Cholesterol efflux from sperm: approaches and applications

Key Findings & Data:To attain functional capability or capacitation in vivo, sperm must reside in the female reproductive tract for a certain period of time before fertilization.

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Conclusion & Impact:This review provides insight to researchers designing new procedures for sperm preparation to be used in assisted reproductive technology.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Cholesterol efflux · sperm · capacitation

Abstract

Following ejaculation, sperm appear morphologically mature, but functionally they are inactive. To attain functional capability or capacitation in vivo, sperm must reside in the female reproductive tract for a certain period of time before fertilization. In the female reproductive tract, cholesterol efflux from the sperm plasma membrane is considered vital for the initiation of capacitation. A number of in vitro studies have used biological and nonphysiological means to understand the phenomenon of cholesterol efflux and capacitation. In this review, we present a short overview of the role of cholesterol efflux in regulating sperm capacitation using various agents. This review provides insight to researchers designing new procedures for sperm preparation to be used in assisted reproductive technology.

Özet

Following ejaculation, sperm appear morphologically mature, but functionally they are inactive. To attain functional capability or capacitation in vivo, sperm must reside in the female reproductive tract for a certain period of time before fertilization. In the female reproductive tract, cholesterol efflux from the sperm plasma membrane is considered vital for the initiation of capacitation. A number of in vitro studies have used biological and nonphysiological means to understand the phenomenon of cholesterol efflux and capacitation. In this review, we present a short overview of the role of cholesterol efflux in regulating sperm capacitation using various agents. This review provides insight to researchers designing new procedures for sperm preparation to be used in assisted reproductive technology.

Keywords

Cholesterol efflux sperm capacitation in vitro fertilization

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Cite This Article

NASEER, Z., AHMAD, E., AKSOY, M. (2014). Cholesterol efflux from sperm: approaches and applications. Turkish Journal of Veterinary and Animal Sciences, Cilt: 38 - Sayı: 6, 653–659. https://ajindex.com/articles/121545

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