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Journals / Dicle Tıp Dergisi / 2026 / Cilt: 46 Sayı: 3

Thymoquinone induces apoptosis via targeting the Bax/BAD and Bcl-2 pathway in breast cancer cells

İbrahim Halil Yıldırım0000-0001-5518-5004
Ali Ahmed Azzawri0000-0001-5311-8887
Tuğçe Duran0000-0002-7353-4527
Pages
411–417
Publication Date
2019-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this study was to determine the effect of Thymoquinone on apoptosis in both tumor and non-tumor cells. 

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Nigella sativa, commonly known as the black seed, has been used since ancient times in folk medicine, and its various therapeutic benefits have been mentioned in some ancient medical sources and confirmed by modern science.
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Key Findings & Data:Thymoquinone is the major compound and essential active ingredient of Nigella sativa seed oil.
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Conclusion & Impact:The aim of this study was to determine the effect of Thymoquinone on apoptosis in both tumor and non-tumor cells. 
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Thymoquinone · breast cancer

Özet

Objective: Nigella sativa, commonly known as the black seed, has been used since ancient times in folk medicine, and its various therapeutic benefits have been mentioned in some ancient medical sources and confirmed by modern science. Thymoquinone is the major compound and essential active ingredient of Nigella sativa seed oil. Thymoquinone has been reported to have high biological activity and broad therapeutic potential through several mechanisms that affect cells including anti-oxidant, anti-inflammatory, and anti-tumor properties. Although it has been widely reported that Thymoquinone inhibits cell growth and proliferation and stimulates apoptosis in various types of cancer cells, the mechanisms and signaling pathways are not fully understood. The aim of this study was to determine the effect of Thymoquinone on apoptosis in both tumor and non-tumor cells. 

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Cite This Article

Yıldırım, İ. H., Azzawri, A. A., Duran, T. (2019). Thymoquinone induces apoptosis via targeting the Bax/BAD and Bcl-2 pathway in breast cancer cells. Dicle Tıp Dergisi, Cilt: 46 Sayı: 3, 411–417. https://doi.org/10.5798/dicletip.620329

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