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Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2025 / Cilt: 52

Investigation of the Relationship Between Serum Subfatin Levels and Clinical Outcomes in Patients with Ischemic Wake-Up Stroke in the Emergency Department

Acil Serviste İskemik Uyanma İnmesi Hastalarında Serum Subfatin Düzeyleri ve Klinik Sonuçlar Arasındaki İlişkinin Araştırılması

Ayşen Zeybek(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0001-5208-1656
Melih Yüksel(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0002-0793-3693
Mehmet Oğuzhan Ay(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0003-1061-5327
Yeşim İşler(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0002-6389-5361
Halil Kaya(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0003-2005-6100
Zülfi Engindeniz(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0003-1874-5097
Ömer Furkan Demir(Department of Cardiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0002-0230-8442
Demet Yıldız(Department of Neurology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0003-0807-8980
Kağan Huysal(Department of Clinical Biochemistry, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0000-0003-3142-5944
Serhat Çakır(Department of Emergency Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye.)0009-0004-9735-2762
Pages
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Publication Date
2026-03-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Larger studies are needed to validate these findings.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study aimed to investigate the association between admission serum subfatin levels and 28- and 90-day mortality and functional outcomes (Modified Rankin Scale, mRS) in patients diagnosed with ischemic wake-up stroke in the emergency department.
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Key Findings & Data:Between April 2022 and March 2023, 66 patients presenting with wake-up stroke and 71 healthy controls were prospectively evaluated.
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Conclusion & Impact:Larger studies are needed to validate these findings.
🔬Design:Araştırma Makalesi
📍Scope:2022 Verileri
⚙️Variables:subfatin · uyanma inmesi · acil servis

Abstract

This study aimed to investigate the association between admission serum subfatin levels and 28- and 90-day mortality and functional outcomes (Modified Rankin Scale, mRS) in patients diagnosed with ischemic wake-up stroke in the emergency department. Between April 2022 and March 2023, 66 patients presenting with wake-up stroke and 71 healthy controls were prospectively evaluated. Serum subfatin levels were measured by ELISA in all participants. Mortality and mRS scores at 28 and 90 days were recorded for the patient group. Serum subfatin levels were significantly lower in the patient group compared to controls (median: 1.44 ng/dL vs. 1.65 ng/dL; p<0.001). However, there was no significant association between subfatin levels and 28- or 90-day mortality or 90-day mRS scores (p>0.05). Subfatin levels showed significant differences in patients with anterior cerebral artery and superior cerebellar artery involvement (p<0.05). Serum subfatin levels are lower in patients with ischemic wake-up stroke than in healthy controls. However, no significant relationship was found between subfatin levels and short- or medium-term mortality or functional outcomes. Larger studies are needed to validate these findings.

Özet

Bu çalışmanın amacı, acil serviste iskemik uyanma inmesi tanısı alan hastalarda başvuru anında ölçülen serum subfatin düzeylerinin, 28 ve 90. gün mortalite ve fonksiyonel sonuçlar (Modified Rankin Scale, mRS) ile ilişkisini araştırmaktır. Nisan 2022-Mart 2023 tarihleri arasında acil servise uyanma inmesi ile başvuran 66 hasta ve 71 sağlıklı kontrol prospektif olarak değerlendirildi. Tüm katılımcılardan alınan serum örneklerinde subfatin düzeyleri ELISA yöntemiyle ölçüldü. Hastaların 28 ve 90. gün mortalite ve mRS skorları kaydedildi. Hasta grubunda serum subfatin düzeyleri anlamlı olarak daha düşük bulundu (medyan: 1,44 ng/dL; kontrol: 1,65 ng/dL; p<0,001). Ancak, subfatin düzeyleri ile 28 ve 90. gün mortalite veya 90. gün mRS skorları arasında anlamlı bir ilişki saptanmadı (p>0,05). Subfatin düzeyleri, anterior serebral arter ve superior serebellar arter tutulumu olan hastalarda anlamlı farklılık gösterdi (p<0,05). Serum subfatin düzeyleri, iskemik uyanma inmesi hastalarında sağlıklı kontrollere göre daha düşüktür. Ancak, subfatin düzeyleri ile kısa ve orta vadeli mortalite veya fonksiyonel sonuçlar arasında anlamlı bir ilişki bulunmamıştır. Bulguların doğrulanması için daha geniş ölçekli çalışmalara ihtiyaç vardır.

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Cite This Article

Zeybek, A., Yüksel, M., Ay, M. O., İşler, Y., Kaya, H., Engindeniz, Z., Demir, Ö. F., Yıldız, D., Huysal, K., Çakır, S., *, Z. E. (2026). Investigation of the Relationship Between Serum Subfatin Levels and Clinical Outcomes in Patients with Ischemic Wake-Up Stroke in the Emergency Department. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 52. https://doi.org/10.32708/uutfd.1802044

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