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Journals / Dicle Tıp Dergisi / 2014 / Cilt: 41 Sayı: 2

The effect of serum 25(OH) vitamin D on hemogram parameters

Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi

Gülfer Öztürk
Erdem Bulut
Sümeyya Akyol
Mine Yavuz Taşlıpınar
Zeynep Giniş
Fatma Uçar
Gönül Erden
Pages
332–336
Publication Date
2014-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin.
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Key Findings & Data:Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients.
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Conclusion & Impact:These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:D vitamini · WBC · RBC

Abstract

Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin. In general, vitamin D is known to be associated with rickets, but the studies show that vitamin D also acts on tissues and cells other than bone itself. In this study, we aimed to investigate if vitamin D has any effects on hemogram parameters or not. Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients. Vitamin D level and hemogram parameters [(red blood cell (RBC), hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW)] of patients were obtained. Patients were divided into 4 groups according to their levels of vitamin D: Group 1: < 10 ng/mL; Group 2: 10-19 ng/mL; Group 3: 20-29 ng/mL, and Group 4: 30-60 ng/mL. Results: There were no significant differences in RBC, Hb, WBC, PLT, MPV, and RDW between the groups (p>0.05). Also, there was no correlation between the hemogram parameters and vitamin D. Conclusion: According to the literature, there are a lot of studies that show the relationship between vitamin D and WBC, RBC, and PLT. However, contrary to the previous studies, we were unable to find any significant relationship between vitamin D and hemogram parameters. These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.

Özet

Amaç: D vitamini pleitropik hormon özellikleri olan yağda çözünen bir vitamindir. Genel anlamda rikets ile beraber anılır ancak yapılan araştırmalar D vitamininin kemik dışı dokularda da etkin olduğunu göstermektedir. Biz de bu çalışmada serum D vitamini düzeyinin hemogram parametrelerine etkisi olup olmadığını araştırmayı amaçladık. Yöntemler: Bu retrospektif çalışma, 243 kadın 59 erkek toplam 302 hastanın verileri değerlendirilerek gerçekleştirildi. Hastaların D vitamini düzeyi ve hemogram [eritrosit sayısı (RBC), hemoglobin (Hb), beyaz küre sayısı (WBC), trombosit sayısı (PLT), ortalama trombosit volümü (MPV) ve eritrosit dağılım genişliği (RDW)] parametreleri elde edildi. Hastalar D vitamini düzeylerine göre 4 gruba ayrıldı: Grup 1: < 10 ng/mL; Grup 2: 10-19 ng/mL; Grup 3: 20-29 ng/mL ve Grup 4: 30-60 ng/mL. Bulgular: Gruplar arası RBC, Hb, WBC, PLT, MPV ve RDW değerleri arasında anlamlı bir farklılık saptanmadı (p>0.05). Ayrıca, D vitamini ile hemogram parametreleri arasında herhangi bir korelasyon tespit edilmedi. Sonuçlar: Literatüre bakıldığında D vitamini ile WBC, RBC ve PLT arasında ilişki olduğunu gösteren çok sayıda yayın bulunmaktadır. Ancak, bizim çalışmamızda literatürün aksine D vitamini ile hemogram parametreleri arasında herhangi bir ilişki tespit edilemedi. Bu sonuçlar D vitamininin hematopoietik sistem üzerindeki etkilerinin deneysel ve klinik olarak daha iyi araştırılması gerektiği fikrini vermektedir.

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Cite This Article

Öztürk, G., Bulut, E., Akyol, S., Taşlıpınar, M. Y., Giniş, Z., Uçar, F., Erden, G. (2014). The effect of serum 25(OH) vitamin D on hemogram parameters. Dicle Tıp Dergisi, Cilt: 41 Sayı: 2, 332–336. https://doi.org/10.5798/diclemedj.0921.2014.02.0426

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References (31)

  1. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
  2. Bogunia-Kubik K, Middleton P, Norden J, et al. Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Int J Immunogenet 2008;35:207-213.
  3. Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1,25-dihy- droxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181-1183.
  4. Baeke F, Gysemans C, Korf H, et al. Vitamin D insufficien- cy: implications for the immune system. Pediatr Nephrol 2010;25:1597-1606.
  5. Yilmaz M, Yilmaz N. D vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. J Clin Exp Invest 2013; 4:411-415.
  6. Çidem M, Kara S, Sarı H, et al. Yaygın kas-iskelet ağrısı olan hastalarda D vitamini eksikliği prevalansı ve risk faktörleri. J Clin Exp Invest 2013; 4:488-491.
  7. Köse N. Fibromiyalji hastalarında kan vitamin D düzey- leri ve D vitamini tedavisinin etkinliği. Dicle Med J 2013; 40:583-588.
  8. Wallis DE, Penckofer S, Sizemore GW. The “sunshine defi- cit” and cardiovascular disease. Circulation 2008;118:1476- 1485.
  9. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovas- cular disease and vitamin D insufficiency into perspective. Br J Nutr 2005;94:483-492.
  10. Kıdır V. D vitamininin kardiyovasküler ve metabolik et- kileri. J Clin Exp Invest 2013; 4:398-404.
  11. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovas- cular risk factors and the serum levels of 25-hydroxyvita- min D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007;167:1159-1165.
  12. von Hurst PR, Stonehouse W, Coad J. Vitamin D supple- mentation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomized, placebo-controlled trial. Br J Nutr 2010;103:549-555.
  13. Bunce CM, Brown G, Hewison M. Vitamin D and hemato- poiesis. Trends Endocrinol Metab 1997;8:245-251.
  14. Grande A, Montanari M, Tagliafico E, et al. Physiological levels of 1alpha, 25 dihydroxyvitamin D3 induce the mono- cytic commitment of CD34+ hematopoietic progenitors. J Leukoc Biol 2002;71:641-651.
  15. Stach K, Kalsch AI, Nguyen XD, et al. 1alpha,25-dihy- droxyvitamin D3 attenuates platelet activation and the ex- pression of VCAM-1 and MT1-MMP in human endothelial cells. Cardiology. 2011;118:107-115.
  16. Muller K, Diamant M, Bendtzen K. Inhibition of produc- tion and function of interleukin-6 by 1,25-dihydroxyvita- min D3. Immunol Lett 1991;28:115-120.
  17. Cantorna MT, Woodward WD, Hayes CE. 1,25-dihy- droxyvitamin D3 is a positive regulator for the two anti-en- cephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol 1998;160:5314-5319.
  18. Icardi A, Paoletti E, De Nicola L, et al. Renal anaemia and EPO hyporesponsiveness associated with vitamin D defi- ciency: the potential role of inflammation. Nephrol Dial Transplant 2013;28:1672-1679.
  19. Luong QT, Koeffler HP. Vitamin D compounds in leukemia. J Steroid Biochem Mol Biol 2005;97:195-202.
  20. O’Kelly J, Hisatake J, Hisatake Y, et al. Normal myelopoi- esis but abnormal T lymphocyte responses in vitamin D re- ceptor knockout mice. J Clin Invest 2002;109:1091-1099.
  21. Yu S, Cantorna MT. Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice. J Im- munol 2011;186:1384-1390.
  22. Yu S, Zhao J, Cantorna MT. Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. J Immunol 2011;187:4907-4912.
  23. Kebapcilar AG, Kulaksizoglu M, Ipekci SH, et al. Relation- ship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency. Arch Gynecol Obstet 2013;288:207-212.
  24. Yildirim I, Hur E, Kokturk F. Inflammatory markers: C- reactive protein, erythrocyte sedimentation rate, and leuko- cyte count in vitamin D deficient patients with and without chronic kidney disease. Int J Endocrinol 2013;2013:802165.
  25. Bockow B, Kaplan TB. Refractory immune thrombocyto- penia successfully treated with high-dose vitamin D sup- plementation and hydroxychloroquine: two case reports. J Med Case Rep 2013;7:91.
  26. Norman AW. Minireview: vitamin D receptor: new as- signments for an already busy receptor. Endocrinology 2006;147:5542-5548.
  27. Patel NM, Gutierrez OM, Andress DL, et al. Vitamin D de- ficiency and anemia in early chronic kidney disease. Kid- ney Int 2010;77:715-720.
  28. Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta 2013;421:177-180.
  29. Goicoechea M, Vazquez MI, Ruiz MA, et al. Intravenous calcitriol improves anaemia and reduces the need for eryth- ropoietin in haemodialysis patients. Nephron 1998;78:23- 27.
  30. Carvalho C, Isakova T, Collerone G, et al. Hepcidin and disordered mineral metabolism in chronic kidney disease. Clin Nephrol 2011;76:90-98.
  31. Toxqui L, Perez-Granados AM, Blanco-Rojo R, et al. Ef- fects of an iron or iron and vitamin D-fortified flavored skim milk on iron metabolism: a randomized controlled double-blind trial in iron-deficient women. J Am Coll Nutr 2013;32:312-320.