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Journals / Kocatepe Veteriner Dergisi / 2024 / Cilt: 17 Sayı: 4

Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats

Sıçanlarda Glifosat İzopropilamin ile Oluşturulan Testiküler Hasara Karşı Klorojenik Asidin Koruyucu Etkisi

Ruhi Türkmen(Afyon Kocatepe Üniversitesi Veteriner Fakültesi)0000-0003-4726-3900
Yavuz Osman Birdane(AFYON KOCATEPE UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0003-0754-7909
Orkun Atik(AFYON KOCATEPE UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0003-2411-7492
Hasan Hüseyin Demirel(AFYON KOCATEPE UNIVERSITY, BAYAT VOCATIONAL SCHOOL)0000-0002-4795-2266
Türkan Türkmen(AFYON KOCATEPE UNIVERSITY, INSTITUTE OF HEALTH SCIENCES)0000-0003-0736-8927
Özay Güleş(AYDIN ADNAN MENDERES UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0001-6170-1706
Pages
334–340
Publication Date
2025-01-03
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid (CGA) on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine (GLF-ISO) in testicular tissues.
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Key Findings & Data:A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats.
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Conclusion & Impact:The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Glyphosate İzopropilamin · Klorojenik asit · Oksidatif stres

Abstract

The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid (CGA) on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine (GLF-ISO) in testicular tissues. A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats. For pretreatment, rats were given CGA at doses of 12.5, 25 and 50 mg/kg (po) and GLF-ISO at 787.85 mg/kg (po) for 7 weeks. GLF-ISO significantly increased malondialdehyde levels while decreasing SOD and CAT activities and GSH levels in testicular tissues. On the contrary, these parameters were improved in CGA-treated groups. Furthermore, CGA ameliorated the histopathological and histological changes in testicular tissues induced by GLF-ISO in a dose-dependent manner. The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.

Özet

Bu subkronik toksisite çalışmasının amacı, testis dokularında Glifosat izopropilamin (GLF-ISO) tarafından indüklenen histopatolojik-histolojik değişiklikler ve oksidatif stres üzerinde klorojenik asidin (CGA) profilaktik etkisini belirlemektir. Toplam 42 erkek Wistar sıçan, her biri 7 sıçan içeren altı eşit gruba ayrılmıştır. Ön muamele için sıçanlara 7 hafta boyunca 12.5, 25 ve 50 mg/kg (po) dozlarında CGA ve 787.85 mg/kg (po) dozunda GLF-ISO verilmiştir. GLF-ISO testis dokularında malondialdehit seviyelerini önemli ölçüde artırırken SOD ve CAT aktivitelerini ve GSH seviyelerini azaltmıştır. Aksine, bu parametreler CGA ile tedavi edilen gruplarda iyileşmiştir. Ayrıca, CGA, GLF-ISO tarafından indüklenen testis dokularındaki histopatolojik ve histolojik değişiklikleri doza bağlı bir şekilde iyileştirmiştir. Sonuçlar, GLF-ISO'nun neden olduğu testis hasarının CGA ile potansiyel olarak önlenebileceğini veya yönetilebileceğini göstermektedir.

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Cite This Article

Türkmen, R., Birdane, Y. O., Atik, O., Demirel, H. H., Türkmen, T., Güleş, Ö. (2025). Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats. Kocatepe Veteriner Dergisi, Cilt: 17 Sayı: 4, 334–340. https://doi.org/10.30607/kvj.1520615

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