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Journals / Etlik Veteriner Mikrobiyoloji Dergisi / 2026 / Cilt: 28 Sayı: 1

Melatonin, Etkileri ve Kullanım Alanları

Ayris Salt(ONDOKUZ MAYIS ÜNİVERSİTESİ)
Metin Çenesiz(ONDOKUZ MAYIS ÜNİVERSİTESİ)0000-0003-2494-1959
Sena Çenesiz(ONDOKUZ MAYIS ÜNİVERSİTESİ)
Pages
7–12
Publication Date
2017-06-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bu derlemede melatoninin biyokimyasal özellikleri ile kullanım alanları anlatılmaktadır.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px} p.p2 {margin: 0.0px 0.0px 4.0px 19.0px; text-align: justify; line-height: 9.1px; font: 9.0px 'Times New Roman'} span.s1 {font: 12.0px 'Times New Roman'}   Melatonin günlük ve mevsimsel değişiklik gösterebilen pineal bezden salgılanan ve suprakiazmatik nukleus tarafından endojen ritmi düzenleyen bir hormondur.
📊
Key Findings & Data:Bağışıklık sistemi üzerine de olumlu etkileri bulunmaktadır.
💡
Conclusion & Impact:Bu derlemede melatoninin biyokimyasal özellikleri ile kullanım alanları anlatılmaktadır.
🔬Design:Experimental Field Trial
📍Scope:Comprehensive Sample
⚙️Variables:Antikanserojenik etki · Antioksidan etki · Melatonin

Özet

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px} p.p2 {margin: 0.0px 0.0px 4.0px 19.0px; text-align: justify; line-height: 9.1px; font: 9.0px 'Times New Roman'} span.s1 {font: 12.0px 'Times New Roman'}   Melatonin günlük ve mevsimsel değişiklik gösterebilen pineal bezden salgılanan ve suprakiazmatik nukleus tarafından endojen ritmi düzenleyen bir hormondur. Günümüzde tıp ve veteriner hekimlikte ekzojen kullanım alanlarının genişlemesi bu hormonun önemini arttırmıştır. Hücresel kompartmanlara kolayca geçebilen bu hormon güçlü bir antioksidan özellik göstermekle beraber, sirkadyen ritmi düzenleyerek vücutta homeostazisi sağlar. Bağışıklık sistemi üzerine de olumlu etkileri bulunmaktadır. Bazı hayvan türlerinde de üreme siklusunu başlatıcı ya da inhibe edici etki gösterir. Yapılan çalışmalarla melatoninin antikanserojenik etkinliği ortaya koyulmuştur. Bu derlemede melatoninin biyokimyasal özellikleri ile kullanım alanları anlatılmaktadır.

🔖

Cite This Article

Salt, A., Çenesiz, M., Çenesiz, S. (2017). Melatonin, Etkileri ve Kullanım Alanları. Etlik Veteriner Mikrobiyoloji Dergisi, Cilt: 28 Sayı: 1, 7–12. https://doi.org/10.35864/evmd.530085

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References (98)

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  31. Provinciali M, Di Stefano G, Bulian D, Tibaldi A, and Fabris N, (1996). Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice. Mech Ageing Dev. 90(1), 1–19
  32. Reiter RJ, (1991a). Neuroendocrine effects of light. Int J Biometeorol. 35, 169-175
  33. Reiter RJ, (1991b). Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocrine Reviews. 12(2), 151–80
  34. Reiter RJ, Tan DX, Osuna C, Gitto E, (2000). Actions of melatonin in the reduction of oxidative stress. J Biomed Sci. 7, 444-458
  35. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM, (2010). Melatonin: Pharmacological Aspects and Clinical Trends. Int J Neurosci. 120(9), 583-590
  36. Satué K, Gardón JC, (2013). Review of the Estrous Cycle and the Neuroendocrine Mechanisms in the Mare. J Steroids Horm Sci. 4(2),115
  37. Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 23 Suppl 1, 79-83
  38. Simonneaux V, Ribelayga C, (2003). Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters. Pharmacol Rev. 55(2), 325-395
  39. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM, (1995). Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 27(2), 355–357
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  41. Topal T, Korkmaz A, (2009). Melatonin ve kanserle ilişkisi. Genel Tıp Derg. 19(3), 137-143
  42. Touitou Y, Le Hoang P, Claustrat B, Attye T, Auzeby A, Brun J, Bogdan A, Touitou C, (1986). Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. Neurosci Lett. 70(1), 170–174
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  44. Waterhouse J, Reilly T, Atkinson G, Edwards B, (2007). Jet lag: trends and coping strategies. Lancet. 369, 1117–1129
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  46. Witt-Enderby PA, Bennett J, Jarzynka MJ, Firestine S, Melan MA, (2003). Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198
  47. Wurtman RJ, Axelrod J, Chu EW, (1963). Melatonin, a pineal substance: Effect on the rat ovary. Science. 141, 277- 278
  48. Yazıcı C, Köse K, (2004). Melatonin: karanlığın antioksidan gücü. E.Ü.Journal of Health Sciences. 13(2), 56-65
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  51. Altun A, Yaprak M, Vardar A, Aktoz M, Özbay G, (2001). Decreased nocturnal melatonin secretion in coronary artery disease (abstr). J Coronary Artery Dis. 4: 108
  52. Bendz LM, Scates AC, (2010). Melatonin Treatment for Insomnia in Pediatric patients with Attention-Deficit/ Hyperactivity Disorder. Ann Pharmacother. 44(1), 185-91
  53. Beyer CE, Steketee JD, Saphier D, (1998). Antioxidant properties of melatonin--an emerging mystery. Biochem Pharmacol. 56(10), 1265-1272
  54. Canoğlu E, Sarıbay K, (2012). Koyun ve keçilerde doğum ve jinekoloji. Semacan A, Kaymaz M, Fındık M, Rişvanlı A, Köker A. eds. Çiftlik hayvanlarında doğum ve jinekoloji. Malatya, Medipres Maatbacılık, Malatya. p.521-649
  55. Claustrat B, Brun J, Chazot G, (2005). The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 9: 11–24
  56. Claustrat B, Geoffriau M, Brun J, Chazot G, (1995). Melatonin in humans: a biochemical marker of the circadian clock and an endogenous synchronizer. Neurophysiol Clin. 25(6):351-359
  57. Crowell-Davis SL, (2007). Sexual behavior of mares. Horm Behav. 52, 12–17
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  59. Dubocovich ML, Markowska M, (2005). Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 27, 101-110
  60. Fiorina P, Lattuada G, Silvestrini C, Ponari O, Dall’Aglio P, (1999) Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients. Scand J Immunol. 50(2), 228–231
  61. Ghosh D, Paul S, Naaz S, Bhowmik D, Dutta M, Ghosh AK, Firdaus SD, Chattopadhyay A, Reiter RJ, Bandyopadhyay D, (2016). Melatonin protects against lead acetate induced oxidative stress-mediated changes in morphology and metabolic status in rat red blood cells: a flow cytometric and biochemical analysis. J Pharm Res.10(6),381-402
  62. Hardeland R, Reiter RJ, Poeggeler B, Tan D-X, (1993). The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev. 17, 347-357
  63. K-Laflamme A, Wu L, de Champlain J, (1998). Impaired basal sympathetic tone and alpha 1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am J Hypertens. 11, 219-29
  64. Koçak A, Çolak A, (1996). Melatonin ve Santral Sinir Sistemi. Turgut Özal Tıp Merkezi Dergisi. 3(3), 237-244
  65. Kutzler MA, (2015). Alternative methods for feline fertility control: Use of melatonin to suppress reproduction. J Feline Med Surg. 17, 753–757 17. Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Gorevski MP, and Dubocovich ML, (2016). MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Annu. Rev. Pharmacol. Toxicol. 56, 361-383
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  68. Nagy P, Guillaume D, Daels P, (2000). Seasonality in mares. Anim Reprod Sci. 60-61, 245-262
  69. Nosjean O, Ferro M, Coge F, Beauverger P, Henlin JM, Lefoulon F, Fauchere JL, Delagrange P, Canet E, Boutin JA, (2000). Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 275 (40), 31311–31317
  70. Okur Gümüşova S, Memiş YS, (2014). Bazı Viral Enfeksiyonlarda Melatoninin Etkileri. Atatürk Üniversitesi Vet. Bil. Derg. 9(1), 50-54
  71. Özgüner F, Özcankaya R, Delibaş N, Koyu A, Çalışkan S, (1995). Melatonin ve klinik önemi. SDÜ tıp fakültesi Dergisi. 2(4), 1-6
  72. Öztürk L, Darıyerli N, (2000). Melatonin ve Uyku Fizyolojisi. Türkiye Tıp Derg. 7(2), 104-109
  73. Özyurtlu N, Bademkıran S, (2010). Koyunlarda Östrus Senkronizasyonu ve Östrusu Uyarma Yöntemleri. Dicle Üniv Vet Fak Derg. 1(1), 17-22
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  79. Acute effects. Theriogenology. 49(6), 1113-1123
  80. Provinciali M, Di Stefano G, Bulian D, Tibaldi A, and Fabris N, (1996). Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice. Mech Ageing Dev. 90(1), 1–19
  81. Reiter RJ, (1991a). Neuroendocrine effects of light. Int J Biometeorol. 35, 169-175
  82. Reiter RJ, (1991b). Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocrine Reviews. 12(2), 151–80
  83. Reiter RJ, Tan DX, Osuna C, Gitto E, (2000). Actions of melatonin in the reduction of oxidative stress. J Biomed Sci. 7, 444-458
  84. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM, (2010). Melatonin: Pharmacological Aspects and Clinical Trends. Int J Neurosci. 120(9), 583-590
  85. Satué K, Gardón JC, (2013). Review of the Estrous Cycle and the Neuroendocrine Mechanisms in the Mare. J Steroids Horm Sci. 4(2),115
  86. Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 23 Suppl 1, 79-83
  87. Simonneaux V, Ribelayga C, (2003). Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters. Pharmacol Rev. 55(2), 325-395
  88. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM, (1995). Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 27(2), 355–357
  89. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP, (2008). Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs. Travel Med Infect Dis. 6(1-2), 17-28
  90. Topal T, Korkmaz A, (2009). Melatonin ve kanserle ilişkisi. Genel Tıp Derg. 19(3), 137-143
  91. Touitou Y, Le Hoang P, Claustrat B, Attye T, Auzeby A, Brun J, Bogdan A, Touitou C, (1986). Decreased nocturnal plasma melatonin peak in patients with a functional alteration of the retina in relation with uveitis. Neurosci Lett. 70(1), 170–174
  92. Uyar A, Alan M, (2008). Koyunlarda Erken Anöstrüs Döneminde Melatonin Uygulamalarının Ovulasyon ve Gebelik Üzerine Etkisi. YYÜ vet fak derg. 19(1), 47-54
  93. Waterhouse J, Reilly T, Atkinson G, Edwards B, (2007). Jet lag: trends and coping strategies. Lancet. 369, 1117–1129
  94. Williams GL, Thorson JF, Prezotto LD, Velez IC, Cardoso RC, Amstalden M, (2012). Reproductive seasonality in the mare: neuroendocrine basis and pharmacologic control. Domest Anim Endocrinol. 43(2), 103-115
  95. Witt-Enderby PA, Bennett J, Jarzynka MJ, Firestine S, Melan MA, (2003). Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci. 72, 2183–2198
  96. Wurtman RJ, Axelrod J, Chu EW, (1963). Melatonin, a pineal substance: Effect on the rat ovary. Science. 141, 277- 278
  97. Yazıcı C, Köse K, (2004). Melatonin: karanlığın antioksidan gücü. E.Ü.Journal of Health Sciences. 13(2), 56-65
  98. Yonei Y, Hattori A, Tsutsui K, Okawa M, Ishizuka B, (2010). Effects of Melatonin: Basics Studies and Clinical Applications. Anti-Aging Medicine. 7(7), 85-89.