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Journals / Dicle Tıp Dergisi / 2026 / Cilt: 46 Sayı: 2

The effect of oral micronized progesterone on first trimester screening test markers and neonatal outcome

İlknur Col Madendag0000-0001-6700-2236
Yusuf Madendag0000-0002-7622-2991
Mehmet Ak0000-0003-3384-0586
Erdem Sahin0000-0001-9492-6223
Mefkure Eraslan Sahin0000-0001-6484-9132
Pages
195–200
Publication Date
2019-06-11
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Our results suggest that in clinical practice, 1) it seems that using OMP cannot affect on NT, CRL and birth weight. 2) OMP cannot adversely affect on production of PAPP-A and β-hCG in vivo. 3) NT, serum PAPP-A and β-hCG levels and MoM values, which are markers of the first trimester screening test, do not change by using OMP.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It was aimed to investigate whether or not nuchal translucency(NT) thickness, maternal serum free beta-human chorionic gonadotropin(β-hCG) and pregnancy-associated plasma protein-A(PAPP-A) levels may affected by the use of oral micronized progesterone(OMP) in first trimester pregnancies.
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Key Findings & Data:Method: This study was performed retrospectively including 1192 pregnant women, between January 2015 and August 2017.
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Conclusion & Impact:Conclusions: Our results suggest that in clinical practice, 1) it seems that using OMP cannot affect on NT, CRL and birth weight. 2) OMP cannot adversely affect on production of PAPP-A and β-hCG in vivo. 3) NT, serum PAPP-A and β-hCG levels and MoM values, which are markers of the first trimester screening test, do not change by using OMP.
🔬Design:Araştırma Makalesi
📍Scope:2015 Verileri
⚙️Variables:Nuchal translucency measurement · prenatal diagnosis · progesterone

Özet

Objective: It was aimed to investigate whether or not nuchal translucency(NT) thickness, maternal serum free beta-human chorionic gonadotropin(β-hCG) and pregnancy-associated plasma protein-A(PAPP-A) levels may affected by the use of oral micronized progesterone(OMP) in first trimester pregnancies. Also we aimed to evaluate pregnancy outcome in pregnant women using OMP. Method: This study was performed retrospectively including 1192 pregnant women, between January 2015 and August 2017. Body mass index(BMI), maternal and gestational age, levels of maternal serum PAPP-A and free β-hCG, NT measurement and the crown–rump length(CRL), fetal sex, fetal birth weight, Apgar score 5thminute<7 and admission to neonatal intensive care unit(NICU) were evaluated. Results: Maternal characteristics, ultrasound and biochemical parameters, fetal characteristics and neonatal outcome were evaluated. There was no statistically significant difference for maternal age, BMI, gestational age, PAPP-A, β-hCG, CRL, NT thickness, fetal sex, fetal birth weight, Apgar score 5th minute <7 and the number of admission to NICU during the first 28 days. Conclusions: Our results suggest that in clinical practice, 1) it seems that using OMP cannot affect on NT, CRL and birth weight. 2) OMP cannot adversely affect on production of PAPP-A and β-hCG in vivo. 3) NT, serum PAPP-A and β-hCG levels and MoM values, which are markers of the first trimester screening test, do not change by using OMP. Therefore using OMP cannot affect reliability of the first trimester screening test in pregnancy with threatened abortion. 4) OMP does not look like adversely affect on poor neonatal outcome.

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Cite This Article

Madendag, İ. C., Madendag, Y., Ak, M., Sahin, E., Sahin, M. E. (2019). The effect of oral micronized progesterone on first trimester screening test markers and neonatal outcome. Dicle Tıp Dergisi, Cilt: 46 Sayı: 2, 195–200. https://doi.org/10.5798/dicletip.539903

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