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Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

Mustafa NİSARİ
Recep ERÖZ
Pages
1076–1081
Publication Date
2020-08-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer Caco-2 cell .
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Key Findings & Data:Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses 25uµ, 50uµ, and 75uµ .
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Conclusion & Impact:Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:AgNOR · capsaicin · human colon adenocarcinoma

Abstract

Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer Caco-2 cell . Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses 25uµ, 50uµ, and 75uµ . Mean AgNOR number and total AgNOR area/nuclear area TAA/NA were calculated. Results: A significant differences were detected between control and capsaicin 50uµ P = 0.001 , between control and capsaicin 75uµ P = 0.000 , between capsaicin 25uµ and capsaicin 50uµ P = 0.001 and between capsaicin 25uµ and capsaicin 75uµ P = 0.000 for TAA/NA. Also, there were significant differences between control and capsaicin 50uµ P = 0.001 , between control and capsaicin 75uµ P = 0.000 , between capsaicin 25uµ and capsaicin 50uµ P = 0.000 and between capsaicin 25uµ and capsaicin 75uµ P = 0.000 for mean AgNOR number. Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.

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Cite This Article

NİSARİ, M., ERÖZ, R. (2020). Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 1076–1081. https://ajindex.com/articles/113200

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