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Journals / Dicle Tıp Dergisi / 2026 / Cilt: 46 Sayı: 1

Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio

Zafer Pekkolay0000-0002-5323-2257
Mazhar Müslüm Tuna0000-0001-5975-7786
Mehmet Güven0000-0002-0752-8815
Şadiye Altun Tuzcu0000-0003-3326-5358
İbrahim Kaplan0000-0003-2813-1064
Zeki Akkuş0000-0002-6161-3666
Alpaslan Kemal Tuzcu0000-0002-1814-9773
Pages
119–124
Publication Date
2019-03-03
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ROC analysis(control-macroprolactin) for serum/urine prolactin ratio (Sensitivity 84.6 specificity 93.7 cut off >549,5 AUC=0.83) p<0.01 Conclusion: Urinary prolactin level and serum/urine prolactin ratio may be used in diagnosis of macroprolactinemia.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the urine prolactin and serum/urine prolactin ratio for accuracy diagnosis of macroprolactinemia.
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Key Findings & Data:Results: A total of 41 patients were included in the study.
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Conclusion & Impact:ROC analysis(control-macroprolactin) for serum/urine prolactin ratio (Sensitivity 84.6 specificity 93.7 cut off >549,5 AUC=0.83) p<0.01 Conclusion: Urinary prolactin level and serum/urine prolactin ratio may be used in diagnosis of macroprolactinemia.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:macroprolactinemia · urine prolactin

Özet

Objective: The aim of this study was to investigate the urine prolactin and serum/urine prolactin ratio for accuracy diagnosis of macroprolactinemia. Methods: In the retrospective cross-sectional analysis, prolactin levels (high or normal) in the reproductive period of men and women were included in the study. Polyethylene glycol (PEG) precipitation method was used for the detection of macroprolactinemia. Then, patients were divided into three groups as macroprolactinemia, prolactinoma and healthy control group. In patients, prolactin values in spot urine with simultaneous serum prolactin values were calculated. The non-parametric Kruskal-Wallis test was used to compare the groups. The receiver-operating characteristic (ROC) curve was determined to evaluate the predictive power of serum/urine prolactin ratio. Results: A total of 41 patients were included in the study. Female/male:36 (87.8%)/ 5 (12.2%). Urinary prolactin median(minimum-maximum) values were macroprolactinemia, prolactinoma and control group, respectively; 0.06(0.05-0.10), 0.11(0.02-0.95), 0.08(0.05-0.25) ng/ml. Serum/urine ratio median (minium-maximum) values were macroprolactinemia, prolactinoma, and control group, respectively; 633(51-1032), 990(104-9635), 395.5(138-953). When the groups were compared, the patients with prolactinoma had higher urinary prolactin levels(p <0.01). Serum/urine prolactin ratio was found to be the highest in prolactinoma patients and the lowest in the control group and a significant difference was observed in groups (p <0.01). ROC analysis(control-macroprolactin) for serum/urine prolactin ratio (Sensitivity 84.6 specificity 93.7 cut off >549,5 AUC=0.83) p<0.01 Conclusion: Urinary prolactin level and serum/urine prolactin ratio may be used in diagnosis of macroprolactinemia.

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Cite This Article

Pekkolay, Z., Tuna, M. M., Güven, M., Tuzcu, Ş. A., Kaplan, İ., Akkuş, Z., Tuzcu, A. K. (2019). Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi, Cilt: 46 Sayı: 1, 119–124. https://doi.org/10.5798/dicletip.534848

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