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Journals / ENT Updates / 2026 / Cilt: 9 Sayı: 2

An Investigation of Genetic Polymorphism In The Rs35521 Serotonin Transporter Gene In Allergic Rhinitis

İsmail Salcan0000-0001-8034-1064
Sara Salcan0000-0001-5049-1838
Haktan Bağış Erdem0000-0002-4391-1387
Suphi Müderris0000-0001-6425-1421
Pages
107–114
Publication Date
2019-08-08
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The objective of our research was to investigate any connections between polymorphism in the serotonin transporter gene and allergic rhinitis.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Allergic rhinitis (AR) is one of the most frequently encountered allergic disorders and has a typical prevalence of between 18 and 40%.The factors which underlie allergic disorders may vary since they are linked to climate, geography, different social conditions and genetic makeup.
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Key Findings & Data:Objective: Allergic rhinitis (AR) is one of the most frequently encountered allergic disorders and has a typical prevalence of between 18 and 40%.The factors which underlie allergic disorders may vary since they are linked to climate, geography, different social conditions and genetic makeup.
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Conclusion & Impact:The objective of our research was to investigate any connections between polymorphism in the serotonin transporter gene and allergic rhinitis.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Allergic rhinitis · serotonin · serotonin transporter

Abstract

Objective: Allergic rhinitis (AR) is one of the most frequently encountered allergic disorders and has a typical prevalence of between 18 and 40%.The factors which underlie allergic disorders may vary since they are linked to climate, geography, different social conditions and genetic makeup. The objective of our research was to investigate any connections between polymorphism in the serotonin transporter gene and allergic rhinitis.

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Cite This Article

Salcan, İ., Salcan, S., Erdem, H. B., Müderris, S. (2019). An Investigation of Genetic Polymorphism In The Rs35521 Serotonin Transporter Gene In Allergic Rhinitis. ENT Updates, Cilt: 9 Sayı: 2, 107–114. https://doi.org/10.32448/entupdates.595445

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References (18)

  1. Öztürk Ö, Tokmak A, Güçlü E, Yıldızbaş Ş, Gültekin E. Skin Prick Test Results of Patients with Allergic Rhinitis in Düzce. [Article in Turkish] Düzce Tıp Fak Derg 2005;1:11-4.
  2. Holgate ST. Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol 1999;104:1139-46.
  3. Cogswell JJ, Mitchell EB, Alexander J. Parental smoking, breast feeding, and respiratory infection indevelopment of allergic diseases. Arch Dis Child 1987;62:338-44.
  4. Zeiger RS, Heller S, Mellon MH, et al. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: A randomized study. J Allergy Clin Immunol 1989;84:72-89.
  5. Floistrup H, Swartz J, Bergstrom A, et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006;117:59-66.
  6. Cingi C, Oğhan F, Ünlü H, Tekat A, Okuyucu Ş. Efficacy of montelukast and desloratadine combination in allergic rhinitis. [Article in Turkish] J Med Updates 2011;1:3-16.
  7. Catalano M. The challenges of psychopharmacogenetics. Am J Hum Genet 1999;65:606-10.
  8. Murphy DL, Lerner A, Rudnick G, Lesch KP. Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics. Mol Interv 2004;4:109-23.
  9. van Cauwenberge P, Bachert C, Passalacqua G, et al. Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy 2000;55:116-34.
  10. Rosenwasser LJ. Treatment of allergic rhinitis. Am J Med 2002;113:17-24.
  11. Nihlén U, Greiff L, Montnémery P, et al. Incidence and remission of selfreported allergic rhinitis symptoms in adults. Allergy 2006;61:1299-304.
  12. Bousquet J, Annesi-Maesano I, Carat F, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 2005;35:728-32.
  13. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31.
  14. Özkaya M, Doğu O, Sevim S, Çamdeviren H, Yalçınkaya D, Erdal ME. Serotonin transporter (SERT) gene polymorphism in Parkinson’s disease. [Article in Turkish] Turkish J Neurol 2004;10:201-5.
  15. Erdal ME, Herken H, Barlas Ö, Erdal N. Polymorphisms in the Serotonin Transporter Gene. [Article in Turkish] J Clin Psy 2000;3:192-6.
  16. Collier DA, Stöber G, Li T, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996;1:453-60.
  17. Karakülah K. Serotonin transporter gen polimorfizlerinin sigara bağımlılığı ve erişkin dikkat eksikliği hiperaktivite bozukluğu ile ilişkisi. Pamukkale Üniversitesi Tıp Fakültesi Ruh Sağliğı Ve Hastalıkları Anabilim Dalı. Uzmanlik Tezi Denizli 2013. http://acikerisim.pau.edu.tr/xmlui/ handle/11499/414.
  18. Farjadian S, Moghtaderi M, Fakhraei B, Nasiri M, Farjam M. Association between serotonin transporter gene polymorphisms and childhood asthma. J Asthma 2013;50:1031-5.