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Journals / Dicle Tıp Dergisi / 2026 / Cilt: 53 Sayı: 1

Efficacy of mycophenolate mofetil treatment in patients with immune thrombocytopenia who have received at least one series of treatment: a single-center study

En az bir seri tedavi almış immun trombositopeni tanılı hastalarda mikofenolat mofetil tedavisinin etkinliği: tek merkez çalışması

Abdullah Karakuş(DICLE UNIVERSITY)
Vehbi Demircan(Dicle University)
Orhan Ayyıldız(Dicle University)
Pages
103–107
Publication Date
2026-03-10
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Mycophenolate mofetil may be considered a potential treatment option for patients with chronic ITP who are refractory to first- and second-line therapies.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The objective of this study was to evaluate the efficacy of mycophenolate mofetil (MMF) as a second- or third-line treatment for chronic immune thrombocytopenia (ITP).
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Key Findings & Data:Methods: A cohort of 13 patients with chronic ITP, who had previously been treated with eltrombopag, corticosteroids, or both, without achieving an effective response, was administered mycophenolate mofetil at a daily dosage of 1000 mg.
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Conclusion & Impact:Conclusions: Mycophenolate mofetil may be considered a potential treatment option for patients with chronic ITP who are refractory to first- and second-line therapies.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Mikofenolat mofetil · Trombositopeni · Dirençli.

Abstract

Background: The objective of this study was to evaluate the efficacy of mycophenolate mofetil (MMF) as a second- or third-line treatment for chronic immune thrombocytopenia (ITP). Methods: A cohort of 13 patients with chronic ITP, who had previously been treated with eltrombopag, corticosteroids, or both, without achieving an effective response, was administered mycophenolate mofetil at a daily dosage of 1000 mg. Platelet counts were monitored at the fourth and twelfth weeks of treatment. Results: In our study, 13 patients were included, consisting of 4 females (30.8%) and 9 males (69.2%). At the 12-week mark following the initiation of MMF therapy, three out of 13 patients achieved a complete response, three out of 13 patients achieved a partial response, and seven patients showed no response. (Fig.1). At the time of transitioning to Mycophenolate Mofetil (MMF), all patients had a platelet count below 30 × 10^9/L. Approximately 40% of patients experienced an increase in platelet counts to levels above 30 × 10^9/L. Conclusions: Mycophenolate mofetil may be considered a potential treatment option for patients with chronic ITP who are refractory to first- and second-line therapies.

Özet

Amaç: Bu çalışmanın amacı, kronik immün trombositopeni (İTP) tedavisinde ikinci veya üçüncü basamak tedavi olarak mikofenolat mofetilin (MMF) etkinliğini değerlendirmektir. Yöntemler: Daha önce eltrombopag, kortikosteroidler veya her ikisiyle tedavi edilmiş ve etkili bir yanıt alınamamış kronik İTP'li 13 hastadan oluşan bir kohorta, günlük 1000 mg mikofenolat mofetil uygulandı. Trombosit sayıları, tedavinin dördüncü ve on ikinci haftalarında izlendi. Bulgular: Çalışmamıza 4 kadın (%30,8) ve 9 erkek (%69,2) olmak üzere toplam 13 hasta dahil edildi. MMF tedavisinin başlamasından sonraki 12. haftada, 13 hastanın 3'ünde tam yanıt, 13 hastanın 3'ünde yanıt ve 7 hastada yanıt alınamamıştır. Mikofenolat Mofetil'e (MMF) geçiş sırasında tüm hastaların trombosit sayısı 30 × 10^9/L'nin altındaydı. Hastaların yaklaşık %40'ında trombosit sayılarında 30 × 10^9/L'nin üzerine çıkan bir artış görüldü. Sonuç: Mikofenolat mofetil, birinci ve ikinci basamak tedavilere dirençli kronik İTP'li hastalar için potansiyel bir tedavi seçeneği olarak düşünülebilir.

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Cite This Article

Karakuş, A., Demircan, V., Ayyıldız, O. (2026). Efficacy of mycophenolate mofetil treatment in patients with immune thrombocytopenia who have received at least one series of treatment: a single-center study. Dicle Tıp Dergisi, Cilt: 53 Sayı: 1, 103–107. https://doi.org/10.5798/dicletip.1906458

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References (15)

  1. Stasi R. How to approach thrombocytopenia.Hematology. 2012(1); 191–7.
  2. Terrell DR, Neunert CE, Cooper N, et al. ImmuneThrombocytopenia (ITP): Current Limitations inPatient Management. Medicina. 2020; 56(12):667.
  3. González-López T. J, Newland A, Provan D. CurrentConcepts in the Diagnosis and Management of AdultPrimary Immune Thrombocytopenia: Our PersonalView. Medicina. 2023; 59(4): 815.
  4. Liu X, Hou Y, Hou M. How we treat primaryimmune thrombocytopenia in adults. J. Hematol.Oncol.J Hematol Oncol. 2023; 16 (4): 1-20.
  5. Martínez-Carballeira D, Bernardo Á, Caro A, Soto I, Gutiérrez L. Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective. Hematol Rep. 2024 Apr 3;16(2):204-19.
  6. Al-Samkari H, Kuter, DJ. Immunethrombocytopenia in adults: modern approaches todiagnosis and treatment, Semin. Thromb. Hemost.2020;46(3): 275–88.
  7. Cohen YC, Djulbegovic B, Shamai-Lubovitz O,Mozes B. The Bleeding Risk and Natural History ofIdiopathic Thrombocytopenic Purpura in Patientswith Persistent Low Platelet Counts. Arch. Intern.Med. 2000;160(3): 1630–8.
  8. Allison AC, Eugui EM. Purine metabolism andimmunosuppressive effects of mycophenolatemofetil (MMF). Clin. Transplant. 1996; 10: 77–84.
  9. Hou M, Peng J, Shi Y, et al. Mycophenolate mofetil(MMF) for the treatment of steroid-resistantidiopathic thrombocytopenic purpura. Eur JHaematol. 2003;70(6):353-7.
  10. K. Kojouri, S.K. Vesely, D.R. Terrell, J.N. GeorgeSplenectomy for adult patients with idiopathicthrombocytopenic purpura: a systematic review toassess long-term platelet count responses,prediction of response, and surgical complicationsBlood, 104 (2004), pp. 2623-34.
  11. Audia S., Mahevas M., Samson M., Godeau B.,Bonnotte B. Pathogenesis of immunethrombocytopenia. Autoimmun. Rev. 2017; 16:620–32.
  12. Bradbury CA, Pell J, Hill Q, et al. Mycophenolatemofetil for first-line treatment of immunethrombocytopenia. New England J Med.2021;385(10):885–95.
  13. Abdelwahab OA, Mechi A, Gahlan S, et al. Efficacyand safety of mycophenolate mofetil in patients withimmune thrombocytopenic purpura: a systematicreview and meta-analysis. Clin. Rheumatol. 2024;43(2): 621–32.
  14. Zhang W. Ji L, Cao X, Chen Y, et al. Mycophenolatemofetil as a treatment for refractory idiopathicthrombocytopenic purpura. Acta Pharmacol. Sin.2005; 26(5): 598–602.
  15. Taylor A, Neave L, Solanki S, et al. Mycophenolate mofetil therapy for severe immune thrombocytopenia. Br J Haematol. 2015;171(4):625-30.