstantinou K, Dimopoulou C, Kairi-Vassilatou E, Hasiakos D, Gennatas CG, Kondi-Paphiti A. Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. Arch Gynecol Obstet 2009
  5. 199–201. 5. N. B. Kumar, W. R. Hart, “Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases,” Cancer, vol. 50, no. 10, pp. 2163–2169, 1982. 6. M. T. Mazur, S. Hsueh, and D. J. Gersell, “Metastases to the female genital tract. Analysis of 325 cases,” Cancer, vol. 53, no. 9, pp. 1978–1984, 1984. 7. Silverberg SG, Kurman RJ (1992) Atlas of Tumor Pathology: Tumors of the Uterine Corpus and Gestational Trophoblastic Disease, 3rd edn. Washington, 7 Armed Forces Institute of Pathology. 8. Mazur MT, Hsueh S, Gersell DJ. Metastases to the female genital tract. Analysis of 325 cases. Cancer 1984
  6. 1978–84. 9. Scopa CD, Aletra C, Lifschitz-Mercer B, Czernobilsky B: Metastases of breast carcinoma to the uterus. Report of two cases, one harboring a primary endometrioid carcinoma, with review of the literature. Gynecol Oncol 2005
  7. 543–7. 10. Erkanli S, Kayaselcuk F, Kuscu E, Bolat F, Sakalli H, Haberal A. Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrazole therapy. Breast 2005
  8. 558–61. 11. Acıkalin MF, Oner U, Tekin B, Yavuz E, Cengiz O. Metastasis from breast carcinoma to a tamoxifen related endometrial polyp. Gynecol Oncol 2005
  9. 946–8. 12. Di Bonito L, Patriarca S, Alberico S. Breast carcinomametastasizing to the uterus. Eur J Gynaecol Oncol 1985
  10. 211–7. 13. B. Piura, I. Yanai-Inbar, A. Rabinovich, S. Zalmanov, and J. Goldstein, “Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 83, n