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Journals / Dicle Tıp Dergisi / 2026 / Cilt: 47 Sayı: 1

Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Reyhan Gündüz(DICLE UNIVERSITY)
Mete Gurol Ugur(GAZIANTEP UNIVERSITY, GAZİANTEP HEALTH ACADEMY)
Neslihan Bayramoğlu Tepe(GAZIANTEP UNIVERSITY, GAZİANTEP HEALTH ACADEMY)
Hüseyin Çağlayan Özcan(GAZIANTEP UNIVERSITY, GAZİANTEP HEALTH ACADEMY)
Özcan Balat(GAZIANTEP UNIVERSITY, GAZİANTEP HEALTH ACADEMY)
Sevgi Sari Demir(CUKUROVA UNIVERSITY, ADANA HEALTH ACADEMY)
Seyithan Taysi(GAZIANTEP UNIVERSITY, GAZİANTEP HEALTH ACADEMY)
Pages
74–81
Publication Date
2020-03-17
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, this role must be further delineated in large-scaled studies for early diagnosis and management of this condition.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in patients with first trimester miscarriage.
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Key Findings & Data:Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and 35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdG levels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDA levels were also measured in both groups.
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Conclusion & Impact:However, this role must be further delineated in large-scaled studies for early diagnosis and management of this condition.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Oxidative Stress · malondialdehyde · 8-hydroxy-2-deoxyguanosine

Özet

Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in patients with first trimester miscarriage. Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and 35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdG levels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDA levels were also measured in both groups. Results: There wasn’t difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteine values, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels were significantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestational week and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week were detected in the patient group. Conclusion: 8-OHdG and MDA could play a role in the etiopathogenesis of first-trimester miscarriage. However, this role must be further delineated in large-scaled studies for early diagnosis and management of this condition.

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Cite This Article

Gündüz, R., Ugur, M. G., Tepe, N. B., Özcan, H. Ç., Balat, Ö., Demir, S. S., Taysi, S. (2020). Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Tıp Dergisi, Cilt: 47 Sayı: 1, 74–81. https://doi.org/10.5798/dicletip.706022

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