Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2011 / Cilt: 37 Sayı: 3

The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer

Lokal İleri ve Metastatik Mide Kanserli Hastalarda Tedavi Öncesi AFP, CEA ve CA 19-9 Serum Seviyeleri ile Klinikopatolojik Faktörlerin Arasındaki İlişki

Pages
139–143
Publication Date
2011-09-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In summary, in cancer patients, the use of tumor markers for the decision of treatment might indicate the existence of any organ metastasis which could not be clinically or radiologically revealed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pre-treatment serum levels of AFP, CEA and CA 19-9 were retrospectively investigated in 70 patients with locally advanced and metastatic gastric cancer.
📊
Key Findings & Data:The positivity rates for these markers were 55.7%, 40% and 32.9%, respectively.
💡
Conclusion & Impact:In summary, in cancer patients, the use of tumor markers for the decision of treatment might indicate the existence of any organ metastasis which could not be clinically or radiologically revealed.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Mide kanseri. Serum tümör belirteçleri. AFP. CEA. CA 19-9. · Gastric cancer. Tumor markers. AFP. CEA. CA 19-9

Abstract

Pre-treatment serum levels of AFP, CEA and CA 19-9 were retrospectively investigated in 70 patients with locally advanced and metastatic gastric cancer. The positivity rates for these markers were 55.7%, 40% and 32.9%, respectively. Multiple logistic regression analysis for positive levels of tumor markers indicates that AFP positivity is significantly related to the presence of hepatic metastasis and resectability rates (p=0.041), CEA positivity is related to advance stage (p=0.011), tumor size (p=0.004), presence of hepatic metastasis (p=0.001), the frequency of serosal invasion (p=0.004) and resectability rates (p=0.011). Finally, CA 19-9 positivity is related to advance stage (p=0.006), tumor size (p=0.002), the frequency of serosal invasion (p=0.002), the frequency of peritoneal metastasis (p=0.005) and ascites (p=0.005). In summary, in cancer patients, the use of tumor markers for the decision of treatment might indicate the existence of any organ metastasis which could not be clinically or radiologically revealed.

Özet

Lokal ileri ve metastatik mide kanserli 70 hastanın tedavi öncesi AFP, CEA ve CA 19-9 serum seviyeleri retrospektif olarak araştırıldı. Bu markerlar için pozitiflik oranı sırasıyla %55.7, %40 ve %32.9 bulundu. Tümör belirteçlerinin pozitif seviyeleri için univaryet analizleri, AFP pozitifliğinin karaciğer metastaz varlığı (p=0.033) ve rezektabilite oranı ile anlamlı ilişkisinin olduğunu (p=0.041), CEA pozitifliğinin ileri tümör evresi (p=0.011), tümör boyutu (p=0.004), karaciğer metastaz varlığı (p=0.001), serozal invazyon sıklığı (p=0.004) ve rezektabilite (p=0.011) ile anlamlı ilişkisinin olduğunu ve son olarak CA 19.9 pozitifliğinin ileri tümör evresi (p=0.006), tümör boyutu (p=0.002), serozal invazyon sıklığı (p=0.002), periton metastaz sıklığı (p=0.005) ve asit gelişimi (p=0.005) ile anlamlı ilişkisinin olduğunu gösterdi. Sonuç olarak, kanser hastalarında tedavi kararı verilirken tümör markeri kullanımı, klinik ve radyolojik olarak tespit edilemeyen uzak organ metas-taz varlığını gösterebilir.

🔖

Cite This Article

Bayrak, M., Ölmez, Ö. F., Kurt, E., Çubukcu, E., Avcı, N., Çubukcu, S., Söker, P., Manavoğlu, O. (2011). The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 37 Sayı: 3, 139–143. https://ajindex.com/articles/1182865

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...