Journals / Etlik Veteriner Mikrobiyoloji Dergisi / 1996 / Cilt: 8 - Sayı: 3

The experimental study on heparin, streptokinase, Vitamin-e and selenium for the prevention Of intraabdominal adhesions in rabbits

Tavşanlarda İntraabdominal Adezyonların Önlenmesinde Heparin, Streptokinaz, Vitamin-E ve Selenyum Kullanılması Üzerine Deneysel Çalışmalar

Pages
114–127
Publication Date
1996-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All these methods found to be meaninigful better than control gruoups.

📌 3 Key Takeaways

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Objective & Hypothesis:Adhesions are abdominal connections between peritoneal surfaces.
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Key Findings & Data:In this study, 40 unit/kg heparİn or 90.000 IU/kg streptokinase were applied intraabdominally 4 times with 12 hours intervals, vitamin-E 300 mg/kg or sodium selenit 0.5 mg/ kg IM 24 hours preoperativeiy, peroperatively and 24 hours postoperatively.
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Conclusion & Impact:All these methods found to be meaninigful better than control gruoups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tavşan · İntraabdominal Adezyonlar · Heparin

Abstract

Adhesions are abdominal connections between peritoneal surfaces. Postoperative peritoneal adhesions continue to be a serious surgical problem various methods have been tried with lirriited success to reduce the ineidence of peritoneal adhesions. These methods as the prevention of fibrin depositian in the postoperative period, the removal of the fibrinous exudate, which follows any surgical procedure by peritoneal surfaces and the inhibition of fibroblast proliferation using cytotoxic agents, antihistamines and steroids. In this study, 40 unit/kg heparİn or 90.000 IU/kg streptokinase were applied intraabdominally 4 times with 12 hours intervals, vitamin-E 300 mg/kg or sodium selenit 0.5 mg/ kg IM 24 hours preoperativeiy, peroperatively and 24 hours postoperatively. All these methods found to be meaninigful better than control gruoups.

Özet

Adezyonlar, periton yüzeyleri arasında oluşan anormal birleşmelerdir. Operasyon sonrası perİtonal yapışmalar, ciddi bir cerrahi problem olarak ortaya çıkar. Sınırlı başanya sahip değişik metotlar, perİtonal adezyonlann oluşumunu azaltmak için denenmiştir.Bu metotlar, postoperatif olarak şekillenen fibrinöz eksudatın proteolitik enzimlerle lavajı, steroidler, antihistaminikler ve sitotoksik ajanlar kullanılarak fibroblastik aktivasyonun inhibisyonu ve perİtonal yüzeylerin mekanik olarak ayrılması şeklinde sınıflandınlmıştır. Bu çalışmada, heparin'in 40 ünite/kg ve streptokinaz'ın 90.000 İU/kg intraperitonal olarak ı2 saat ara ile 4 kez, vitaminE'nin 300 mg/kg ve Sodyum selenit'in 0.5 mg/kg olarak operasyondan 24 saat önce, operasyon sonrası ve 24 saat sonra olmak üzere kas içi uygulanması ile kontrol grubuna oranla başarılı sonuçlar alınmıştır.

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Cite This Article

ALKAN, Z., BUMİN, A., ŞEKER, Y., GÜVENÇ, T. (1996). The experimental study on heparin, streptokinase, Vitamin-e and selenium for the prevention Of intraabdominal adhesions in rabbits. Etlik Veteriner Mikrobiyoloji Dergisi, Cilt: 8 - Sayı: 3, 114–127. https://ajindex.com/articles/120911

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References (11)

  1. Alan, A., De Cherney, M.D. (1984). Preventing postoperative pelvic adhesions with intraperitoneal treatment. The Journal of Reproductive Medicine, 29 (3): 157-161
  2. Anteplioğlu, H., Samsar, E., Akın, F. (1986).
  3. Veteriner Özel Şirurji. AÜ Basımevi, Ankara, 353-360
  4. Ascheri, R., Wriedt-Lübbe, 1., Rothe, M. (1983). Prophylaxe intraperitonealer Adhesionen mit einem fıbrinolyticum. Medwelt, 34 (13): 410- 415 Bateman, B.G., Nunley, W.C., Kitchin, J.D. (1982). Prevention ofpostoperative peritoneal adhesions with ibuprofen. Fertility and Sterility, 38 (1): 107- 108 Batzofın, J.H., Holmes, S.D., Gibbons, W.E., Butrau, V.C.(l985). Peritoneal fluid plasminogen activator activity in endometriosis and pelvic adhesive disease. Fertility and Sterility. 44 (2): 277-279
  5. Borten, M., Seibert, C.P., Taymor, M.L (1983). Recurrent anaphylactic reaction to intraperitoneal Dextran 75 used for prevention ofpostsurgical adhesions. Obstetrics and Gynecol. 61 (6): 755-756
  6. Demirel, H.(l990). Postoperatif periton adezyonlannın profilaksisinde Aprotinin, Dextran 70. Antiaksidan maddeler ve fibrinolitik ajaniann kullanımı ve sonuçlan. Uzamanlık Tezi, Ankara.
  7. Engle, W.A., Yoder, M.C., Baurley, J.L., Yu, pao-lo. (1988). Vitamin E decreases superoxide anion porduction buy polymorphnuclear leukocytes Pediauric Res. 23 (3): 245-248
  8. Erdener, A., Çetinkurşun, S., İlhan, H., İlman, İ. (1989). Postoperatifintraperitoneal yapışıklıklann önlenmesinde Evitaminin yeri. Ulusal Cerrahi Dergisi. 5 (3): 29-3 ı Fredericks, C.M., Kotry, I., Holtz, G., Askalani, AH, Serour, _G.I. (1986). Adhesion pervention in the rabbit with sodium carboxymethylcellulose solutions. Am.J.Obstet. Gynecol. 155 (3): 667-670
  9. Gervin, A.S., Puckett, C.L.-Silver, D. (1972). Serosal hypofibrinolysis. A cause of postoperative adhesions. Presented at the 13.th annual meeting of the society for surgery of the alimentary tract. San Fransisco, California. ! Hittner, H.M., Speer, M.E., Rudolph, A.J. (1984). Retrolental fibroplasia and Vitamin E in the preterm infant-comparison of oral versus intramuscular: Oraladminstration. Prediatrics, 73 (2): 238-249.
  10. James, D.C/0., Ellis, H., Hugh, T.B. (2965). The effect of streptokinase on experimental intraperitoneal adhesion formation. J.Path. Fact. 90:270- 286 Janic, J.S., Nagaraj, H.S., Groff, D.B (1982). Prevention ofpostoperative peritoneal adhesions. Arch. Surg. 117 (ll): 1321-1324
  11. Kagoma, P.,Burger, S.N.Seifter, E. (1985). The effect of vitamin E on experimentally ınduced peritoneal adhesion