Journals / Dicle Tıp Dergisi / 2026 / Cilt: 46 Sayı: 3

Over, Böbrek ve Beyinde İskemi / Reperfüzyon Sonrası Redoks Dengesi ve Tribulus Terrestris L.’nin Etkileri

Pages
525–534
Publication Date
2019-09-16
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bu çalışma over, böbrek ve beyinde reperfüzyon hasarında Tribulus ekstresinin redoks dengesi üzerine etkilerini araştırmayı hedeflemiştir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Amaç: Oksidatif stres prooksidan ve antioksidan sistemler arasında oksidasyon lehine bir dengesizlik olarak tanımlanır ve iskemi / reperfüzyon hasarı gibi çeşitli patolojilerden sorumlu tutulmaktadır.
📊
Key Findings & Data:Tribulusterrestris L. (demir dikeni) güçlü antioksidan etki sergileyen flavonoidler ve saponinler açısından zengin bir tıbbi bitkidir.
💡
Conclusion & Impact:Bu çalışma over, böbrek ve beyinde reperfüzyon hasarında Tribulus ekstresinin redoks dengesi üzerine etkilerini araştırmayı hedeflemiştir.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Tribulus · demir dikeni

Özet

Amaç: Oksidatif stres prooksidan ve antioksidan sistemler arasında oksidasyon lehine bir dengesizlik olarak tanımlanır ve iskemi / reperfüzyon hasarı gibi çeşitli patolojilerden sorumlu tutulmaktadır. Eksojen antioksidanlar redoks dengesinin geri kazanılmasında faydalıdırlar. Tribulusterrestris L. (demir dikeni) güçlü antioksidan etki sergileyen flavonoidler ve saponinler açısından zengin bir tıbbi bitkidir. Bu çalışma over, böbrek ve beyinde reperfüzyon hasarında Tribulus ekstresinin redoks dengesi üzerine etkilerini araştırmayı hedeflemiştir.

🔖

Cite This Article

Demir, E. A. (2019). Over, Böbrek ve Beyinde İskemi / Reperfüzyon Sonrası Redoks Dengesi ve Tribulus Terrestris L.’nin Etkileri. Dicle Tıp Dergisi, Cilt: 46 Sayı: 3, 525–534. https://doi.org/10.5798/dicletip.620570

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (31)

  1. Czerska M, Mikołajewska K, Zieliński M, et all. Today’s oxidative stress markers. Med Pr. 2015; 66: 393–405.
  2. Rajendran P, Nandakumar N, Rengarajan T, et all. Antioxidants and human diseases. Clin Chim Acta. 2014; 436: 332–47.
  3. Cuzzocrea S, Riley DP, Caputi AP, et all. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001; 53: 135–59.
  4. Zweier J, Talukder M. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res. 2006; 70: 181–90.
  5. Zhang Y-J, Gan R-Y, Li S, et all. Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules. 2015; 20: 21138–56.
  6. Sun A, Xu X, Lin J, et all. Neuroprotection by Saponins. Phyther Res. 2015; 29: 187–200.
  7. Singh B, Singh JP, Singh N, et all. Saponins in pulses and their health promoting activities: A review. Food Chem. 2017; 233: 540–9.
  8. Adaikan P, Gauthaman K, Prasad R. History of herbal medicines with an insight on the pharmacological properties of Tribulus terrestris. Aging Male. 2001; 4: 163–9.
  9. Chhatre S, Nesari T, Somani G, et all. Phytopharmacological overview of Tribulus terrestris. Pharmacogn Rev. 2014; 8: 45–51.
  10. Mashchenko NE, Gyulemetova R, Kintya PK, et all. A sulfated glycoside from the preparation “tribestan.” Chem Nat Compd. 1990; 26: 552–5.
  11. Kostova I, Dinchev D. Saponins in Tribulus terrestris-chemistry and bioactivity. Phytochem Rev. 2005; 4: 111–37.
  12. Zhu W, Du Y, Meng H, et all. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris. Chem Cent J. 2017; 11: 60.
  13. Park YJ, Cho Y-R, Oh JS, et all. Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Mol Med Rep. 2017; 16: 5303–11.
  14. Polat R. Ethnobotanical study on medicinal plants in Bingöl (City center) (Turkey). J Herb Med. 2018; 100211.
  15. Yang S. The divine farmer’s materia medica: a translation of the Shen Nong Ben Cao Jing, 5th edn. Boulder, CO: Blue Poppy Press, 2007: 1-43.
  16. Amin A, Lotfy M, Shafiullah M, et all. The Protective Effect of Tribulus terrestris in Diabetes. Ann N Y Acad Sci. 2006; 1084: 391–401.
  17. Zhang J-D, Xu Z, Cao Y-B, et all. Antifungal activities and action mechanisms of compounds from Tribulus terrestris L. J Ethnopharmacol. 2006; 103: 76–84.
  18. Usman H, Abdulrahman F, Ladan A. Phytochemical and Antimicrobial Evaluation of Tribulus terrestris L. (Zygophyllaceae) Growing in Nigeria. Res J Biol Sci. 2007; 2: 244–7.
  19. Phillips OA, Mathew KT, Oriowo MA. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J Ethnopharmacol. 2006; 104: 351–5.
  20. Heidari MR, Mehrabani M, Pardakhty A, et all. The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. Ann N Y Acad Sci. 2007; 1095: 418–27.
  21. Wu M-Y, Yiang G-T, Liao W-T, et all. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018; 46: 1650–67.
  22. Kalogeris T, Baines CP, Krenz M, et all. Ischemia/Reperfusion. Compr Physiol. 2016; 7: 113–70.
  23. Kalogeris T, Baines CP, Krenz M, et all. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012; 298: 229–317.
  24. Comhair SAA, Erzurum SC. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol Cell Mol Physiol. 2002; 283: L246–55.
  25. Abuelo A, Hernández J, Benedito JL, et all. Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period. Animal. 2013; 7: 1374–8.
  26. Zheleva-Dimitrova D, Obreshkova D, Nedialkov P. Antioxidant activity of Tribulus terrestris—a natural product in infertility therapy. Int J Pharm Pharm Sci. 2012; 4: 508–11.
  27. Zhang S, Li H, Yang S. Tribulosin protects rat hearts from ischemia/reperfusion injury. Acta Pharmacol Sin. 2010; 31: 671–8.
  28. Najafi H, Firouzifar MR, Omid S, et all. Protective Effects of Tribulus Terrestris L Extract Against Acute Kidney Injury Induced By Reperfusion Injury in Rats. Iran J Kidney Dis. 2014; 8: 292–8.
  29. Melekoglu R, Ciftci O, Eraslan S, et all. The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries. Biomed Res Int. 2018; 2018: 5421308.
  30. Nayki C, Nayki U, Keskin Cimen F, et all. The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. Gynecol Endocrinol. 2018; 34: 809–14.
  31. Yang S. The divine farmer’s materia medica: a translation of the Shen Nong Ben Cao Jing, 5th edn. Boulder, CO: Blue Poppy Press, 2007: 1-43.