SavedAdd your journal

Journals / KONURALP TIP DERGİSİ / 2025 / Volume: 17 Issue: 3

Contemporary Implications of Incidental Prostate Cancer in Radical Cystoprostatectomy

Radikal Sistoprostatektomide Saptanan İnsidental Prostat Kanserinin Güncel Klinik Yansımaları

Günal Özgür(MARMARA UNIVERSITY)0000-0002-3847-0089
Yusuf Şenoğlu(MARMARA UNIVERSITY)0000-0002-3072-9252
Halil Batur Akay(MARMARA UNIVERSITY)0000-0001-8194-5935
Murat Kars(MARMARA UNIVERSITY)0000-0001-8592-5691
Hasan Toper(MARMARA UNIVERSITY)0000-0002-2009-6164
İlker Tınay(Anadolu Medical Center)0000-0001-6768-9373
Haydar Kamil Çam(MARMARA UNIVERSITY)0000-0002-8275-5479
Pages
—
Publication Date
2025-10-29
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No difference in overall survival rates was found between patients with and without IPC [16 (32.7%) vs. 14 (29.8%)] (p=0.762).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to document the incidence, histopathologic characteristics, and clinical features of incidental prostate cancer (IPC) in a series of radical cystoprostatectomies (RCP).
📊
Key Findings & Data:Method: The clinical and histopathological features of 96 male patients who underwent RCP between 2018 and 2024 were retrospectively evaluated.
💡
Conclusion & Impact:No difference in overall survival rates was found between patients with and without IPC [16 (32.7%) vs. 14 (29.8%)] (p=0.762).
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Bladder Cancer · Prostate Cancer · Radical Cystectomy

Abstract

Objective: The aim of this study was to document the incidence, histopathologic characteristics, and clinical features of incidental prostate cancer (IPC) in a series of radical cystoprostatectomies (RCP). Method: The clinical and histopathological features of 96 male patients who underwent RCP between 2018 and 2024 were retrospectively evaluated. Results: IPC was detected in 30 (31.25%) of the patients. The majority of patients with IPC had a Gleason Score of 6 (76.67%) and organ-confined pT1-pT2 disease (90%). On the other hand, 6 (6/30, 20%) of the patients with ICP had clinically significant prostate cancer (PC) (Gleason > 3+4). Preoperative PSA values were higher in IPC patients (3.27 [1.16-5.8] ng/dL vs. 1.24 [0.79-2.36] ng/dL) (p=0.01). Survival was lower in patients with pT3-pT4 disease [13 (26.5%) vs. 25 (53.2%)], positive lymph nodes [7 (14.3%) vs. 16 (34%)], and lymphovascular invasion [12 (24.5%) vs. 29 (61.7%)] (p=0.015, 0.023, and 0.001, respectively) in the pathology of bladder cancer (BC). No difference in overall survival rates was found between patients with and without IPC [16 (32.7%) vs. 14 (29.8%)] (p=0.762). Conclusions: A higher preoperative PSA level could predict the presence of IPC in RCP patients. Approximately 20% of the PC patients had clinically significant PC, which requires PSA monitoring. However, overall survival is primarily related to BC.

Özet

Amaç: Bu çalışmanın amacı, radikal sistoprostatektomi (RSP) uygulanan hastalarda insidental prostat kanseri (İPK) insidansını, histopatolojik özelliklerini ve klinik bulgularını değerlendirmektir. Yöntem: 2018–2024 yılları arasında RSP uygulanan 96 erkek hastanın klinik ve histopatolojik özellikleri retrospektif olarak değerlendirildi. Bulgular: Hastaların 30’unda (%31,25) İPK saptandı. İPK saptanan hastaların büyük çoğunluğunda Gleason skoru 6 (%76,67) ve organa sınırlı (pT1–pT2) tümör (%90) mevcuttu. İPK saptanan 6 hastada (6/30, %20) klinik olarak anlamlı prostat kanseri (Gleason > 3+4) saptandı. Preoperatif PSA düzeyleri İPK saptanan hastalarda daha yüksekti (3,27 [1,16–5,8] ng/dL’ye karşılık 1,24 [0,79–2,36] ng/dL) (p=0,01). Mesane kanseri (MK) patolojisinde evre pT3–pT4 hastalık olan, lenf nodu metastazı bulunan ve lenfovasküler invazyon gösteren hastalarda sağkalım oranları daha düşüktü [sırasıyla 13 (%26,5) vs. 25 (%53,2); 7 (%14,3) vs. 16 (%34); 12 (%24,5) vs. 29 (%61,7)] (p=0,015, 0,023 ve 0,001). İPK varlığı ile genel sağkalım oranları arasında anlamlı bir fark saptanmadı [İPK olanlarda 16 (%32,7) vs. olmayanlarda 14 (%29,8)] (p=0,762). Sonuç: Yüksek preoperatif PSA düzeyleri, RSP uygulanan hastalarda İPK varlığının öngörücüsü olabilir. Prostat kanseri saptanan olguların yaklaşık %20’sinde klinik olarak anlamlı prostat kanseri mevcut olup, bu hastalarda PSA takibi önerilmektedir. Bununla birlikte, genel sağkalım esas olarak mesane kanseri ile ilişkilidir.

🔖

Cite This Article

Özgür, G., Şenoğlu, Y., Akay, H. B., Kars, M., Toper, H., Tınay, İ., Çam, H. K. (2025). Contemporary Implications of Incidental Prostate Cancer in Radical Cystoprostatectomy. KONURALP TIP DERGİSİ, Volume: 17 Issue: 3. https://doi.org/10.18521/ktd.1674768

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12-49.
  2. Bell KJ, Del Mar C, Wright G, Dickinson J, Glasziou P. Prevalence of incidental prostate cancer: A systematic review of autopsy studies. Int J Cancer. 2015;137(7):1749-57.
  3. Cornford P, van den Bergh RCN, Briers E, van den Broeck T, Brunckhorst O, Darraugh J, et al. EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer-2024 update. part I: screening, diagnosis, and local treatment with curative intent. Eur Urol. 2024;86(2):148-63.
  4. Lopez-Beltran A, Cheng L, Montorsi F, Scarpelli M, Raspollini MR, Montironi R. Concomitant bladder cancer and prostate cancer: challenges and controversies. Nat Rev Urol. 2017;14(10):620-9.
  5. Buse S, Höfner T, Müller SC, Hermann E, Wieland WF, May M, et al. Characterization and risk stratification of prostate cancer in patients undergoing radical cystoprostatectomy. Int J Urol. 2013;20(9):866-71.
  6. Sruogis A, Ulys A, Smailyte G, Kardelis Z, Kulboka A, Anglickienė G, et al. Incidentally found prostate cancer and influence on overall survival after radical cystoprostatectomy. Prostate Cancer. 2012;2012:690210.
  7. Kimura T, Onuma H, Sato S, Inaba H, Fukuokaya W, Urabe F, et al. Incidental prostate cancer in radical cystoprostatectomy specimens is associated with worse overall survival. Bladder Cancer. 2021;7(2):205-11.
  8. Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Stenzl A, Gakis G. Clinicopathological features and prognostic value of incidental Prostatic Adenocarcinoma in radical cystoprostatectomy specimens: a systematic review and meta-analysis of 13,140 patients. J Urol. 2017;197(2):385-90.
  9. Jønck S, Helgstrand JT, Røder MA, Klemann N, Grønkaer Toft B, Brasso K. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis. Scand J Urol. 2018;52(5-6):358-63.
  10. Pignot G, Salomon L, Neuzillet Y, Masson-Lecomte A, Lebacle C, Patard JJ, et al. Clinicopathological characteristics of incidental prostate cancer discovered from radical cystoprostatectomy specimen: a multicenter French study. Ann Surg Oncol. 2014;21(2):684-90.
  11. Malte R, Kluth LA, Kaushik D, Boorjian SA, Abufaraj M, Foerster B, et al. Frequency and prognostic significance of incidental prostate cancer at radical cystectomy: results from an international retrospective study. Eur J Surg Oncol. 2017;43(11):2193-9.
  12. Scilipoti P, Liedberg F, Garmo H, Orrason AW, Stattin P, Westerberg M. Risk of prostate cancer death in men diagnosed with prostate cancer at cystoprostat¬ectomy. A nationwide population-based study. Scand J Urol. 2024;59:98-103.
  13. Tang S, Hao H, Fang D, Zheng W, Ge P, Su X, et al. Prostate cancer incidentally discovered at the time of radical cystoprostatectomy does not decrease overall survival: results from a large Chinese medical center. Int Braz J Urol. 2018;44(2):258-66.
  14. Wu K, Liu X, Tang Y, Wang X, Li X. Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study. Int J Surg. 2024;110(7):4023-30.
  15. Bruins HM, Djaladat H, Ahmadi H, Sherrod A, Cai J, Miranda G, et al. Incidental prostate cancer in patients with bladder urothelial carcinoma: comprehensive analysis of 1,476 radical cystoprostatectomy specimens. J Urol. 2013;190(5):1704-9.
  16. Kaelberer JB, O'Donnell MA, Mitchell DL, Snow AN, Mott SL, Buatti JM, et al. Incidental prostate cancer diagnosed at radical cystoprostatectomy for bladder cancer: disease-specific outcomes and survival. Prostate Int. 2016;4(3):107-12.
  17. Li S, Chen R, Raj A, Xue N, Zhao F, Shen X, et al. Impact of the time of surgical delay on survival in patients with muscle-invasive bladder cancer. Front Oncol. 2022;12:1001843.
  18. Kutikov A, Weinberg DS, Edelman MJ, Horwitz EM, Uzzo RG, Fisher RI. A war on two fronts: cancer care in the Time of COVID-19. Ann Intern Med. 2020;172(11):756-8.
  19. Naspro R, Da Pozzo LF. Urology in the time of corona. Nat Rev Urol. 2020;17(5):251-3.