-

Objective & Hypothesis:Leukoplakia considered as the most common premalignant oral lesion of the oral cavity and defined as, “a white patch or plaque that cannot be characterized clinically as any other disease”.

📊

Key Findings & Data:Precancerous lesions including oral leukoplakia have a benign biological, but the histopathological examination demonstrates atypical cells confined to the epidermis.

💡

Conclusion & Impact:In this case transformation of leukoplakia into oral squamous cell carcinoma is reported.

🔬Design:Article

📍Scope:Comprehensive Sample

⚙️Variables:Leukoplakia · malign transformation · oral cancer

Abstract

Leukoplakia considered as the most common premalignant oral lesion of the oral cavity and defined as, “a white patch or plaque that cannot be characterized clinically as any other disease”. Precancerous lesions including oral leukoplakia have a benign biological, but the histopathological examination demonstrates atypical cells confined to the epidermis. These lesions have carcinogenic potential. Patients should be followed up in terms of malignancy risk. In this case transformation of leukoplakia into oral squamous cell carcinoma is reported.

Özet

ÖZ Oral lökoplaki, oral mukozada en sık görülen premalign lezyon olup klinik ya da patolojik olarak herhangi bir hastalığa ait olmayan beyaz-gri plaklar ile karakterizedir. Lökoplakinin de dahil olduğu premalign lezyonlar, biyolojik davranışı selim olan ancak histopatolojik olarak hücrelerde atipi kriterleri ve maligniteye dönüşme potansiyeli taşıyan lezyonlardır. Premalign lezyonların başlangıcından itibaren düşük dereceli maligniteler olarak değerlendirilerek belirli aralıklarla takip edilmeleri önerilmektedir. Bu olguda oral lökoplaki tanısıyla takip edilen hastada lökoplakinin malign transformasyon ile oral skuamoz hücreli karsinom gelişimi göstermesi rapor edilmiştir. Anahtar kelimeler: Lökoplaki, malign transformasyon, oral kanser ABSTRACT Leukoplakia considered as the most common premalignant oral lesion of the oral cavity and defined as, "a white patch or plaque that cannot be characterized clinically as any other disease". Precancerous lesions including oral leukoplakia have a benign biological, but the histopathological examination demonstrates atypical cells confined to the epidermis. These lesions have carcinogenic potential. Patients should be followed up in terms of malignancy risk. In this case transformation of leukoplakia into oral squamous cell carcinoma is reported. Keywords: Leukoplakia, malign transformation, oral cancer

Keywords

Leukoplakia malign transformation oral cancer

🔖

Cite This Article

Saruhanoğlu, A., Altın, N., Ergun, S., Tanyeri, H. (2013). -. European Oral Research, Volume: 47 Issue: 2. https://ajindex.com/articles/1255109

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (14)

Liu W, Wang YF, Zhou HW, Shi P, Zhou ZT, Tang GY, Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients. BMC Cancer, 2010; 10: 685. Papadimitrakopoulou VA, Hong WK, Lee JS, Martin JW, Lee JJ, Batsakis JG, Lippman SM. Low-dose isotretinoin versus beta-carotene to prevent oral carcinogenesis: long-term follow-up. J Natl Cancer Inst, 1997; 89(3): 257–58. Mithani SK, Mydlarz WK, Grumbine
FL, Smith IM, Califano JA. Molecular genetics of premalignant oral lesions. Oral Dis, 2007; 13(2): 126-33. Reibel J. Prognosis of oral premalignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med, 2003; 14(1): 47-62. Sciubba JJ. Oral cancer. The importance of early diagnosis and treatment. Am
J Clin Dermatol, 2001; 2(4): 239-51. van der Waal I, Schepman KP, van der Meij EH, Smeele LE. Oral leukoplakia: a clinicopathological review. Oral Oncol, 1997; 33(5): 291-301. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med, 2007; 36(10): 575–80. Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review.
Oral Oncol, 2003; 39(8): 770-80. Saito T, Sugiura C, Hirai A, Notani K, Totsuka Y, Shindoh M, Fukuda H. Development of squamous cell carcinoma from pre-existent oral leukoplakia: with respect to treatment modality. Int J Oral Maxillofac Surg, 2001; 30(1): 49–53.
Fischer DJ, Epstein JB, Morton TH, Schwartz SM. Interobserver reliability in the histopathologic diagnosis of oral premalignant and malignant lesions. J Oral Pathol Med, 2004; 33(2): 65-70.
Sarp JP, Eversole LR, Wysocki GP. Contemporary oral and maxillofacial pathology. St. Louis: Mosby, 1997, p.156-95. Ma N, Tagawa T, Hiraku Y, Murata M, Ding X, Kawanishi S. 8-Nitroguanine formation in oral leukoplakia a premalignant lesion. Nitric Oxide, 2006; 14(2): 137–43.
Huber MA. White oral lesions, actinic cheilitis, and leukoplakia: confusions in terminology and definition: facts and controversies. Clin Dermatol, 2010; 28(3): 262–68. Öztürk B, Coşkun U, Yaman E, Kaya AO, Yıldız R, Benekli M, Büyükberber S. Oral kavite kanserlerinde risk faktörleri, premalign lezyonlar ve kemoprevensiyon. UHOD, 2009; 19(2): 117-26.
Waldron CA, Shafer WG. Leukoplakia revisited: a clinicopathologic study 3256 oral leukoplakias. Cancer, 1975; 36(4): 1386Martorell-Calatayud A, Botella-Estrada R, Bagán-Sebastián JV, SanmartínJiménez O, Guillén-Baronaa C. Oral leukoplakia: clinical, histopathologic and molecular features and therapeutic approach. Actas Dermosifiliogr, 2009; 100(8): 669-84. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral & maxillofacial pathology. Philadelphia: Saunders, 2002.
Maserejian NN, Joshipura KJ, Rosner BA, Giovannucci E, Zavras AI. Prospective study of alcohol consumption and risk of oral premalignant lesions in men. Cancer Epidemiol Biomarkers Prev, 2006; 15(4): 774–81. Ünür M, Dogan Onur Ö. Ağız hastalıklarının teşhis ve tedavisi. İstanbul: Quintessence Yayıncılık, 2003. Cawson RA, Odell EW. Essentials of oral pathology and medicine. 6th ed., Edinburgh: Churchill Livingstone, 1998. Longshore SJ, Camisa C. Detection and management of premalignant oral leukoplakia. Dermatologic Theraphy, 2002; 15(3): 229-35. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin, 2002; 52(4): 195–215. Sciubba JJ. Oral leukoplakia. Crit Rev
Oral Biol Med, 1995; 6(2): 147-60. Haya-Fernandez MC, Bagan JV, Murillo-Cortes J, Poveda-Roda R, Calabuig C.
The prevalence of oral leukoplakia in 138 patients with oral squamous cell carcinoma. Oral Disease, 2004; 10(6): 346-48. Ak G, Ünür M. Lökoplaki kökenli epidermoid karsinom (2 vaka nedeni ile). İstanbul Üniv Diş Hek Fak Derg, 1998; 32(1): 34- Lodi G, Sardella A, Bez C, Demarosi
F, Carrassi A. Interventions for treating oral leukoplakia (review). The Cochrane Library, 2007; 4: 1-24. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Long-term treatment outcome of oral premalignant lesions. Oral Oncol, 2006; 42(5): 461-74. Yazışma Adresi Alp Saruhanoğlu
İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız Diş ve Çene Cerrahisi A. D. 34093 Çapa- Fatih / İstanbul Telefon: 0212 4142020/ 30353 e-posta: [email protected]
İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız Diş ve Çene Cerrahisi A. D. 34093 Çapa- Fatih / İstanbul Telefon: 0212 4142020/ 30353 e-posta: [email protected]