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Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2025 / Cilt: 51 Sayı: 1

The Side Effects of Levetiracetam Monotherapy in Pediatric Epilepsy Patients

Pediatrik Epilepsi Hastalarında Levetirasetam Monoterapisinin Yan Etkileri

Serap Bilge(Department of Pediatric Neurology, Ministry of Health, Children Hospital of Diyarbakır, Diyarbakır, Türkiye.)0000-0002-4265-3363
Nevzat Başkaya(Department of Pediatric Allergy and Immunology, Ministry of Health, Children Hospital of Diyarbakır, Diyarbakır, Türkiye.)0000-0002-5587-0041
Pages
125–131
Publication Date
2025-05-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Additionally, lower B12 levels may contribute to the onset of certain side effects.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Levetiracetam is a broad-spectrum second-generation anti-seizure drug.
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Key Findings & Data:The study included pediatric epilepsy patients aged 1-17 who were treated with levetiracetam monotherapy.
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Conclusion & Impact:Additionally, lower B12 levels may contribute to the onset of certain side effects.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Levetiracetam · Side-effects · Agitation

Abstract

Levetiracetam is a broad-spectrum second-generation anti-seizure drug. Several side effects can be observed during treatment. In this study, we retrospectively evaluated the side effects of levetiracetam monotherapy in the pediatric epilepsy population and investigated potential indicators that could predict these side effects in the pediatric epilepsy population. The study included pediatric epilepsy patients aged 1-17 who were treated with levetiracetam monotherapy. Data collected included age, gender, body weight, blood pressure, duration of levetiracetam use, dosage, seizure semiology, epilepsy type, EEG and MRI findings, hematological and biochemical laboratory results, and observed side effects. Eighty-five patients were included in the study, with 25 (29%) experiencing side effects. Treatment was discontinued in 11 patients due to these effects. The most common side effects were agitation (9%), headache (6%), and fatigue (5%). No significant relationship was found between side effects and gender, body weight, seizure type, levetiracetam dose, treatment duration, EEG results, or MRI findings. However, vitamin B12 levels were lower in patients with side effects compared to those without. Additionally, side effects were more frequently observed in older age groups. Levetiracetam treatment has been linked to both physical and behavioral side effects, which were more commonly observed in older age groups. The most frequently reported side effects were agitation, headache, and fatigue. Additionally, lower B12 levels may contribute to the onset of certain side effects.

Özet

Levetiracetam geniş spektrumlu ikinci nesil anti-nöbet ilacıdır. Tedavi sırasında çeşitli yan etkiler görülebilir. Bu çalışmada, pediatrik epilepsi popülasyonunda levetiracetam monoterapisinin yan etkilerini retrospektif olarak değerlendirdik. Çalışmaya levetiracetam monoterapisi ile tedavi edilen 1-17 yaş arası epilepsili hastalar dahil edildi. Yaş, cinsiyet, vücut ağırlığı, kan basıncı, levetiracetam kullanım süresi, doz, semiyoloji, epilepsi tipi, EEG ve MRI bulguları, hemogram ve biyokimyasal laboratuvar bulguları ve gözlenen yan etkiler kaydedildi. Çalışmaya 85 hasta dahil edildi. Yirmi beş (%29) hastada yan etki görüldü. Yan etkiler nedeniyle 11 hastada tedavi kesildi. En sık görülen üç yan etki ajitasyon (8 hasta, %9), baş ağrısı (5 hasta, %5) ve yorgunluktu (3 hasta, %4). Yan etkiler ile cinsiyet, vücut ağırlığı, nöbet tipi, levetirasetam dozu, süresi, EEG ve MRI bulguları arasında ilişki bulunmamıştır. Yan etki görülen grupta B12 vitamini düzeyleri daha düşük bulunmuştur. Yan etkiler daha yaşlı yaş gruplarında daha sık görülmüştür. Levetirasetam tedavisinde fiziksel-davranışsal yan etkiler gözlenmiştir. Yan etki görülen yaş grubu daha yüksekti. En sık görülen üç yan etki ajitasyon, baş ağrısı ve yorgunluk olmuştur. Düşük B12 düzeyleri bazı yan etkilerin başlamasında rol oynayabilir.

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Cite This Article

Bilge, S., Başkaya, N., *, S. B. (2025). The Side Effects of Levetiracetam Monotherapy in Pediatric Epilepsy Patients. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 51 Sayı: 1, 125–131. https://doi.org/10.32708/uutfd.1621691

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