SavedAdd your journal

Journals / Journal of Basic and Clinical Health Sciences / 2026 / Volume: 10 Issue: 2

Effects of Exercise on miRNA Expression and Disease Management in Rheumatoid Arthritis: Exploring Treatment Efficacy and Severity

Zeynep Betül Özcan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE SAĞLIK BİLİMLERİ ENSTİTÜSÜ, FİZYOTERAPİ VE REHABİLİTASYON (DR))0000-0003-1788-7755
Mehmet Zahid Çıraci(Sakarya Eğitim ve Araştırma Hastanesi)0000-0002-4612-643X
Halime Hanım Pençe(Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, Temel Bilimler Bölümü)0000-0002-8346-1018
Fulya Senem Karaahmetoğlu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE SAĞLIK BİLİMLERİ ENSTİTÜSÜ, FİZYOTERAPİ VE REHABİLİTASYON (DR))0000-0002-4397-9322
Sibel Kuraş(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1230-7777
Bekir Erdoğan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU (İSTANBUL))0000-0001-9637-3837
Işıl Üstün(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL BAKIRKÖY DR. SADİ KONUK TRAINING RESEARCH CENTER)0000-0001-7305-6839
Meltem Vural(ACIBADEM ÜNİVERSİTESİ)0000-0003-4360-8318
Alev Kural(Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, Temel Bilimler Bölümü)0000-0003-1459-4316
Pages
—
Publication Date
2026-05-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further research is necessary to better understand these effects.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: This study aimed to investigate the effect of exercise on microRNA and mRNA expressions in patients with rheumatoid arthritis.
📊
Key Findings & Data:Material and Methods: 30 patients and 30 healthy controls aged 18-60 years who met the 2010 ACR / EULAR rheumatoid arthritis criteria were included in the study.
💡
Conclusion & Impact:However, further research is necessary to better understand these effects.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Rheumatoid arthritis · exercise · microRNA

Abstract

Purpose: This study aimed to investigate the effect of exercise on microRNA and mRNA expressions in patients with rheumatoid arthritis. Material and Methods: 30 patients and 30 healthy controls aged 18-60 years who met the 2010 ACR / EULAR rheumatoid arthritis criteria were included in the study. The study group followed an 8-week program of strengthening and stretching exercises twice a week, plus 30 minutes of mild-to-moderate walking once a week. Blood samples were taken at the start and end of the program for both groups. Pain, disease activity, general health, and quality of life were assessed. Gene expressions of miRNA-146a, miRNA-155, miRNA-16, and miRNA-145 were analyzed via real-time PCR in the blood samples. The control group only provided blood samples for gene expression analysis. Results: There was a significant improvement in pain, disease activity, general health, and quality of life scores before and after treatment in the rheumatoid arthritis group (p 0.05). MiRNA-146a expression did not significantly differ before and after treatment (p > 0.05), but both treatment groups showed significant differences compared to the control group (p 0.05). No significant differences were found in miRNA-155 and miRNA-16 expression levels across the groups (p > 0.05). Conclusion: Exercise therapy positively impacts pain, disease activity, quality of life, and general health in patients with rheumatoid arthritis. Additionally, exercise may influence certain miRNAs involved in the disease's pathogenesis. However, further research is necessary to better understand these effects.

Özet

Amaç: Bu çalışma, egzersizin romatoid artritli hastalarda mikroRNA ve mRNA ekspresyonları üzerindeki etkisini araştırmayı amaçladı. Gereç ve Yöntem: Çalışmaya 2010 ACR/EULAR romatoid artrit kriterlerini karşılayan, 18–60 yaş aralığında 30 hasta ve 30 sağlıklı kontrol dahil edildi. Çalışma grubuna haftada iki kez kuvvetlendirme ve germe egzersizlerinden oluşan 8 haftalık bir program ile haftada bir kez 30 dakikalık hafif-orta şiddette yürüyüş uygulandı. Her iki gruptan da programın başında ve sonunda kan örnekleri alındı. Ağrı, hastalık aktivitesi, genel sağlık ve yaşam kalitesi değerlendirildi. Kan örneklerinde miRNA-146a, miRNA-155, miRNA-16 ve miRNA-145’in gen ekspresyonları gerçek zamanlı PCR ile analiz edildi. Kontrol grubu yalnızca gen ekspresyon analizi için kan örneği verdi. Bulgular: Romatoid artrit grubunda tedavi öncesi ve sonrası ağrı, hastalık aktivitesi, genel sağlık ve yaşam kalitesi skorlarında anlamlı düzelme gözlendi (p 0,05). MiRNA-146a ekspresyonunda tedavi öncesi ve sonrası arasında anlamlı fark görülmedi (p > 0,05), ancak her iki tedavi grubu kontrol grubuna kıyasla anlamlı farklılık gösterdi (p 0,05). MiRNA-155 ve miRNA-16 ekspresyon seviyeleri açısından gruplar arasında anlamlı fark saptanmadı (p > 0,05). Sonuç: Egzersiz tedavisi, romatoid artritli hastalarda ağrı, hastalık aktivitesi, yaşam kalitesi ve genel sağlık üzerinde olumlu etkiler göstermektedir. Ayrıca egzersiz, hastalığın patogenezinde rol alan bazı miRNA’ları etkileyebilir. Bununla birlikte, bu etkilerin daha iyi anlaşılması için ileri çalışmalara ihtiyaç vardır.

🔖

Cite This Article

Özcan, Z. B., Çıraci, M. Z., Pençe, H. H., Karaahmetoğlu, F. S., Kuraş, S., Erdoğan, B., Üstün, I., Vural, M., Kural, A., *, Z. B. Ö. (2026). Effects of Exercise on miRNA Expression and Disease Management in Rheumatoid Arthritis: Exploring Treatment Efficacy and Severity. Journal of Basic and Clinical Health Sciences, Volume: 10 Issue: 2. https://doi.org/10.30621/jbachs.1788360

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (32)

  1. Guidelli GM, Barskova T, Giuseppina Brizi M, et al. One year in review: Novelties in the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2015;37(4):519–34.
  2. Zhang Y, Cai Y, Liang J, Xiao M, Zhang G, Jing Z, et al. The burden of rheumatoid arthritis: findings from the 2019 Global Burden of Disease study and forecasts for 2030 by Bayesian age–period–cohort analysis. J Clin Med. 2023;12(4):1291.
  3. Diane van der Woude AHM van der HM. Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2018;32(2):174–87.
  4. Alpízar-Rodríguez D, Finckh A. Environmental factors and hormones in the development of rheumatoid arthritis. Semin Immunopathol. 2017;39(4):461–8.
  5. Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017;31(1):3–18.
  6. Finckh A, Alpizar-Rodriguez D, Roux-Lombard P. Value of Biomarkers in the Prevention of Rheumatoid Arthritis. Clin Pharmacol Ther. 2017;102(4):585–7.
  7. Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6(1):15.
  8. Rausch Osthoff AK, Niedermann K, Braun J, Adams J, Brodin N, Dagfinrud H, et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77(9):1251–1260.
  9. Adeyemi T, Chukwuike VI, Oladimeji MA, Ahwinahwi US, Ayeni VA, Abdullahi AA, et al. Efficacy of pharmacological interventions and therapeutic exercises for rheumatoid arthritis: a systematic review and meta-analysis. Front Pharmacol. 2025;16:1686128.
  10. Evangelatos G, Fragoulis GE, Koulouri V, Lambrou GI. MicroRNAs in rheumatoid arthritis: from pathogenesis to clinical impact. Autoimmun Rev. 2019;18:102391.
  11. Balchin C, Tan AL, Wilson OJ, McKenna J, Stavropoulos-Kalinoglou A. The role of microRNAs in regulating inflammation and exercise-induced adaptations in rheumatoid arthritis. Rheumatol Adv Pract. 2023;7(1):rkac110.
  12. Peng X, Wang Q, Li W, et al. Comprehensive overview of microRNA function in rheumatoid arthritis. Bone Res. 2023;11:8.
  13. Van Craenenbroeck AH, Ledeganck KJ, Van Ackeren K, Jürgens A, Hoymans VY, Fransen E, et al. Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. Am J Physiol Heart Circ Physiol. 2015;309:H2008–H2016.
  14. Rajasekhar M, Olsson AM, Steel KJA, et al. MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis. J Autoimmun. 2017;79:53–62.
  15. Wells G, Becker JC, Teng J, et al. Validation of the 28- joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr. Ann Rheum Dis. 2009;68(6):954– 60.
  16. Fuchs HA, Pincus T. Reduced joint counts in controlled clinical trials in rheumatoid arthritis. Arthritis Rheum. 1994;37(4):463–4.
  17. Ware Jr. JE, Sherbourne CD. Ware JJ, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care 1992; 30:473-83. Med Care. 1992;30(6):473–83.
  18. Ferraz MB, Quaresma MR, Aquino LRL, Atra E, Tugwell P, Goldsmith CH. Reliability of pain scales in the assessment of literate and illiterate patients with rheumatoid arthritis. J Rheumatol. 1990;17(8):1022–4.
  19. Morishita S, Tsubaki A, Takabayashi T, Fu JB. Relationship between the rating of perceived exertion scale and the load intensity of resistance training. Strength Cond J. 2018;4(2):1.
  20. LucigenMasterPure™ Complete DNA and RNA Purification Kit, USA https://www.genesuz.com/urun/masterpure-complete-dna-and-rna-purification-kit/
  21. Bilberg A, Bjersing J, Börjesson M, Sivertsson J, Mannerkorpi K. High-intensity exercise improves multidimensional fatigue and health-related quality of life in rheumatoid arthritis: a randomized controlled study. Arthritis Res Ther. 2025;27.
  22. Athanasiou A, Papazachou O, Rovina N, Nanas S, Dimopoulos S, Kourek C. The effects of exercise training on functional capacity and quality of life in patients with rheumatoid arthritis: a systematic review. J Cardiovasc Dev Dis. 2024;11:161.
  23. Alapa N, Tafuto B, Mittal R. Impact of rehabilitation therapy on disease activity, function, and quality of life in rheumatoid arthritis: a systematic review. Cureus. 2025;17:e92627.
  24. Wen Z, Chai Y. Effectiveness of resistance exercises in the treatment of rheumatoid arthritis. Medicine (Baltimore). 2021;100:e25019.
  25. Fu X, Zhang L, Wang C, Yue J, Zhu H. The effect of exercise therapy on pain, fatigue, bone function and inflammatory biomarkers in individuals with rheumatoid arthritis and knee osteoarthritis: a meta-research review of randomized controlled trials. Front Physiol. 2025;16:1558214.
  26. Cerasola D, Argano C, Chiovaro V, Trivic T, Šćepanović T, Drid P, Corrao S. Physical exercise and occupational therapy at home to improve the quality of life in subjects affected by rheumatoid arthritis: a randomized controlled trial. Healthcare (Basel). 2023;1.
  27. Peng X, Wang Q, Li W, Ge G, Peng J, Xu Y, Yang H, Jia J. Comprehensive overview of microRNA function in rheumatoid arthritis. Bone Res. 2023;11(1):8.
  28. Chang C, Xu L, Zhang R, et al. MicroRNA-mediated epigenetic regulation of rheumatoid arthritis susceptibility and pathogenesis. Front Immunol. 2022;13:838884.
  29. Noor A, Ijaz MH, Anwar MM, Aziz S, Khan HM, Hassan M. Association of micro-RNA expression profiles with disease severity in rheumatoid arthritis patients. Insights J Health Rehabil. 2025;3(4):225-231.
  30. Hong BK, You S, Yoo SA, Park D, Hwang D, Cho CS, Kim WU. MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis. Exp Mol Med. 2017;49:e363.
  31. Martín-Márquez BT, Corona-Meraz FI, Aguilar-Vázquez A, et al. Association of miR-145-5p, miR-143-3p and miR-146a-5p with Simplified Disease Activity Index in rheumatoid arthritis. Open Access Rheumatol. 2025;17:251-264. doi:10.2147/OARRR.S561973.
  32. Silva FCD, Iop RDR, Andrade A, Costa VP, Gutierres Filho PJB, Silva RD. Effects of physical exercise on the expression of microRNAs: a systematic review. J Strength Cond Res. 2020;34(1):270-280.