Journals / Journal of Basic and Clinical Health Sciences / 2025 / Volume: 9 Issue: 3

Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels

Damla Gül Fındık(BİLECİK ŞEYH EDEBALİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8028-627X
Özlem Türelik(BİLECİK ŞEYH EDEBALİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6057-9171
Pages
—
Publication Date
2025-09-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial.
📊
Key Findings & Data:Elevated serum vitamin D levels above 60 nmol/L (24 ng/mL) have been linked to increased basal cell carcinoma risk.
💡
Conclusion & Impact:Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.
🔬Design:Research Article
📍Scope:2014-2024 Verileri
⚙️Variables:Calcifediol · Neoplasm Invasiveness · Skin Neoplasms

Abstract

Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial. Elevated serum vitamin D levels above 60 nmol/L (24 ng/mL) have been linked to increased basal cell carcinoma risk. The study aims to investigate the association of tumor invasion parameters in basal cell carcinoma with vitamin D insufficiency levels. Material and Methods: Retrospective examination of basal cell carcinoma cases (2014-2024) with serum vitamin D levels 0.05). Conclusion: In basal cell carcinoma cases with vitamin D insufficiency, serum vitamin D level does not correlate with Clark level or Breslow thickness. Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

🔖

Cite This Article

Fındık, D. G., Türelik, Ö. (2025). Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels. Journal of Basic and Clinical Health Sciences, Volume: 9 Issue: 3. https://doi.org/10.30621/jbachs.1469888

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Mahamat-Saleh Y, Aune D, Schlesinger S. 25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose–response meta-analysis of prospective studies. Scientific Reports 2020;10(1):13151.
  2. Vornicescu C, Șenilă SC, Bejinariu NI, et al. Predictive factors for the recurrence of surgically excised basal cell carcinomas: A retrospective clinical and immunopathological pilot study. Experimental and therapeutic medicine. 2021;22(5):1-10.
  3. Amici J-M, Dousset L, Battistella M, et al., editors. Clinical factors predictive for histological aggressiveness of basal cell carcinoma: a prospective study of 2274 cases. Annales de Dermatologie et de Vénéréologie; 2021: Elsevier.
  4. Martin-Gorgojo A, Gilaberte Y, Nagore E. Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review. Nutrients 2021;13(12).
  5. Ringe JD, Kipshoven C. Vitamin D-insufficiency: An estimate of the situation in Germany. Dermatoendocrinol 2012;4(1):72-80.
  6. LeBlanc R. Staging 2023 (cited 2024 January 24th). Available from: https://www.pathologyoutlines.com/topic/skintumormelanocyticmelanomastaging.html.
  7. Niculet E, Craescu M, Rebegea L, et al. Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches. Experimental and Therapeutic Medicine. 2022;23(1):60.
  8. Eide MJ, Johnson DA, Jacobsen GR, et al. Vitamin D and nonmelanoma skin cancer in a health maintenance organization cohort. Archives of dermatology. 2011;147(12):1379-84.
  9. Liang G, Nan H, Qureshi AA, Han J. Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. PloS One 2012;7(4):e35211.
  10. Tang JY, Parimi N, Wu A, et al. Inverse association between serum 25 (OH) vitamin D levels and non-melanoma skin cancer in elderly men. Cancer Causes & Control. 2010;21:387-91.
  11. Abdelwahab R, Huang R, Potla S, et al. The relationship between vitamin D and basal cell carcinoma: a systematic review. Cureus 2022;14(9).
  12. Hakverdi S, Balci DD, Dogramaci CA, Toprak S, Yaldiz M. Retrospective analysis of basal cell carcinoma. Indian Journal of Dermatology, Venereology and Leprology 2011;77:251.
  13. Scrivener Y, Grosshans E, Cribier B. Variations of basal cell carcinomas according to gender, age, location and histopathological subtype. British Journal of Dermatology 2002;147(1):41-7.
  14. Ciążyńska M, Narbutt J, Woźniacka A, Lesiak A. Trends in basal cell carcinoma incidence rates: a 16-year retrospective study of a population in central Poland. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 2018;35(1):47-52.
  15. Jain C, Garg N, Singh S, Chattopadhyay S. Basal cell carcinoma-clinico-pathological study in Eastern India in correlation with different risk factors. Indian Journal of Pathology and Microbiology 2022;65(4):869-72.
  16. Ince B, Yildirim MEC, Dadaci M. Assessing the effect of vitamin D replacement on basal cell carcinoma occurrence and recurrence rates in patients with vitamin D deficiency. Hormones and Cancer 2019;10:145-9.